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Associations of dietary folate, Vitamins B6 and B12 and methionine intake with risk of breast cancer among African American and European American women.
Int J Cancer 2014; 134(6):1422-35IJ

Abstract

African American (AA) women are more likely than European American (EA) women to be diagnosed with breast cancer at younger ages and to develop poor prognosis tumors. However, these racial differences are largely unexplained. Folate and other methyl-group nutrients may be related to breast carcinogenesis, but few studies have examined these associations in AA populations. We examined the associations of dietary intake of these nutrients with breast cancer risk overall, by menopausal and estrogen receptor (ER) status among 1,582 AA (749 cases) and 1,434 EA (744 cases) women using data from a case-control study, the Women's Circle of Health Study. Unconditional multivariable logistic regression models were used to compute odds ratios (ORs) and 95% confidence intervals (CIs) for the association of each nutrient and breast cancer risk. In AA women, inverse associations were observed for natural food folate intake among premenopausal women (fourth vs. first quartile: OR = 0.57, 95% CI, 0.33-1.00; p for trend = 0.06) and for ER-positive tumors (fourth vs. first quartile: OR = 0.58, 95% CI, 0.36-0.93; p for trend = 0.03), whereas in EA women, a positive association was observed for intake of synthetic folate (fourth vs. first quartile: OR = 1.53, 95% CI, 1.06-2.21; p for trend = 0.03). Our findings suggest that natural food folate intake is inversely associated with breast cancer risk and that this association may vary by race, menopausal status or ER status. The finding of an increased risk observed among EA women with the highest intake of synthetic folate from fortified foods warrants further investigation.

Authors+Show Affiliations

Department of Cancer Prevention & Control, Roswell Park Cancer Institute, Buffalo, NY.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

23996837

Citation

Gong, Zhihong, et al. "Associations of Dietary Folate, Vitamins B6 and B12 and Methionine Intake With Risk of Breast Cancer Among African American and European American Women." International Journal of Cancer, vol. 134, no. 6, 2014, pp. 1422-35.
Gong Z, Ambrosone CB, McCann SE, et al. Associations of dietary folate, Vitamins B6 and B12 and methionine intake with risk of breast cancer among African American and European American women. Int J Cancer. 2014;134(6):1422-35.
Gong, Z., Ambrosone, C. B., McCann, S. E., Zirpoli, G., Chandran, U., Hong, C. C., ... Bandera, E. V. (2014). Associations of dietary folate, Vitamins B6 and B12 and methionine intake with risk of breast cancer among African American and European American women. International Journal of Cancer, 134(6), pp. 1422-35. doi:10.1002/ijc.28466.
Gong Z, et al. Associations of Dietary Folate, Vitamins B6 and B12 and Methionine Intake With Risk of Breast Cancer Among African American and European American Women. Int J Cancer. 2014 Mar 15;134(6):1422-35. PubMed PMID: 23996837.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Associations of dietary folate, Vitamins B6 and B12 and methionine intake with risk of breast cancer among African American and European American women. AU - Gong,Zhihong, AU - Ambrosone,Christine B, AU - McCann,Susan E, AU - Zirpoli,Gary, AU - Chandran,Urmila, AU - Hong,Chi-Chen, AU - Bovbjerg,Dana H, AU - Jandorf,Lina, AU - Ciupak,Gregory, AU - Pawlish,Karen, AU - Lu,Quanjun, AU - Hwang,Helena, AU - Khoury,Thaer, AU - Wiam,Bshara, AU - Bandera,Elisa V, Y1 - 2013/09/30/ PY - 2013/05/17/received PY - 2013/08/22/accepted PY - 2013/9/3/entrez PY - 2013/9/3/pubmed PY - 2014/2/26/medline KW - African American KW - European American KW - breast cancer KW - diet KW - folate KW - one-carbon nutrients SP - 1422 EP - 35 JF - International journal of cancer JO - Int. J. Cancer VL - 134 IS - 6 N2 - African American (AA) women are more likely than European American (EA) women to be diagnosed with breast cancer at younger ages and to develop poor prognosis tumors. However, these racial differences are largely unexplained. Folate and other methyl-group nutrients may be related to breast carcinogenesis, but few studies have examined these associations in AA populations. We examined the associations of dietary intake of these nutrients with breast cancer risk overall, by menopausal and estrogen receptor (ER) status among 1,582 AA (749 cases) and 1,434 EA (744 cases) women using data from a case-control study, the Women's Circle of Health Study. Unconditional multivariable logistic regression models were used to compute odds ratios (ORs) and 95% confidence intervals (CIs) for the association of each nutrient and breast cancer risk. In AA women, inverse associations were observed for natural food folate intake among premenopausal women (fourth vs. first quartile: OR = 0.57, 95% CI, 0.33-1.00; p for trend = 0.06) and for ER-positive tumors (fourth vs. first quartile: OR = 0.58, 95% CI, 0.36-0.93; p for trend = 0.03), whereas in EA women, a positive association was observed for intake of synthetic folate (fourth vs. first quartile: OR = 1.53, 95% CI, 1.06-2.21; p for trend = 0.03). Our findings suggest that natural food folate intake is inversely associated with breast cancer risk and that this association may vary by race, menopausal status or ER status. The finding of an increased risk observed among EA women with the highest intake of synthetic folate from fortified foods warrants further investigation. SN - 1097-0215 UR - https://www.unboundmedicine.com/medline/citation/23996837/Associations_of_dietary_folate_Vitamins_B6_and_B12_and_methionine_intake_with_risk_of_breast_cancer_among_African_American_and_European_American_women_ L2 - https://doi.org/10.1002/ijc.28466 DB - PRIME DP - Unbound Medicine ER -