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Impact of trolox, quercetin, genistein and gallic acid on the oxidative damage to myofibrillar proteins: the carbonylation pathway.
Food Chem. 2013 Dec 15; 141(4):4000-9.FC

Abstract

The carbonylation pathway involves the oxidative deamination of lysine residues to yield a carbonyl compound (α-aminoadipic semialdehyde) that can be further oxidised to α-aminoadipic acid and form Schiff bases structures. The effect of trolox and other phenolic compounds (PhC) (namely genistein, quercetin and gallic acid) on the protein carbonylation pathway occurred during the oxidation of myofibrillar proteins (MP) catalysed by a Fe(3+)/H2O2 system was studied. Trolox and PhC can exert either antioxidant or pro-oxidant capacities depending on their concentration, the oxidation conditions and the target in proteins. In general, quercetin and genistein showed an antioxidant activity towards lipid oxidation and the carbonylation pathway at different concentrations under the analysed conditions. Plausible mechanisms for the antioxidant and pro-oxidant effects of trolox and PhC on MP are discussed. Further research is needed to shed light on the effect of PhC mixtures on both lipid and protein oxidation.

Authors+Show Affiliations

Food Technology, Department of Animal Production and Food Science, University of Extremadura, 10003 Cáceres, Spain. mariana@unex.esNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23993577

Citation

Utrera, Mariana, and Mario Estévez. "Impact of Trolox, Quercetin, Genistein and Gallic Acid On the Oxidative Damage to Myofibrillar Proteins: the Carbonylation Pathway." Food Chemistry, vol. 141, no. 4, 2013, pp. 4000-9.
Utrera M, Estévez M. Impact of trolox, quercetin, genistein and gallic acid on the oxidative damage to myofibrillar proteins: the carbonylation pathway. Food Chem. 2013;141(4):4000-9.
Utrera, M., & Estévez, M. (2013). Impact of trolox, quercetin, genistein and gallic acid on the oxidative damage to myofibrillar proteins: the carbonylation pathway. Food Chemistry, 141(4), 4000-9. https://doi.org/10.1016/j.foodchem.2013.06.107
Utrera M, Estévez M. Impact of Trolox, Quercetin, Genistein and Gallic Acid On the Oxidative Damage to Myofibrillar Proteins: the Carbonylation Pathway. Food Chem. 2013 Dec 15;141(4):4000-9. PubMed PMID: 23993577.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Impact of trolox, quercetin, genistein and gallic acid on the oxidative damage to myofibrillar proteins: the carbonylation pathway. AU - Utrera,Mariana, AU - Estévez,Mario, Y1 - 2013/07/04/ PY - 2013/03/15/received PY - 2013/06/17/revised PY - 2013/06/25/accepted PY - 2013/9/3/entrez PY - 2013/9/3/pubmed PY - 2014/3/29/medline KW - Phenolic compounds KW - Schiff bases KW - TBARS KW - Trolox KW - α-Aminoadipic acid KW - α-Aminoadipic semialdehyde SP - 4000 EP - 9 JF - Food chemistry JO - Food Chem VL - 141 IS - 4 N2 - The carbonylation pathway involves the oxidative deamination of lysine residues to yield a carbonyl compound (α-aminoadipic semialdehyde) that can be further oxidised to α-aminoadipic acid and form Schiff bases structures. The effect of trolox and other phenolic compounds (PhC) (namely genistein, quercetin and gallic acid) on the protein carbonylation pathway occurred during the oxidation of myofibrillar proteins (MP) catalysed by a Fe(3+)/H2O2 system was studied. Trolox and PhC can exert either antioxidant or pro-oxidant capacities depending on their concentration, the oxidation conditions and the target in proteins. In general, quercetin and genistein showed an antioxidant activity towards lipid oxidation and the carbonylation pathway at different concentrations under the analysed conditions. Plausible mechanisms for the antioxidant and pro-oxidant effects of trolox and PhC on MP are discussed. Further research is needed to shed light on the effect of PhC mixtures on both lipid and protein oxidation. SN - 1873-7072 UR - https://www.unboundmedicine.com/medline/citation/23993577/Impact_of_trolox_quercetin_genistein_and_gallic_acid_on_the_oxidative_damage_to_myofibrillar_proteins:_the_carbonylation_pathway_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0308-8146(13)00884-4 DB - PRIME DP - Unbound Medicine ER -