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Dual trigger with combination of gonadotropin-releasing hormone agonist and human chorionic gonadotropin significantly improves the live-birth rate for normal responders in GnRH-antagonist cycles.
Fertil Steril. 2013 Nov; 100(5):1296-302.FS

Abstract

OBJECTIVE

To investigate whether dual triggering of final oocyte maturation with a combination of gonadotropin-releasing hormone (GnRH) agonist and human chorionic gonadotropin (hCG) can improve the live-birth rate for normal responders in GnRH-antagonist in vitro fertilization/intracytoplasmic sperm injection (IVF-ICSI) cycles.

DESIGN

Retrospective cohort study.

SETTING

Infertility unit of a university-affiliated medical center.

PATIENT(S)

Normal responders to controlled ovarian hyperstimulation who were undergoing IVF-ICSI with a GnRH antagonist protocol.

INTERVENTION(S)

Standard dosage of hCG trigger (6,500 IU of recombinant hCG) versus dual trigger (0.2 mg of triptorelin and 6,500 IU of recombinant hCG).

MAIN OUTCOME MEASURE(S)

Live-birth, clinical pregnancy, and implantation rates per cycle.

RESULT(S)

A total of 376 patients with 378 completed cycles with embryo transfer were enrolled (hCG trigger/control group: n = 187; dual trigger/study group: n = 191). The dual trigger group demonstrated statistically significantly higher implantation (29.6% vs. 18.4%), clinical pregnancy (50.7% vs. 40.1%), and live-birth (41.3% vs. 30.4%) rates as compared with the hCG trigger group. There was no statistically significant difference in terms of patient demographics, cycle parameters, or embryo quality.

CONCLUSION(S)

Dual trigger of final oocyte maturation with a GnRH-agonist and a standard dosage of hCG in normal responders statistically significantly improves implantation, clinical pregnancy, and live-birth rates in GnRH-antagonist IVF cycles.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, Mackay Memorial Hospital, Taipei, Taiwan; Mackay Medicine, Nursing, and Management College, Taipei, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

23993928

Citation

Lin, Ming-Huei, et al. "Dual Trigger With Combination of Gonadotropin-releasing Hormone Agonist and Human Chorionic Gonadotropin Significantly Improves the Live-birth Rate for Normal Responders in GnRH-antagonist Cycles." Fertility and Sterility, vol. 100, no. 5, 2013, pp. 1296-302.
Lin MH, Wu FS, Lee RK, et al. Dual trigger with combination of gonadotropin-releasing hormone agonist and human chorionic gonadotropin significantly improves the live-birth rate for normal responders in GnRH-antagonist cycles. Fertil Steril. 2013;100(5):1296-302.
Lin, M. H., Wu, F. S., Lee, R. K., Li, S. H., Lin, S. Y., & Hwu, Y. M. (2013). Dual trigger with combination of gonadotropin-releasing hormone agonist and human chorionic gonadotropin significantly improves the live-birth rate for normal responders in GnRH-antagonist cycles. Fertility and Sterility, 100(5), 1296-302. https://doi.org/10.1016/j.fertnstert.2013.07.1976
Lin MH, et al. Dual Trigger With Combination of Gonadotropin-releasing Hormone Agonist and Human Chorionic Gonadotropin Significantly Improves the Live-birth Rate for Normal Responders in GnRH-antagonist Cycles. Fertil Steril. 2013;100(5):1296-302. PubMed PMID: 23993928.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dual trigger with combination of gonadotropin-releasing hormone agonist and human chorionic gonadotropin significantly improves the live-birth rate for normal responders in GnRH-antagonist cycles. AU - Lin,Ming-Huei, AU - Wu,Frank Shao-Ying, AU - Lee,Robert Kuo-Kuang, AU - Li,Sheng-Hsiang, AU - Lin,Shyr-Yeu, AU - Hwu,Yuh-Ming, Y1 - 2013/08/28/ PY - 2012/12/19/received PY - 2013/07/18/revised PY - 2013/07/18/accepted PY - 2013/9/3/entrez PY - 2013/9/3/pubmed PY - 2013/12/29/medline KW - Dual trigger KW - GnRH agonist KW - GnRH antagonist KW - normal responders SP - 1296 EP - 302 JF - Fertility and sterility JO - Fertil. Steril. VL - 100 IS - 5 N2 - OBJECTIVE: To investigate whether dual triggering of final oocyte maturation with a combination of gonadotropin-releasing hormone (GnRH) agonist and human chorionic gonadotropin (hCG) can improve the live-birth rate for normal responders in GnRH-antagonist in vitro fertilization/intracytoplasmic sperm injection (IVF-ICSI) cycles. DESIGN: Retrospective cohort study. SETTING: Infertility unit of a university-affiliated medical center. PATIENT(S): Normal responders to controlled ovarian hyperstimulation who were undergoing IVF-ICSI with a GnRH antagonist protocol. INTERVENTION(S): Standard dosage of hCG trigger (6,500 IU of recombinant hCG) versus dual trigger (0.2 mg of triptorelin and 6,500 IU of recombinant hCG). MAIN OUTCOME MEASURE(S): Live-birth, clinical pregnancy, and implantation rates per cycle. RESULT(S): A total of 376 patients with 378 completed cycles with embryo transfer were enrolled (hCG trigger/control group: n = 187; dual trigger/study group: n = 191). The dual trigger group demonstrated statistically significantly higher implantation (29.6% vs. 18.4%), clinical pregnancy (50.7% vs. 40.1%), and live-birth (41.3% vs. 30.4%) rates as compared with the hCG trigger group. There was no statistically significant difference in terms of patient demographics, cycle parameters, or embryo quality. CONCLUSION(S): Dual trigger of final oocyte maturation with a GnRH-agonist and a standard dosage of hCG in normal responders statistically significantly improves implantation, clinical pregnancy, and live-birth rates in GnRH-antagonist IVF cycles. SN - 1556-5653 UR - https://www.unboundmedicine.com/medline/citation/23993928/Dual_trigger_with_combination_of_gonadotropin_releasing_hormone_agonist_and_human_chorionic_gonadotropin_significantly_improves_the_live_birth_rate_for_normal_responders_in_GnRH_antagonist_cycles_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0015-0282(13)02762-3 DB - PRIME DP - Unbound Medicine ER -