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Preparation and in vitro evaluation of xanthan gum facilitated superabsorbent polymeric microspheres.
Carbohydr Polym. 2013 Oct 15; 98(1):64-72.CP

Abstract

Interpenetrating polymer network (IPN) hydrogel microspheres of xanthan gum (XG) based superabsorbent polymer (SAP) and poly(vinyl alcohol) (PVA) were prepared by water-in-oil (w/o) emulsion crosslinking method for sustained release of ciprofloxacin hydrochloride (CIPRO). The microspheres were prepared with various ratios of hydrolyzed SAP to PVA and extent of crosslinking density. The prepared microspheres with loose and rigid surfaces were evidenced by scanning electron microscope (SEM). Fourier transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD) analysis confirmed the IPN formation. Differential scanning calorimetry (DSC) study was performed to understand the dispersion nature of drug after encapsulation. The in vitro drug release study was extensively evaluated depending on the process variables in both acidic and alkaline media. All the formulations exhibited satisfactory physicochemical and in vitro release characteristics. Release data indicated a non-Fickian trend of drug release from the formulations. Based on the results, this study suggest that CIPRO loaded IPN microspheres were suitable for sustained release application.

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Authors+Show Affiliations

Bhattacharya SS
School of Pharmaceutical Sciences, IFTM University, Delhi Road, Moradabad 244001, Uttar Pradesh, India. shivsankar.bhattacharya@gmail.com
Mazahir F
No affiliation info available
Banerjee S
No affiliation info available
Verma A
No affiliation info available
Ghosh A
No affiliation info available

MeSH

AbsorptionCiprofloxacinDrug CarriersKineticsMicrospheresOilsPolysaccharides, BacterialPolyvinyl AlcoholSolubilitySurface PropertiesWater

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23987317

Citation

Bhattacharya, Shiv Sankar, et al. "Preparation and in Vitro Evaluation of Xanthan Gum Facilitated Superabsorbent Polymeric Microspheres." Carbohydrate Polymers, vol. 98, no. 1, 2013, pp. 64-72.
Bhattacharya SS, Mazahir F, Banerjee S, et al. Preparation and in vitro evaluation of xanthan gum facilitated superabsorbent polymeric microspheres. Carbohydr Polym. 2013;98(1):64-72.
Bhattacharya, S. S., Mazahir, F., Banerjee, S., Verma, A., & Ghosh, A. (2013). Preparation and in vitro evaluation of xanthan gum facilitated superabsorbent polymeric microspheres. Carbohydrate Polymers, 98(1), 64-72. https://doi.org/10.1016/j.carbpol.2013.05.011
Bhattacharya SS, et al. Preparation and in Vitro Evaluation of Xanthan Gum Facilitated Superabsorbent Polymeric Microspheres. Carbohydr Polym. 2013 Oct 15;98(1):64-72. PubMed PMID: 23987317.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Preparation and in vitro evaluation of xanthan gum facilitated superabsorbent polymeric microspheres. AU - Bhattacharya,Shiv Sankar, AU - Mazahir,Farhan, AU - Banerjee,Subham, AU - Verma,Anurag, AU - Ghosh,Amitava, Y1 - 2013/05/15/ PY - 2013/03/08/received PY - 2013/04/23/revised PY - 2013/05/09/accepted PY - 2013/8/31/entrez PY - 2013/8/31/pubmed PY - 2014/3/29/medline KW - AA KW - APS KW - CIPRO KW - Ciprofloxacin hydrochloride KW - DEE KW - DSC KW - Emulsion crosslinking KW - FTIR KW - GA KW - IPN KW - Interpenetrating polymer network KW - KBr KW - MBA KW - N,N′-methylenebisacrylamide KW - PVA KW - Poly(vinyl alcohol) KW - SAP KW - SEM KW - Superabsorbent polymer KW - UV–Vis KW - X-ray diffraction KW - XG KW - XRD KW - Xanthan gum KW - acrylic acid KW - ammonium persulfate KW - ciprofloxacin hydrochloride KW - differential scanning calorimetry KW - drug encapsulation efficiency KW - fourier transform infra-red KW - glutaraldehyde KW - interpenetrating polymer network KW - poly (vinyl alcohol) KW - potassium bromide KW - scanning electron microscopy KW - superabsorbent polymer KW - ultraviolet–visible KW - w/o KW - water-in-oil KW - xanthan gum SP - 64 EP - 72 JF - Carbohydrate polymers JO - Carbohydr Polym VL - 98 IS - 1 N2 - Interpenetrating polymer network (IPN) hydrogel microspheres of xanthan gum (XG) based superabsorbent polymer (SAP) and poly(vinyl alcohol) (PVA) were prepared by water-in-oil (w/o) emulsion crosslinking method for sustained release of ciprofloxacin hydrochloride (CIPRO). The microspheres were prepared with various ratios of hydrolyzed SAP to PVA and extent of crosslinking density. The prepared microspheres with loose and rigid surfaces were evidenced by scanning electron microscope (SEM). Fourier transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD) analysis confirmed the IPN formation. Differential scanning calorimetry (DSC) study was performed to understand the dispersion nature of drug after encapsulation. The in vitro drug release study was extensively evaluated depending on the process variables in both acidic and alkaline media. All the formulations exhibited satisfactory physicochemical and in vitro release characteristics. Release data indicated a non-Fickian trend of drug release from the formulations. Based on the results, this study suggest that CIPRO loaded IPN microspheres were suitable for sustained release application. SN - 1879-1344 UR - https://www.unboundmedicine.com/medline/citation/23987317/Preparation_and_in_vitro_evaluation_of_xanthan_gum_facilitated_superabsorbent_polymeric_microspheres_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0144-8617(13)00486-4 DB - PRIME DP - Unbound Medicine ER -