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Seroprotection after hepatitis a vaccination in patients with drug-induced immunosuppression.
J Travel Med. 2013 Sep-Oct; 20(5):278-82.JT

Abstract

BACKGROUND

Increasing numbers of travelers using immunosuppressive drugs visit hepatitis A endemic countries. Data on protection rates after hepatitis A vaccination in this group are scarce.

METHODS

In this retrospective study, records of subjects with hepatitis A serology taken after vaccination were searched for in travel clinic databases. Relation between immunosuppressive drug use, age, gender, and time between vaccination and serology was evaluated.

RESULTS

Seroprotection rates within 4 weeks after primary vaccination (50%) are lower than after 4 weeks (64%). After the complete series of two vaccinations seroprotection rates reach 95% although success depends on the immunosuppressive drug being used. Subjects under anti-TNF alpha treatment have significantly lower seroprotection rates than subjects using classical immunosuppressive drugs after the second vaccination. There is no influence of age or gender on seroprotection rates.

CONCLUSIONS

Last-minute vaccination in subjects using immunosuppressive medication is not reliable, only 60% of our subjects had a protective antibody level after a single vaccination. When serology was done within 4 weeks after a single vaccination, seroprotection rates were only 50%, after 4 weeks this number rose to 64%. When persons visit a travel clinic in time for a complete vaccination series, satisfactory seroprotection rates can be reached. Seroprotection rate depends on the drug being used, persons using anti-TNF alpha are less protected.

Authors+Show Affiliations

Department of Infectious Diseases, Public Health Service (GGD) Gelre-IJssel, Apeldoorn, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23992569

Citation

van den Bijllaardt, Wouter, et al. "Seroprotection After Hepatitis a Vaccination in Patients With Drug-induced Immunosuppression." Journal of Travel Medicine, vol. 20, no. 5, 2013, pp. 278-82.
van den Bijllaardt W, Siers HM, Timmerman-Kok C, et al. Seroprotection after hepatitis a vaccination in patients with drug-induced immunosuppression. J Travel Med. 2013;20(5):278-82.
van den Bijllaardt, W., Siers, H. M., Timmerman-Kok, C., Pessers, F. G., Natrop, G., van Baars, J. F., Nutma, N., van der Werf, D., & Gisolf, E. H. (2013). Seroprotection after hepatitis a vaccination in patients with drug-induced immunosuppression. Journal of Travel Medicine, 20(5), 278-82. https://doi.org/10.1111/jtm.12050
van den Bijllaardt W, et al. Seroprotection After Hepatitis a Vaccination in Patients With Drug-induced Immunosuppression. J Travel Med. 2013 Sep-Oct;20(5):278-82. PubMed PMID: 23992569.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Seroprotection after hepatitis a vaccination in patients with drug-induced immunosuppression. AU - van den Bijllaardt,Wouter, AU - Siers,Helen M, AU - Timmerman-Kok,Caroline, AU - Pessers,Franciscus G, AU - Natrop,Gerard, AU - van Baars,Joep F, AU - Nutma,Nynke, AU - van der Werf,Douwe, AU - Gisolf,Elizabeth H, Y1 - 2013/07/09/ PY - 2012/09/25/received PY - 2013/01/11/revised PY - 2013/01/31/accepted PY - 2013/9/3/entrez PY - 2013/9/3/pubmed PY - 2014/4/26/medline SP - 278 EP - 82 JF - Journal of travel medicine JO - J Travel Med VL - 20 IS - 5 N2 - BACKGROUND: Increasing numbers of travelers using immunosuppressive drugs visit hepatitis A endemic countries. Data on protection rates after hepatitis A vaccination in this group are scarce. METHODS: In this retrospective study, records of subjects with hepatitis A serology taken after vaccination were searched for in travel clinic databases. Relation between immunosuppressive drug use, age, gender, and time between vaccination and serology was evaluated. RESULTS: Seroprotection rates within 4 weeks after primary vaccination (50%) are lower than after 4 weeks (64%). After the complete series of two vaccinations seroprotection rates reach 95% although success depends on the immunosuppressive drug being used. Subjects under anti-TNF alpha treatment have significantly lower seroprotection rates than subjects using classical immunosuppressive drugs after the second vaccination. There is no influence of age or gender on seroprotection rates. CONCLUSIONS: Last-minute vaccination in subjects using immunosuppressive medication is not reliable, only 60% of our subjects had a protective antibody level after a single vaccination. When serology was done within 4 weeks after a single vaccination, seroprotection rates were only 50%, after 4 weeks this number rose to 64%. When persons visit a travel clinic in time for a complete vaccination series, satisfactory seroprotection rates can be reached. Seroprotection rate depends on the drug being used, persons using anti-TNF alpha are less protected. SN - 1708-8305 UR - https://www.unboundmedicine.com/medline/citation/23992569/Seroprotection_after_hepatitis_a_vaccination_in_patients_with_drug_induced_immunosuppression_ L2 - https://academic.oup.com/jtm/article-lookup/doi/10.1111/jtm.12050 DB - PRIME DP - Unbound Medicine ER -