Tags

Type your tag names separated by a space and hit enter

Early life exposure to sevoflurane impairs adulthood spatial memory in the rat.
Neurotoxicology. 2013 Dec; 39:45-56.N

Abstract

Sevoflurane is a general anesthetic commonly used in the pediatric setting because it is sweet-smelling, nonflammable, fast acting and has a very short recovery time. Although recent clinical data suggest that early anesthesia exposure is associated with subsequent learning and memory problems, it is difficult to determine the exact scope of developmental neurotoxicity associated with exposure to specific anesthetics such as sevoflurane. This is largely due to inconsistencies in the literature. Thus, in the present studies we evaluated the effect of early life exposure to sevoflurane (1%, 2%, 3% or 4%) on adulthood memory impairment in Sprague-Dawley rats. Animals were exposed to different regimens of sevoflurane anesthesia on postnatal days (PNDs) 3, 7, or 14 or at 7 weeks (P7W) of age and spatial memory performance was assessed in adulthood using the Morris Water Maze (MWM). Rats exposed to sevoflurane exhibited significant memory impairment which was concentration and exposure duration dependent. Disruption of MWM performance was more severe in animals exposed on both PNDs 3 and 7 than in animals exposed on both PNDs 3 and 14. The younger the animal's age at the time of exposure, the more significant the effect on later MWM performance. Compared to the neonates, animals exposed at P7W were relatively insensitive to sevoflurane: memory was impaired in this group only after repeated exposures to low doses or single exposures to high doses. Early life exposure to sevoflurane can result in spatial memory impairments in adulthood and the shorter the interval between exposures, the greater the deficit.

Authors+Show Affiliations

State Key Laboratory of Reproductive Medicine, Department of Anesthesiology and Critical Care Medicine, Nanjing Maternity and Child Health Care Hospital, Nanjing Medical University, Nanjing, Jiangsu 210004, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23994303

Citation

Shen, Xiaofeng, et al. "Early Life Exposure to Sevoflurane Impairs Adulthood Spatial Memory in the Rat." Neurotoxicology, vol. 39, 2013, pp. 45-56.
Shen X, Liu Y, Xu S, et al. Early life exposure to sevoflurane impairs adulthood spatial memory in the rat. Neurotoxicology. 2013;39:45-56.
Shen, X., Liu, Y., Xu, S., Zhao, Q., Guo, X., Shen, R., & Wang, F. (2013). Early life exposure to sevoflurane impairs adulthood spatial memory in the rat. Neurotoxicology, 39, 45-56. https://doi.org/10.1016/j.neuro.2013.08.007
Shen X, et al. Early Life Exposure to Sevoflurane Impairs Adulthood Spatial Memory in the Rat. Neurotoxicology. 2013;39:45-56. PubMed PMID: 23994303.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Early life exposure to sevoflurane impairs adulthood spatial memory in the rat. AU - Shen,Xiaofeng, AU - Liu,Yusheng, AU - Xu,Shiqin, AU - Zhao,Qingsong, AU - Guo,Xirong, AU - Shen,Rong, AU - Wang,Fuzhou, Y1 - 2013/08/27/ PY - 2013/05/09/received PY - 2013/08/16/revised PY - 2013/08/17/accepted PY - 2013/9/3/entrez PY - 2013/9/3/pubmed PY - 2014/7/24/medline KW - AUC KW - BID KW - Inhalation anesthesia KW - MAC KW - MWM KW - Memory KW - Morris Water Maze KW - Neonate KW - Neuronal toxicity KW - P14D KW - P3D KW - P7D KW - P7W KW - Pediatrics KW - SEM KW - SID KW - Sevoflurane KW - TID KW - area under curve KW - minimum alveolar concentration KW - once a day KW - postnatal 14 days KW - postnatal 3 days KW - postnatal 7 days KW - postnatal 7 weeks KW - standard deviation KW - three times a day KW - twice a day SP - 45 EP - 56 JF - Neurotoxicology JO - Neurotoxicology VL - 39 N2 - Sevoflurane is a general anesthetic commonly used in the pediatric setting because it is sweet-smelling, nonflammable, fast acting and has a very short recovery time. Although recent clinical data suggest that early anesthesia exposure is associated with subsequent learning and memory problems, it is difficult to determine the exact scope of developmental neurotoxicity associated with exposure to specific anesthetics such as sevoflurane. This is largely due to inconsistencies in the literature. Thus, in the present studies we evaluated the effect of early life exposure to sevoflurane (1%, 2%, 3% or 4%) on adulthood memory impairment in Sprague-Dawley rats. Animals were exposed to different regimens of sevoflurane anesthesia on postnatal days (PNDs) 3, 7, or 14 or at 7 weeks (P7W) of age and spatial memory performance was assessed in adulthood using the Morris Water Maze (MWM). Rats exposed to sevoflurane exhibited significant memory impairment which was concentration and exposure duration dependent. Disruption of MWM performance was more severe in animals exposed on both PNDs 3 and 7 than in animals exposed on both PNDs 3 and 14. The younger the animal's age at the time of exposure, the more significant the effect on later MWM performance. Compared to the neonates, animals exposed at P7W were relatively insensitive to sevoflurane: memory was impaired in this group only after repeated exposures to low doses or single exposures to high doses. Early life exposure to sevoflurane can result in spatial memory impairments in adulthood and the shorter the interval between exposures, the greater the deficit. SN - 1872-9711 UR - https://www.unboundmedicine.com/medline/citation/23994303/Early_life_exposure_to_sevoflurane_impairs_adulthood_spatial_memory_in_the_rat_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0161-813X(13)00131-9 DB - PRIME DP - Unbound Medicine ER -