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Intake of specific nonfermented soy foods may be inversely associated with risk of distal gastric cancer in a Chinese population.
J Nutr. 2013 Nov; 143(11):1736-42.JN

Abstract

Because the association between soy consumption and gastric cancer is inconsistent, we evaluated the putative preventive effect of soy food on gastric cancer risk in the Shanghai Women's and Men's Health Studies, comprising a total of 128,687 participants. Intake of nonfermented soy foods was estimated using 2 validated food-frequency questionnaires. HRs were calculated with 95% CIs for intake amounts of total nonfermented soy food intake, soy protein, and isoflavones as well as individual soy food groups using Cox proportional hazards regression. A total of 493 distal gastric cancer cases were identified by 2010. Although all risk estimates for summary measures of soy food intake above the lowest quartile (quartile 1) were suggestive of a protective effect, no statistically significant associations with risk of distal gastric cancer were found. Among the separate soy food groups, significant reductions in risk of distal gastric cancer by increasing intake of tofu were found in men in quartile 2 (HR: 0.59; 95% CI: 0.40, 0.86), quartile 3 (HR: 0.62; 95% CI: 0.44, 0.88), and quartile 4 (HR: 0.64; 95% CI: 0.42, 0.99), resulting in a significant trend (P-trend = 0.02). Dry bean intake was also inversely associated with decreased risk of gastric cancer, but in postmenopausal women only [quartile 2 (HR: 0.54; 95% CI: 0.30, 0.96); quartile 3 (HR: 0.90; 95% CI: 0.64, 1.27); and quartile 4 (HR: 0.63; 95% CI: 0.43, 0.91)], resulting in a significant trend (P-trend = 0.03). Overall, our study found no statistically significant association between nonfermented soy food intake and distal gastric cancer risk, though the data supported the hypothesis that tofu may protect against distal gastric cancer in men and dry bean consumption may decrease the risk of gastric cancer in postmenopausal women.

Authors+Show Affiliations

Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

23986366

Citation

Kweon, Sun-Seog, et al. "Intake of Specific Nonfermented Soy Foods May Be Inversely Associated With Risk of Distal Gastric Cancer in a Chinese Population." The Journal of Nutrition, vol. 143, no. 11, 2013, pp. 1736-42.
Kweon SS, Shu XO, Xiang Y, et al. Intake of specific nonfermented soy foods may be inversely associated with risk of distal gastric cancer in a Chinese population. J Nutr. 2013;143(11):1736-42.
Kweon, S. S., Shu, X. O., Xiang, Y., Cai, H., Yang, G., Ji, B. T., Li, H., Gao, Y. T., Zheng, W., & Epplein, M. (2013). Intake of specific nonfermented soy foods may be inversely associated with risk of distal gastric cancer in a Chinese population. The Journal of Nutrition, 143(11), 1736-42. https://doi.org/10.3945/jn.113.177675
Kweon SS, et al. Intake of Specific Nonfermented Soy Foods May Be Inversely Associated With Risk of Distal Gastric Cancer in a Chinese Population. J Nutr. 2013;143(11):1736-42. PubMed PMID: 23986366.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Intake of specific nonfermented soy foods may be inversely associated with risk of distal gastric cancer in a Chinese population. AU - Kweon,Sun-Seog, AU - Shu,Xiao-Ou, AU - Xiang,Yongbing, AU - Cai,Hui, AU - Yang,Gong, AU - Ji,Bu-Tian, AU - Li,Honglan, AU - Gao,Yu-Tang, AU - Zheng,Wei, AU - Epplein,Meira, Y1 - 2013/08/28/ PY - 2013/8/30/entrez PY - 2013/8/30/pubmed PY - 2013/12/18/medline SP - 1736 EP - 42 JF - The Journal of nutrition JO - J Nutr VL - 143 IS - 11 N2 - Because the association between soy consumption and gastric cancer is inconsistent, we evaluated the putative preventive effect of soy food on gastric cancer risk in the Shanghai Women's and Men's Health Studies, comprising a total of 128,687 participants. Intake of nonfermented soy foods was estimated using 2 validated food-frequency questionnaires. HRs were calculated with 95% CIs for intake amounts of total nonfermented soy food intake, soy protein, and isoflavones as well as individual soy food groups using Cox proportional hazards regression. A total of 493 distal gastric cancer cases were identified by 2010. Although all risk estimates for summary measures of soy food intake above the lowest quartile (quartile 1) were suggestive of a protective effect, no statistically significant associations with risk of distal gastric cancer were found. Among the separate soy food groups, significant reductions in risk of distal gastric cancer by increasing intake of tofu were found in men in quartile 2 (HR: 0.59; 95% CI: 0.40, 0.86), quartile 3 (HR: 0.62; 95% CI: 0.44, 0.88), and quartile 4 (HR: 0.64; 95% CI: 0.42, 0.99), resulting in a significant trend (P-trend = 0.02). Dry bean intake was also inversely associated with decreased risk of gastric cancer, but in postmenopausal women only [quartile 2 (HR: 0.54; 95% CI: 0.30, 0.96); quartile 3 (HR: 0.90; 95% CI: 0.64, 1.27); and quartile 4 (HR: 0.63; 95% CI: 0.43, 0.91)], resulting in a significant trend (P-trend = 0.03). Overall, our study found no statistically significant association between nonfermented soy food intake and distal gastric cancer risk, though the data supported the hypothesis that tofu may protect against distal gastric cancer in men and dry bean consumption may decrease the risk of gastric cancer in postmenopausal women. SN - 1541-6100 UR - https://www.unboundmedicine.com/medline/citation/23986366/Intake_of_specific_nonfermented_soy_foods_may_be_inversely_associated_with_risk_of_distal_gastric_cancer_in_a_Chinese_population_ L2 - https://academic.oup.com/jn/article-lookup/doi/10.3945/jn.113.177675 DB - PRIME DP - Unbound Medicine ER -