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Microwave assisted synthesis of acrylamide grafted locust bean gum and its application in drug delivery.
Carbohydr Polym. 2013 Oct 15; 98(1):1083-94.CP

Abstract

Acrylamide grafted copolymer of locust bean gum was prepared by microwave irradiation using ceric ammonium nitrate as redox initiator. The grafting process was optimized in terms of irradiation time, amount of initiator and acrylamide by using constant amount of native locust bean gum. The grafted gum was characterized by Fourier transform infrared spectroscopy (FT-IR), (13)C nuclear magnetic resonance (NMR), scanning electron microscopy (SEM), X-ray diffraction study (XRD), differential scanning calorimetry (DSC), elemental analysis, contact angle, viscosity, molecular weight, swelling and biodegradability studies. The grafted gum was found to be biodegradable and non-toxic. It was further used to prepare controlled-release matrix tablet of buflomedil hydrochloride. The in vitro release profile of the tablet showed the rate controlling property of acrylamide grafted locust bean gum was similar to that of hydroxypropyl methylcellulose (HPMC-K15M).

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Publisher Full Text (DOI)

Authors+Show Affiliations

Kaity S
Department of Pharmaceutical Sciences, Birla Institute of Technology, Mesra, Ranchi 835215, India.
Isaac J
No affiliation info available
Kumar PM
No affiliation info available
Bose A
No affiliation info available
Wong TW
No affiliation info available
Ghosh A
No affiliation info available

MeSH

AcrylamideAnimalsChemistry Techniques, SyntheticDrug CarriersFemaleGalactansHalf-LifeMannansMiceMicrowavesPlant GumsPyrrolidinesSolubilityToxicity TestsViscosityWater

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23987450

Citation

Kaity, Santanu, et al. "Microwave Assisted Synthesis of Acrylamide Grafted Locust Bean Gum and Its Application in Drug Delivery." Carbohydrate Polymers, vol. 98, no. 1, 2013, pp. 1083-94.
Kaity S, Isaac J, Kumar PM, et al. Microwave assisted synthesis of acrylamide grafted locust bean gum and its application in drug delivery. Carbohydr Polym. 2013;98(1):1083-94.
Kaity, S., Isaac, J., Kumar, P. M., Bose, A., Wong, T. W., & Ghosh, A. (2013). Microwave assisted synthesis of acrylamide grafted locust bean gum and its application in drug delivery. Carbohydrate Polymers, 98(1), 1083-94. https://doi.org/10.1016/j.carbpol.2013.07.037
Kaity S, et al. Microwave Assisted Synthesis of Acrylamide Grafted Locust Bean Gum and Its Application in Drug Delivery. Carbohydr Polym. 2013 Oct 15;98(1):1083-94. PubMed PMID: 23987450.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Microwave assisted synthesis of acrylamide grafted locust bean gum and its application in drug delivery. AU - Kaity,Santanu, AU - Isaac,Jinu, AU - Kumar,P Mahesh, AU - Bose,Anirbandeep, AU - Wong,Tin Wui, AU - Ghosh,Animesh, Y1 - 2013/07/18/ PY - 2013/04/26/received PY - 2013/06/24/revised PY - 2013/07/13/accepted PY - 2013/8/31/entrez PY - 2013/8/31/pubmed PY - 2014/3/29/medline KW - Acrylamide grafted locust bean gum KW - Am KW - Am-g-LBG KW - BH KW - Biodegradable KW - Buflomedil hydrochloride KW - C KW - CAN KW - Controlled-release KW - DSC KW - FTIR KW - Fourier transform infrared KW - HPMC KW - KBr KW - LBG KW - N KW - O KW - SEM KW - UV–vis KW - X-ray diffraction KW - XRD KW - acrylamide KW - acrylamide grafted locust bean gum KW - buflomedil hydrochloride KW - carbon KW - ceric ammonium nitrate KW - differential scanning calorimetry KW - hydroxypropyl methylcellulose KW - locust bean gum KW - nitrogen KW - oxygen KW - potassium bromide KW - scanning electron microscopy KW - ultraviolet–visible SP - 1083 EP - 94 JF - Carbohydrate polymers JO - Carbohydr Polym VL - 98 IS - 1 N2 - Acrylamide grafted copolymer of locust bean gum was prepared by microwave irradiation using ceric ammonium nitrate as redox initiator. The grafting process was optimized in terms of irradiation time, amount of initiator and acrylamide by using constant amount of native locust bean gum. The grafted gum was characterized by Fourier transform infrared spectroscopy (FT-IR), (13)C nuclear magnetic resonance (NMR), scanning electron microscopy (SEM), X-ray diffraction study (XRD), differential scanning calorimetry (DSC), elemental analysis, contact angle, viscosity, molecular weight, swelling and biodegradability studies. The grafted gum was found to be biodegradable and non-toxic. It was further used to prepare controlled-release matrix tablet of buflomedil hydrochloride. The in vitro release profile of the tablet showed the rate controlling property of acrylamide grafted locust bean gum was similar to that of hydroxypropyl methylcellulose (HPMC-K15M). SN - 1879-1344 UR - https://www.unboundmedicine.com/medline/citation/23987450/Microwave_assisted_synthesis_of_acrylamide_grafted_locust_bean_gum_and_its_application_in_drug_delivery_ DB - PRIME DP - Unbound Medicine ER -