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ACE2-Ang-(1-7)-Mas Axis in Brain: A Potential Target for Prevention and Treatment of Ischemic Stroke.
Curr Neuropharmacol. 2013 Mar; 11(2):209-17.CN

Abstract

The renin-angiotensin system (RAS) in brain is a crucial regulator for physiological homeostasis and diseases of cerebrovascular system, such as ischemic stroke. Overactivation of brain Angiotensin-converting enzyme (ACE) - Angiotensin II (Ang II) - Angiotensin II type 1 receptor (AT1R) axis was found to be involved in the progress of hypertension, atherosclerosis and thrombogenesis, which increased the susceptibility to ischemic stroke. Besides, brain Ang II levels have been revealed to be increased in ischemic tissues after stroke, and contribute to neural damage through elevating oxidative stress levels and inducing inflammatory response in the ischemic hemisphere via AT1R. In recent years, new components of RAS have been discovered, including ACE2, Angiotensin-(1-7) [Ang-(1-7)] and Mas, which constitute ACE2-Ang-(1-7)-Mas axis. ACE2 converts Ang II to Ang-(1-7), and Ang-(1-7) binds with its receptor Mas, exerting benefical effects in cerebrovascular disease. Through interacting with nitric oxide and bradykinin, Ang-(1-7) could attenuate the development of hypertension and the pathologic progress of atherosclerosis. Besides, its antithrombotic activity also prevents thrombogenic events, which may contribute to reduce the risk of ischemic stroke. In addition, after ischemia insult, ACE2-Ang-(1-7)-Mas has been shown to reduce the cerebral infarct size and improve neurological deficits through its antioxidative and anti-inflammatory effects. Taken together, activation of the ACE2-Ang-(1-7)-Mas axis may become a novel therapeutic target in prevention and treatment of ischemia stroke, which deserves further investigations.

Authors+Show Affiliations

Department of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing, P.R. China.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23997755

Citation

Jiang, Teng, et al. "ACE2-Ang-(1-7)-Mas Axis in Brain: a Potential Target for Prevention and Treatment of Ischemic Stroke." Current Neuropharmacology, vol. 11, no. 2, 2013, pp. 209-17.
Jiang T, Gao L, Lu J, et al. ACE2-Ang-(1-7)-Mas Axis in Brain: A Potential Target for Prevention and Treatment of Ischemic Stroke. Curr Neuropharmacol. 2013;11(2):209-17.
Jiang, T., Gao, L., Lu, J., & Zhang, Y. D. (2013). ACE2-Ang-(1-7)-Mas Axis in Brain: A Potential Target for Prevention and Treatment of Ischemic Stroke. Current Neuropharmacology, 11(2), 209-17. https://doi.org/10.2174/1570159X11311020007
Jiang T, et al. ACE2-Ang-(1-7)-Mas Axis in Brain: a Potential Target for Prevention and Treatment of Ischemic Stroke. Curr Neuropharmacol. 2013;11(2):209-17. PubMed PMID: 23997755.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - ACE2-Ang-(1-7)-Mas Axis in Brain: A Potential Target for Prevention and Treatment of Ischemic Stroke. AU - Jiang,Teng, AU - Gao,Li, AU - Lu,Jie, AU - Zhang,Ying-Dong, PY - 2012/07/08/received PY - 2012/09/12/revised PY - 2012/10/08/accepted PY - 2013/9/3/entrez PY - 2013/9/3/pubmed PY - 2013/9/3/medline KW - Angiotensin-(1-7) KW - Neuroprotection KW - Oxidative stress. KW - Renin-angiotensin system KW - Stroke SP - 209 EP - 17 JF - Current neuropharmacology JO - Curr Neuropharmacol VL - 11 IS - 2 N2 - The renin-angiotensin system (RAS) in brain is a crucial regulator for physiological homeostasis and diseases of cerebrovascular system, such as ischemic stroke. Overactivation of brain Angiotensin-converting enzyme (ACE) - Angiotensin II (Ang II) - Angiotensin II type 1 receptor (AT1R) axis was found to be involved in the progress of hypertension, atherosclerosis and thrombogenesis, which increased the susceptibility to ischemic stroke. Besides, brain Ang II levels have been revealed to be increased in ischemic tissues after stroke, and contribute to neural damage through elevating oxidative stress levels and inducing inflammatory response in the ischemic hemisphere via AT1R. In recent years, new components of RAS have been discovered, including ACE2, Angiotensin-(1-7) [Ang-(1-7)] and Mas, which constitute ACE2-Ang-(1-7)-Mas axis. ACE2 converts Ang II to Ang-(1-7), and Ang-(1-7) binds with its receptor Mas, exerting benefical effects in cerebrovascular disease. Through interacting with nitric oxide and bradykinin, Ang-(1-7) could attenuate the development of hypertension and the pathologic progress of atherosclerosis. Besides, its antithrombotic activity also prevents thrombogenic events, which may contribute to reduce the risk of ischemic stroke. In addition, after ischemia insult, ACE2-Ang-(1-7)-Mas has been shown to reduce the cerebral infarct size and improve neurological deficits through its antioxidative and anti-inflammatory effects. Taken together, activation of the ACE2-Ang-(1-7)-Mas axis may become a novel therapeutic target in prevention and treatment of ischemia stroke, which deserves further investigations. SN - 1570-159X UR - https://www.unboundmedicine.com/medline/citation/23997755/ACE2_Ang__1_7__Mas_Axis_in_Brain:_A_Potential_Target_for_Prevention_and_Treatment_of_Ischemic_Stroke_ L2 - https://www.ingentaconnect.com/openurl?genre=article&issn=1570-159X&volume=11&issue=2&spage=209&aulast=Jiang DB - PRIME DP - Unbound Medicine ER -
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