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Plasmodium falciparum infection during dry season: IgG responses to Anopheles gambiae salivary gSG6-P1 peptide as sensitive biomarker for malaria risk in Northern Senegal.
Malar J. 2013 Aug 30; 12:301.MJ

Abstract

BACKGROUND

The Northern part of Senegal is characterized by a low and seasonal transmission of malaria. However, some Plasmodium falciparum infections and malaria clinical cases are reported during the dry season. This study aims to assess the relationship between IgG antibody (Ab) responses to gSG6-P1 mosquito salivary peptide and the prevalence of P. falciparum infection in children during the dry season in the Senegal River Valley. The positive association of the Ab response to gSG6-P1, as biomarker of human exposure to Anopheles vector bite, and P. falciparum infectious status (uninfected, infected-asymptomatic or infected-symptomatic) will allow considering this biomarker as a potential indicator of P. falciparum infection risk during the dry season.

METHODS

Microscopic examination of thick blood smears was performed in 371 and 310 children at the start (January) and at the end (June) of the dry season, respectively, in order to assess the prevalence of P. falciparum infection. Collected sera were used to evaluate IgG response to gSG6-P1 by ELISA. Association between parasitological and clinical data (infected-asymptomatic or infected-symptomatic) and the anti-gSG6-P1 IgG levels were evaluated during this period.

RESULTS

The prevalence of P. falciparum infection was very low to moderate according to the studied period and was higher in January (23.5%) compared to June (3.5%). Specific IgG response was also different between uninfected children and asymptomatic carriers of the parasite. Children with P. falciparum infection in the dry season showed higher IgG Ab levels to gSG6-P1 than uninfected children.

CONCLUSIONS

The results strengthen the hypothesis that malaria transmission is maintained during the dry season in an area of low and seasonal transmission. The measurement of IgG responses to gSG6-P1 salivary peptide could be a pertinent indicator of human malaria reservoir or infection risk in this particular epidemiological context. This promising immunological marker could be useful for the evaluation of the risk of P. falciparum exposure observed during dry season and, by consequences, could be used for the survey of potential pre-elimination situation.

Authors+Show Affiliations

Centre de Recherche Biomédicale Espoir Pour La Santé, 269 Route de la corniche, Sor, BP: 226, Saint-Louis, Sénégal. andre.sagna@espoir-sante.org.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23988032

Citation

Sagna, André B., et al. "Plasmodium Falciparum Infection During Dry Season: IgG Responses to Anopheles Gambiae Salivary gSG6-P1 Peptide as Sensitive Biomarker for Malaria Risk in Northern Senegal." Malaria Journal, vol. 12, 2013, p. 301.
Sagna AB, Gaayeb L, Sarr JB, et al. Plasmodium falciparum infection during dry season: IgG responses to Anopheles gambiae salivary gSG6-P1 peptide as sensitive biomarker for malaria risk in Northern Senegal. Malar J. 2013;12:301.
Sagna, A. B., Gaayeb, L., Sarr, J. B., Senghor, S., Poinsignon, A., Boutouaba-Combe, S., Schacht, A. M., Hermann, E., Faye, N., Remoue, F., & Riveau, G. (2013). Plasmodium falciparum infection during dry season: IgG responses to Anopheles gambiae salivary gSG6-P1 peptide as sensitive biomarker for malaria risk in Northern Senegal. Malaria Journal, 12, 301. https://doi.org/10.1186/1475-2875-12-301
Sagna AB, et al. Plasmodium Falciparum Infection During Dry Season: IgG Responses to Anopheles Gambiae Salivary gSG6-P1 Peptide as Sensitive Biomarker for Malaria Risk in Northern Senegal. Malar J. 2013 Aug 30;12:301. PubMed PMID: 23988032.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Plasmodium falciparum infection during dry season: IgG responses to Anopheles gambiae salivary gSG6-P1 peptide as sensitive biomarker for malaria risk in Northern Senegal. AU - Sagna,André B, AU - Gaayeb,Lobna, AU - Sarr,Jean B, AU - Senghor,Simon, AU - Poinsignon,Anne, AU - Boutouaba-Combe,Samy, AU - Schacht,Anne-Marie, AU - Hermann,Emmanuel, AU - Faye,Ngor, AU - Remoue,Franck, AU - Riveau,Gilles, Y1 - 2013/08/30/ PY - 2013/06/26/received PY - 2013/08/27/accepted PY - 2013/8/31/entrez PY - 2013/8/31/pubmed PY - 2014/7/16/medline SP - 301 EP - 301 JF - Malaria journal JO - Malar J VL - 12 N2 - BACKGROUND: The Northern part of Senegal is characterized by a low and seasonal transmission of malaria. However, some Plasmodium falciparum infections and malaria clinical cases are reported during the dry season. This study aims to assess the relationship between IgG antibody (Ab) responses to gSG6-P1 mosquito salivary peptide and the prevalence of P. falciparum infection in children during the dry season in the Senegal River Valley. The positive association of the Ab response to gSG6-P1, as biomarker of human exposure to Anopheles vector bite, and P. falciparum infectious status (uninfected, infected-asymptomatic or infected-symptomatic) will allow considering this biomarker as a potential indicator of P. falciparum infection risk during the dry season. METHODS: Microscopic examination of thick blood smears was performed in 371 and 310 children at the start (January) and at the end (June) of the dry season, respectively, in order to assess the prevalence of P. falciparum infection. Collected sera were used to evaluate IgG response to gSG6-P1 by ELISA. Association between parasitological and clinical data (infected-asymptomatic or infected-symptomatic) and the anti-gSG6-P1 IgG levels were evaluated during this period. RESULTS: The prevalence of P. falciparum infection was very low to moderate according to the studied period and was higher in January (23.5%) compared to June (3.5%). Specific IgG response was also different between uninfected children and asymptomatic carriers of the parasite. Children with P. falciparum infection in the dry season showed higher IgG Ab levels to gSG6-P1 than uninfected children. CONCLUSIONS: The results strengthen the hypothesis that malaria transmission is maintained during the dry season in an area of low and seasonal transmission. The measurement of IgG responses to gSG6-P1 salivary peptide could be a pertinent indicator of human malaria reservoir or infection risk in this particular epidemiological context. This promising immunological marker could be useful for the evaluation of the risk of P. falciparum exposure observed during dry season and, by consequences, could be used for the survey of potential pre-elimination situation. SN - 1475-2875 UR - https://www.unboundmedicine.com/medline/citation/23988032/Plasmodium_falciparum_infection_during_dry_season:_IgG_responses_to_Anopheles_gambiae_salivary_gSG6_P1_peptide_as_sensitive_biomarker_for_malaria_risk_in_Northern_Senegal_ L2 - https://malariajournal.biomedcentral.com/articles/10.1186/1475-2875-12-301 DB - PRIME DP - Unbound Medicine ER -