Tags

Type your tag names separated by a space and hit enter

Markers of oxidative stress in follicular fluid of women with endometriosis and tubal infertility undergoing IVF.
Reprod Toxicol 2013; 42:116-24RT

Abstract

Oxidative stress and trace elements in the oocytes environment is explored in endometriosis and impact on in vitro fertilization (IVF) outcome assessed. Follicular fluid was aspirated at the time of oocyte retrieval from endometriosis (n=200) and tubal infertility (n=140) and the analytes measured using spectroscopy and HPLC. Increased concentration of reactive oxygen species (ROS), nitric oxide (NO), lipid peroxidation (LPO), iron, lead, cadmium and reduced levels of total antioxidant capacity (TAC), superoxide dismutase (SOD), catalase, glutathione peroxidase (GPx), glutathione reductase (GR), vitamins A, C, E, copper, zinc and selenium was observed compared to tubal infertility. Increased ROS and NO in endometriosis and tubal infertility associated with poor oocytes and embryo quality. Increased levels of ROS, NO, LPO, cadmium and lead were observed in women who did not become pregnant compared to women who did. Intrafollicular zinc levels were higher in women with endometriosis who subsequently became pregnant following IVF.

Authors+Show Affiliations

School of Medical Science and Technology, Indian Institute of Technology, Kharagpur, West Bengal, India.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23994512

Citation

Singh, Abhay K., et al. "Markers of Oxidative Stress in Follicular Fluid of Women With Endometriosis and Tubal Infertility Undergoing IVF." Reproductive Toxicology (Elmsford, N.Y.), vol. 42, 2013, pp. 116-24.
Singh AK, Chattopadhyay R, Chakravarty B, et al. Markers of oxidative stress in follicular fluid of women with endometriosis and tubal infertility undergoing IVF. Reprod Toxicol. 2013;42:116-24.
Singh, A. K., Chattopadhyay, R., Chakravarty, B., & Chaudhury, K. (2013). Markers of oxidative stress in follicular fluid of women with endometriosis and tubal infertility undergoing IVF. Reproductive Toxicology (Elmsford, N.Y.), 42, pp. 116-24. doi:10.1016/j.reprotox.2013.08.005.
Singh AK, et al. Markers of Oxidative Stress in Follicular Fluid of Women With Endometriosis and Tubal Infertility Undergoing IVF. Reprod Toxicol. 2013;42:116-24. PubMed PMID: 23994512.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Markers of oxidative stress in follicular fluid of women with endometriosis and tubal infertility undergoing IVF. AU - Singh,Abhay K, AU - Chattopadhyay,Ratna, AU - Chakravarty,Baidyanath, AU - Chaudhury,Koel, Y1 - 2013/08/29/ PY - 2012/08/19/received PY - 2013/08/08/revised PY - 2013/08/16/accepted PY - 2013/9/3/entrez PY - 2013/9/3/pubmed PY - 2014/7/9/medline KW - Endometriosis KW - Follicular fluid KW - In vitro fertilization (IVF) KW - Oocyte quality KW - Oxidative stress KW - Pregnancy outcome KW - Trace elements SP - 116 EP - 24 JF - Reproductive toxicology (Elmsford, N.Y.) JO - Reprod. Toxicol. VL - 42 N2 - Oxidative stress and trace elements in the oocytes environment is explored in endometriosis and impact on in vitro fertilization (IVF) outcome assessed. Follicular fluid was aspirated at the time of oocyte retrieval from endometriosis (n=200) and tubal infertility (n=140) and the analytes measured using spectroscopy and HPLC. Increased concentration of reactive oxygen species (ROS), nitric oxide (NO), lipid peroxidation (LPO), iron, lead, cadmium and reduced levels of total antioxidant capacity (TAC), superoxide dismutase (SOD), catalase, glutathione peroxidase (GPx), glutathione reductase (GR), vitamins A, C, E, copper, zinc and selenium was observed compared to tubal infertility. Increased ROS and NO in endometriosis and tubal infertility associated with poor oocytes and embryo quality. Increased levels of ROS, NO, LPO, cadmium and lead were observed in women who did not become pregnant compared to women who did. Intrafollicular zinc levels were higher in women with endometriosis who subsequently became pregnant following IVF. SN - 1873-1708 UR - https://www.unboundmedicine.com/medline/citation/23994512/Markers_of_oxidative_stress_in_follicular_fluid_of_women_with_endometriosis_and_tubal_infertility_undergoing_IVF_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0890-6238(13)00342-0 DB - PRIME DP - Unbound Medicine ER -