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Ultrasound measurements of carotid intima-media thickness and plaque in HIV-infected patients on the Mediterranean diet.
Croat Med J 2013; 54(4):330-8CM

Abstract

AIM

To evaluate the influence of food habits, specifically adherence to the Mediterranean diet, on carotid intima-media thickness (CIMT) and the presence of plaques in HIV-infected patients taking antiretroviral therapy (ART) and non-HIV-infected participants and to determine if HIV infection contributes independently to subclinical atherosclerosis.

METHODS

We conducted a cross-sectional study of 110 HIV-infected patients on ART and 131 non-HIV-infected participants at the University Hospital for Infectious Diseases in Zagreb, Croatia, from 2009-2011. CIMT measurement and determination of carotid plaque presence was detected by ultrasound. Adherence to the Mediterranean diet was assessed by a 14-point food-item questionnaire. Subclinical atherosclerosis was defined by CIMT≥0.9 mm or ≥1 carotid plaque.

RESULTS

In HIV-infected patients, subclinical atherosclerosis was associated with older age (Plt;0.001; Mann-Whitney test), higher body mass index (P=0.051; Mann-Whitney test), hypertension (Plt;0.001; χ(2) test), and a lower Mediterranean diet score (P=0.035; Mann-Whitney test), and in non-HIV-infected participants with older age (P lt; 0.001; Mann-Whitney test) and hypertension (P=0.006; χ(2) test). Multivariate analysis showed that decreased adherence to the Mediterranean diet was associated with higher odds of subclinical atherosclerosis (odds ratio [OR] 2.28, 95% confidence interval [CI] 1.10-4.72, P=0.027) as was current smoking (OR 2.86, 95% CI 1.28-6.40), hypertension (OR 3.04, 95% CI 1.41-6.57), and male sex (OR 2.35, 95% CI 0.97-5.70). There was a significant interaction of age and HIV status, suggesting that older HIV-infected patients had higher odds of subclinical atherosclerosis than controls (OR 3.28, 95% CI 1.24-8.71, P=0.017 at the age of 60 years).

CONCLUSION

We confirmed the association between lower adherence to the Mediterranean diet and increased risk of subclinical atherosclerosis and found that treated HIV infection was a risk factor for subclinical atherosclerosis in older individuals.

Authors+Show Affiliations

Klaudija Viskovic, Department of Radiology and Ultrasound, University Hospital for Infectious Diseases, 10 000 Zagreb, Croatia, viskovick@gmail.com.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23986273

Citation

Višković, Klaudija, et al. "Ultrasound Measurements of Carotid Intima-media Thickness and Plaque in HIV-infected Patients On the Mediterranean Diet." Croatian Medical Journal, vol. 54, no. 4, 2013, pp. 330-8.
Višković K, Rutherford GW, Sudario G, et al. Ultrasound measurements of carotid intima-media thickness and plaque in HIV-infected patients on the Mediterranean diet. Croat Med J. 2013;54(4):330-8.
Višković, K., Rutherford, G. W., Sudario, G., Stemberger, L., Brnić, Z., & Begovac, J. (2013). Ultrasound measurements of carotid intima-media thickness and plaque in HIV-infected patients on the Mediterranean diet. Croatian Medical Journal, 54(4), pp. 330-8.
Višković K, et al. Ultrasound Measurements of Carotid Intima-media Thickness and Plaque in HIV-infected Patients On the Mediterranean Diet. Croat Med J. 2013;54(4):330-8. PubMed PMID: 23986273.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ultrasound measurements of carotid intima-media thickness and plaque in HIV-infected patients on the Mediterranean diet. AU - Višković,Klaudija, AU - Rutherford,George W, AU - Sudario,Gabriel, AU - Stemberger,Lorna, AU - Brnić,Zoran, AU - Begovac,Josip, PY - 2013/8/30/entrez PY - 2013/8/30/pubmed PY - 2013/12/16/medline SP - 330 EP - 8 JF - Croatian medical journal JO - Croat. Med. J. VL - 54 IS - 4 N2 - AIM: To evaluate the influence of food habits, specifically adherence to the Mediterranean diet, on carotid intima-media thickness (CIMT) and the presence of plaques in HIV-infected patients taking antiretroviral therapy (ART) and non-HIV-infected participants and to determine if HIV infection contributes independently to subclinical atherosclerosis. METHODS: We conducted a cross-sectional study of 110 HIV-infected patients on ART and 131 non-HIV-infected participants at the University Hospital for Infectious Diseases in Zagreb, Croatia, from 2009-2011. CIMT measurement and determination of carotid plaque presence was detected by ultrasound. Adherence to the Mediterranean diet was assessed by a 14-point food-item questionnaire. Subclinical atherosclerosis was defined by CIMT≥0.9 mm or ≥1 carotid plaque. RESULTS: In HIV-infected patients, subclinical atherosclerosis was associated with older age (Plt;0.001; Mann-Whitney test), higher body mass index (P=0.051; Mann-Whitney test), hypertension (Plt;0.001; χ(2) test), and a lower Mediterranean diet score (P=0.035; Mann-Whitney test), and in non-HIV-infected participants with older age (P lt; 0.001; Mann-Whitney test) and hypertension (P=0.006; χ(2) test). Multivariate analysis showed that decreased adherence to the Mediterranean diet was associated with higher odds of subclinical atherosclerosis (odds ratio [OR] 2.28, 95% confidence interval [CI] 1.10-4.72, P=0.027) as was current smoking (OR 2.86, 95% CI 1.28-6.40), hypertension (OR 3.04, 95% CI 1.41-6.57), and male sex (OR 2.35, 95% CI 0.97-5.70). There was a significant interaction of age and HIV status, suggesting that older HIV-infected patients had higher odds of subclinical atherosclerosis than controls (OR 3.28, 95% CI 1.24-8.71, P=0.017 at the age of 60 years). CONCLUSION: We confirmed the association between lower adherence to the Mediterranean diet and increased risk of subclinical atherosclerosis and found that treated HIV infection was a risk factor for subclinical atherosclerosis in older individuals. SN - 1332-8166 UR - https://www.unboundmedicine.com/medline/citation/23986273/Ultrasound_measurements_of_carotid_intima_media_thickness_and_plaque_in_HIV_infected_patients_on_the_Mediterranean_diet_ L2 - http://www.cmj.hr/2013/54/4/23986273.htm DB - PRIME DP - Unbound Medicine ER -