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Piperine reverses high fat diet-induced hepatic steatosis and insulin resistance in mice.
Food Chem 2013; 141(4):3627-35FC

Abstract

This study examined the effect of piperine on hepatic steatosis and insulin resistance induced in mice by feeding a high-fat diet (HFD) for 13 weeks and elucidated potential underlying molecular mechanisms. Administration of piperine (50 mg/kg body weight) to mice with HFD-induced hepatic steatosis resulted in a significant increase in plasma adiponectin levels. Also, elevated plasma concentrations of insulin and glucose and hepatic lipid levels induced by feeding a HFD were reversed in mice when they were administered piperine. However, piperine did not reduce body weight and other biochemical markers to an extent where they became equal to the levels found in the CD-fed mice. Piperine reversed HFD-induced down-regulation of adiponecitn-AMP-activated protein kinase (AMPK) signalling molecules which play an important role in mediating lipogenesis, fatty acid oxidation and insulin signalling in the livers of mice. The expressions of lipogenic target genes were decreased, whereas the expression of carnitine palmitoyltransferase 1 (CPT1) gene involved in fatty acid oxidation was increased in the livers of the Pin50 group. Piperine significantly decreased the phosphorylation of insulin receptor substrate-1 (IRS-1) compared with the HFD-fed mice. Administration of piperine appeared to reverse preexisting HFD-induced hepatic steatosis and insulin resistance, probably by activation of adiponectin-AMPK signalling in mice.

Authors+Show Affiliations

Department of Food and Nutrition, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul 120-749, Republic of Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23993530

Citation

Choi, Seoyoon, et al. "Piperine Reverses High Fat Diet-induced Hepatic Steatosis and Insulin Resistance in Mice." Food Chemistry, vol. 141, no. 4, 2013, pp. 3627-35.
Choi S, Choi Y, Choi Y, et al. Piperine reverses high fat diet-induced hepatic steatosis and insulin resistance in mice. Food Chem. 2013;141(4):3627-35.
Choi, S., Choi, Y., Choi, Y., Kim, S., Jang, J., & Park, T. (2013). Piperine reverses high fat diet-induced hepatic steatosis and insulin resistance in mice. Food Chemistry, 141(4), pp. 3627-35. doi:10.1016/j.foodchem.2013.06.028.
Choi S, et al. Piperine Reverses High Fat Diet-induced Hepatic Steatosis and Insulin Resistance in Mice. Food Chem. 2013 Dec 15;141(4):3627-35. PubMed PMID: 23993530.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Piperine reverses high fat diet-induced hepatic steatosis and insulin resistance in mice. AU - Choi,Seoyoon, AU - Choi,Youngshim, AU - Choi,Yeji, AU - Kim,Sohee, AU - Jang,Jeehee, AU - Park,Taesun, Y1 - 2013/06/17/ PY - 2012/12/03/received PY - 2013/05/22/revised PY - 2013/06/06/accepted PY - 2013/9/3/entrez PY - 2013/9/3/pubmed PY - 2014/3/29/medline KW - AKT KW - ALT KW - AMP-activated protein kinase KW - AMPK KW - AST KW - AUC KW - AdipoR1 KW - AdipoR2 KW - Adiponectin-AMPK signalling KW - CD36 KW - CD36 antigen KW - CPT1 KW - FFA KW - Fatty acid oxidation KW - Fatty liver KW - G6Pase KW - GAPDH KW - GLUT2 KW - HFD KW - IRS1 KW - Insulin signalling KW - LXRα KW - Lipogenesis KW - PEPCK KW - RT-PCR KW - S6 kinase 1 KW - S6K1 KW - SREBP1c KW - aP2 KW - adipocyte protein 2 KW - adiponectin receptor-1 KW - adiponectin receptor-2 KW - alanine aminotransferase KW - area under the curve KW - aspartate aminostransferase KW - carnitine palmitoyltransferase 1 KW - free fatty acid KW - glucose transporter-2 KW - glucose-6-phosphate dehydrogenase KW - glyceraldehyde-3-phosphate dehydrogenase KW - high-fat diet KW - insulin receptor substrate-1 KW - leptin KW - lipoprotein lipase KW - liver X receptor alpha KW - phosphoenolpyruvate carboxykinase KW - protein kinase B KW - reverse transcription-polymerase chain reaction KW - sterol regulatory element binding protein-1c SP - 3627 EP - 35 JF - Food chemistry JO - Food Chem VL - 141 IS - 4 N2 - This study examined the effect of piperine on hepatic steatosis and insulin resistance induced in mice by feeding a high-fat diet (HFD) for 13 weeks and elucidated potential underlying molecular mechanisms. Administration of piperine (50 mg/kg body weight) to mice with HFD-induced hepatic steatosis resulted in a significant increase in plasma adiponectin levels. Also, elevated plasma concentrations of insulin and glucose and hepatic lipid levels induced by feeding a HFD were reversed in mice when they were administered piperine. However, piperine did not reduce body weight and other biochemical markers to an extent where they became equal to the levels found in the CD-fed mice. Piperine reversed HFD-induced down-regulation of adiponecitn-AMP-activated protein kinase (AMPK) signalling molecules which play an important role in mediating lipogenesis, fatty acid oxidation and insulin signalling in the livers of mice. The expressions of lipogenic target genes were decreased, whereas the expression of carnitine palmitoyltransferase 1 (CPT1) gene involved in fatty acid oxidation was increased in the livers of the Pin50 group. Piperine significantly decreased the phosphorylation of insulin receptor substrate-1 (IRS-1) compared with the HFD-fed mice. Administration of piperine appeared to reverse preexisting HFD-induced hepatic steatosis and insulin resistance, probably by activation of adiponectin-AMPK signalling in mice. SN - 1873-7072 UR - https://www.unboundmedicine.com/medline/citation/23993530/Piperine_reverses_high_fat_diet_induced_hepatic_steatosis_and_insulin_resistance_in_mice_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0308-8146(13)00803-0 DB - PRIME DP - Unbound Medicine ER -