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High-dose thiamine as initial treatment for Parkinson's disease.
BMJ Case Rep. 2013 Aug 28; 2013BC

Abstract

Parkinson's disease (PD) is a systemic disease with motor and non-motor deficits. We recruited three patients with newly diagnosed PD. They were not under anti-Parkinson's therapy. Plasmatic thiamine was within healthy reference range. We performed the Unified Parkinson's Disease Rating Scale (UPDRS) and started a parenteral therapy with high doses of thiamine. The therapy led to a considerable improvement in the motor part of the UPDRS ranging from 31.3% to 77.3%. From this clinical observation, it is reasonable to infer that a focal, severe thiamine deficiency due to a dysfunction of thiamine metabolism could cause a selective neuronal damage in the centres that are typically hit in this disease. Injection of high doses of thiamine was effective in reversing the symptoms, suggesting that the abnormalities in thiamine-dependent processes could be overcome by diffusion-mediated transport at supranormal thiamine concentrations.

Authors+Show Affiliations

Department of Neurological Rehabilitation, Villa Immacolata, Viterbo, Italy. carapetata@libero.itNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

23986125

Citation

Costantini, Antonio, et al. "High-dose Thiamine as Initial Treatment for Parkinson's Disease." BMJ Case Reports, vol. 2013, 2013.
Costantini A, Pala MI, Compagnoni L, et al. High-dose thiamine as initial treatment for Parkinson's disease. BMJ Case Rep. 2013;2013.
Costantini, A., Pala, M. I., Compagnoni, L., & Colangeli, M. (2013). High-dose thiamine as initial treatment for Parkinson's disease. BMJ Case Reports, 2013. https://doi.org/10.1136/bcr-2013-009289
Costantini A, et al. High-dose Thiamine as Initial Treatment for Parkinson's Disease. BMJ Case Rep. 2013 Aug 28;2013 PubMed PMID: 23986125.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - High-dose thiamine as initial treatment for Parkinson's disease. AU - Costantini,Antonio, AU - Pala,Maria Immacolata, AU - Compagnoni,Laura, AU - Colangeli,Marco, Y1 - 2013/08/28/ PY - 2013/8/30/entrez PY - 2013/8/30/pubmed PY - 2014/3/29/medline JF - BMJ case reports JO - BMJ Case Rep VL - 2013 N2 - Parkinson's disease (PD) is a systemic disease with motor and non-motor deficits. We recruited three patients with newly diagnosed PD. They were not under anti-Parkinson's therapy. Plasmatic thiamine was within healthy reference range. We performed the Unified Parkinson's Disease Rating Scale (UPDRS) and started a parenteral therapy with high doses of thiamine. The therapy led to a considerable improvement in the motor part of the UPDRS ranging from 31.3% to 77.3%. From this clinical observation, it is reasonable to infer that a focal, severe thiamine deficiency due to a dysfunction of thiamine metabolism could cause a selective neuronal damage in the centres that are typically hit in this disease. Injection of high doses of thiamine was effective in reversing the symptoms, suggesting that the abnormalities in thiamine-dependent processes could be overcome by diffusion-mediated transport at supranormal thiamine concentrations. SN - 1757-790X UR - https://www.unboundmedicine.com/medline/citation/23986125/High_dose_thiamine_as_initial_treatment_for_Parkinson's_disease_ L2 - https://casereports.bmj.com/lookup/pmidlookup?view=long&pmid=23986125 DB - PRIME DP - Unbound Medicine ER -