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Familial resemblance for serum metabolite concentrations.
Twin Res Hum Genet 2013; 16(5):948-61TR

Abstract

Metabolomics is the comprehensive study of metabolites, which are the substrates, intermediate, and end products of cellular metabolism. The heritability of the concentrations of circulating metabolites bears relevance for evaluating their suitability as biomarkers for disease. We report aspects of familial resemblance for the concentrations in human serum of more than 100 metabolites, measured using a targeted metabolomics platform. Age- and sex-corrected monozygotic twin correlations, midparent-offspring regression coefficients, and spouse correlations in subjects from two independent cohorts (Netherlands Twin Register and Leiden Longevity Study) were estimated for each metabolite. In the Netherlands Twin Register subjects, who were largely fasting, we found significant monozygotic twin correlations for 121 out of 123 metabolites. Heritability was confirmed by midparent-offspring regression. For most detected metabolites, the correlations between spouses were considerably lower than those between twins, indicating a contribution of genetic effects to familial resemblance. Remarkably high heritability was observed for free carnitine (monozygotic twin correlation 0.66), for the amino acids serine (monozygotic twin correlation 0.77) and threonine (monozygotic twin correlation 0.64), and for phosphatidylcholine acyl-alkyl C40:3 (monozygotic twin correlation 0.77). For octenoylcarnitine, a consistent point estimate of approximately 0.50 was found for the spouse correlations in the two cohorts as well as for the monozygotic twin correlation, suggesting that familiality for this metabolite is explained by shared environment. We conclude that for the majority of metabolites targeted by the used metabolomics platform, the familial resemblance of serum concentrations is largely genetic. Our results contribute to the knowledge of the heritability of fasting serum metabolite concentrations, which is relevant for biomarker research.

Authors+Show Affiliations

Department of Biological Psychology, Faculty of Psychology and Education, VU University Amsterdam, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23985338

Citation

Draisma, Harmen H M., et al. "Familial Resemblance for Serum Metabolite Concentrations." Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies, vol. 16, no. 5, 2013, pp. 948-61.
Draisma HH, Beekman M, Pool R, et al. Familial resemblance for serum metabolite concentrations. Twin Res Hum Genet. 2013;16(5):948-61.
Draisma, H. H., Beekman, M., Pool, R., van Ommen, G. J., Adamski, J., Prehn, C., ... Boomsma, D. I. (2013). Familial resemblance for serum metabolite concentrations. Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies, 16(5), pp. 948-61. doi:10.1017/thg.2013.59.
Draisma HH, et al. Familial Resemblance for Serum Metabolite Concentrations. Twin Res Hum Genet. 2013;16(5):948-61. PubMed PMID: 23985338.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Familial resemblance for serum metabolite concentrations. AU - Draisma,Harmen H M, AU - Beekman,Marian, AU - Pool,René, AU - van Ommen,Gert-Jan B, AU - Adamski,Jerzy, AU - Prehn,Cornelia, AU - Vaarhorst,Anika A M, AU - de Craen,Anton J M, AU - Willemsen,Gonneke, AU - Slagboom,P Eline, AU - Boomsma,Dorret I, Y1 - 2013/08/28/ PY - 2013/8/30/entrez PY - 2013/8/30/pubmed PY - 2016/4/24/medline SP - 948 EP - 61 JF - Twin research and human genetics : the official journal of the International Society for Twin Studies JO - Twin Res Hum Genet VL - 16 IS - 5 N2 - Metabolomics is the comprehensive study of metabolites, which are the substrates, intermediate, and end products of cellular metabolism. The heritability of the concentrations of circulating metabolites bears relevance for evaluating their suitability as biomarkers for disease. We report aspects of familial resemblance for the concentrations in human serum of more than 100 metabolites, measured using a targeted metabolomics platform. Age- and sex-corrected monozygotic twin correlations, midparent-offspring regression coefficients, and spouse correlations in subjects from two independent cohorts (Netherlands Twin Register and Leiden Longevity Study) were estimated for each metabolite. In the Netherlands Twin Register subjects, who were largely fasting, we found significant monozygotic twin correlations for 121 out of 123 metabolites. Heritability was confirmed by midparent-offspring regression. For most detected metabolites, the correlations between spouses were considerably lower than those between twins, indicating a contribution of genetic effects to familial resemblance. Remarkably high heritability was observed for free carnitine (monozygotic twin correlation 0.66), for the amino acids serine (monozygotic twin correlation 0.77) and threonine (monozygotic twin correlation 0.64), and for phosphatidylcholine acyl-alkyl C40:3 (monozygotic twin correlation 0.77). For octenoylcarnitine, a consistent point estimate of approximately 0.50 was found for the spouse correlations in the two cohorts as well as for the monozygotic twin correlation, suggesting that familiality for this metabolite is explained by shared environment. We conclude that for the majority of metabolites targeted by the used metabolomics platform, the familial resemblance of serum concentrations is largely genetic. Our results contribute to the knowledge of the heritability of fasting serum metabolite concentrations, which is relevant for biomarker research. SN - 1832-4274 UR - https://www.unboundmedicine.com/medline/citation/23985338/Familial_resemblance_for_serum_metabolite_concentrations_ L2 - https://www.cambridge.org/core/product/identifier/S1832427413000595/type/journal_article DB - PRIME DP - Unbound Medicine ER -