Tags

Type your tag names separated by a space and hit enter

Potential use of optical coherence tomography and high-frequency ultrasound for the assessment of nail disease in psoriasis and psoriatic arthritis.
Dermatology. 2013; 227(1):45-51.D

Abstract

BACKGROUND/OBJECTIVE

Psoriatic nail disease is increasingly recognised to be of major clinical and research relevance. Clinical assessment remains the current gold standard for its evaluation.

OBJECTIVE

We compared optical coherence tomography (OCT) and ultrasound (US) for nail disease assessment in psoriatic disease.

METHODS

18 patients with at least one involved nail and 12 healthy controls were scanned using OCT; psoriatic patients also had an US scan (using a linear probe at 9-14 MHz). Nail and contour abnormalities were documented. Clinical onychopathy was scored independently using the modified Nail Psoriasis Severity Index.

RESULTS

Among 180 nails, 67.8% had clinical findings whereas 33.9% were abnormal by US and 44.4% had abnormalities on OCT. A positive OCT had a sensitivity and specificity of 44.4 and 95.8%, respectively, with a positive likelihood ratio of 10.7 for nail disease. OCT demonstrated 76.3% absolute agreement compared with clinical assessment and 65% with US. OCT detected subtle abnormalities in 12 clinically normal nails and in 41 nails with normal US findings.

CONCLUSION

These findings show that OCT has a potential for the systematic characterisation of psoriatic nail changes and could be useful in diagnosis and more objective assessment of treatment response.

Authors+Show Affiliations

Istanbul Medeniyet University, Goztepe Training and Research Hospital, Istanbul, Turkey.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23988587

Citation

Aydin, Sibel Z., et al. "Potential Use of Optical Coherence Tomography and High-frequency Ultrasound for the Assessment of Nail Disease in Psoriasis and Psoriatic Arthritis." Dermatology (Basel, Switzerland), vol. 227, no. 1, 2013, pp. 45-51.
Aydin SZ, Castillo-Gallego C, Ash ZR, et al. Potential use of optical coherence tomography and high-frequency ultrasound for the assessment of nail disease in psoriasis and psoriatic arthritis. Dermatology (Basel). 2013;227(1):45-51.
Aydin, S. Z., Castillo-Gallego, C., Ash, Z. R., Abignano, G., Marzo-Ortega, H., Wittmann, M., Del Galdo, F., & McGonagle, D. (2013). Potential use of optical coherence tomography and high-frequency ultrasound for the assessment of nail disease in psoriasis and psoriatic arthritis. Dermatology (Basel, Switzerland), 227(1), 45-51. https://doi.org/10.1159/000351702
Aydin SZ, et al. Potential Use of Optical Coherence Tomography and High-frequency Ultrasound for the Assessment of Nail Disease in Psoriasis and Psoriatic Arthritis. Dermatology (Basel). 2013;227(1):45-51. PubMed PMID: 23988587.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Potential use of optical coherence tomography and high-frequency ultrasound for the assessment of nail disease in psoriasis and psoriatic arthritis. AU - Aydin,Sibel Z, AU - Castillo-Gallego,Concepción, AU - Ash,Zoe R, AU - Abignano,Giuseppina, AU - Marzo-Ortega,Helena, AU - Wittmann,Miriam, AU - Del Galdo,Francesco, AU - McGonagle,Dennis, Y1 - 2013/08/24/ PY - 2012/12/26/received PY - 2013/04/19/accepted PY - 2013/8/31/entrez PY - 2013/8/31/pubmed PY - 2014/6/16/medline SP - 45 EP - 51 JF - Dermatology (Basel, Switzerland) JO - Dermatology (Basel) VL - 227 IS - 1 N2 - BACKGROUND/OBJECTIVE: Psoriatic nail disease is increasingly recognised to be of major clinical and research relevance. Clinical assessment remains the current gold standard for its evaluation. OBJECTIVE: We compared optical coherence tomography (OCT) and ultrasound (US) for nail disease assessment in psoriatic disease. METHODS: 18 patients with at least one involved nail and 12 healthy controls were scanned using OCT; psoriatic patients also had an US scan (using a linear probe at 9-14 MHz). Nail and contour abnormalities were documented. Clinical onychopathy was scored independently using the modified Nail Psoriasis Severity Index. RESULTS: Among 180 nails, 67.8% had clinical findings whereas 33.9% were abnormal by US and 44.4% had abnormalities on OCT. A positive OCT had a sensitivity and specificity of 44.4 and 95.8%, respectively, with a positive likelihood ratio of 10.7 for nail disease. OCT demonstrated 76.3% absolute agreement compared with clinical assessment and 65% with US. OCT detected subtle abnormalities in 12 clinically normal nails and in 41 nails with normal US findings. CONCLUSION: These findings show that OCT has a potential for the systematic characterisation of psoriatic nail changes and could be useful in diagnosis and more objective assessment of treatment response. SN - 1421-9832 UR - https://www.unboundmedicine.com/medline/citation/23988587/Potential_use_of_optical_coherence_tomography_and_high_frequency_ultrasound_for_the_assessment_of_nail_disease_in_psoriasis_and_psoriatic_arthritis_ L2 - https://www.karger.com?DOI=10.1159/000351702 DB - PRIME DP - Unbound Medicine ER -