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Antiepileptic drugs and breastfeeding.
Ital J Pediatr 2013; 39:50IJ

Abstract

INTRODUCTION

This review provides a synopsis for clinicians on the use of antiepileptic drugs (AEDs) in the breastfeeding mother.

METHODS

For each AED, we collected all retrievable data from Hale's "Medications and Mother Milk" (2012), from the LactMed database (2013) of the National Library of Medicine, and from a MedLine Search of relevant studies in the past 10 years.

RESULTS

Older AEDs, such as carbamazepine, valproic acid, phenytoin, phenobarbital, primidone are considered to have a good level of safety during lactation, due to the long term clinical experience and the consequent amount of available data from the scientific literature. On the contrary, fewer data are available on the use of new AEDs. Therefore, gabapentin, lamotrigine, oxcarbazepine, vigabatrin, tiagabine, pregabalin, leviracetam and topiramate are compatible with breastfeeding with a less documented safety profile. Ethosuximide, zonisamide and the continue use of clonazepam and diazepam are contraindicated during breastfeeding.

CONCLUSIONS

Although the current available advice on the use of AEDs during breastfeeding, given by different accredited sources, present some contradictions, most AEDs can be considered safe according to our review.

Authors+Show Affiliations

Division of Neonatology, Institute for Maternal and Child Health - IRCCS "Burlo Garofolo", Via dell'Istria 65/1, Trieste 34100, Italy. lorenza.matarazzo@gmail.com.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23985170

Citation

Davanzo, Riccardo, et al. "Antiepileptic Drugs and Breastfeeding." Italian Journal of Pediatrics, vol. 39, 2013, p. 50.
Davanzo R, Dal Bo S, Bua J, et al. Antiepileptic drugs and breastfeeding. Ital J Pediatr. 2013;39:50.
Davanzo, R., Dal Bo, S., Bua, J., Copertino, M., Zanelli, E., & Matarazzo, L. (2013). Antiepileptic drugs and breastfeeding. Italian Journal of Pediatrics, 39, p. 50. doi:10.1186/1824-7288-39-50.
Davanzo R, et al. Antiepileptic Drugs and Breastfeeding. Ital J Pediatr. 2013 Aug 28;39:50. PubMed PMID: 23985170.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antiepileptic drugs and breastfeeding. AU - Davanzo,Riccardo, AU - Dal Bo,Sara, AU - Bua,Jenny, AU - Copertino,Marco, AU - Zanelli,Elisa, AU - Matarazzo,Lorenza, Y1 - 2013/08/28/ PY - 2013/04/23/received PY - 2013/08/10/accepted PY - 2013/8/30/entrez PY - 2013/8/30/pubmed PY - 2014/7/24/medline SP - 50 EP - 50 JF - Italian journal of pediatrics JO - Ital J Pediatr VL - 39 N2 - INTRODUCTION: This review provides a synopsis for clinicians on the use of antiepileptic drugs (AEDs) in the breastfeeding mother. METHODS: For each AED, we collected all retrievable data from Hale's "Medications and Mother Milk" (2012), from the LactMed database (2013) of the National Library of Medicine, and from a MedLine Search of relevant studies in the past 10 years. RESULTS: Older AEDs, such as carbamazepine, valproic acid, phenytoin, phenobarbital, primidone are considered to have a good level of safety during lactation, due to the long term clinical experience and the consequent amount of available data from the scientific literature. On the contrary, fewer data are available on the use of new AEDs. Therefore, gabapentin, lamotrigine, oxcarbazepine, vigabatrin, tiagabine, pregabalin, leviracetam and topiramate are compatible with breastfeeding with a less documented safety profile. Ethosuximide, zonisamide and the continue use of clonazepam and diazepam are contraindicated during breastfeeding. CONCLUSIONS: Although the current available advice on the use of AEDs during breastfeeding, given by different accredited sources, present some contradictions, most AEDs can be considered safe according to our review. SN - 1824-7288 UR - https://www.unboundmedicine.com/medline/citation/23985170/Antiepileptic_drugs_and_breastfeeding_ L2 - https://ijponline.biomedcentral.com/articles/10.1186/1824-7288-39-50 DB - PRIME DP - Unbound Medicine ER -