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Association between metabolic syndrome and chronic kidney disease in perimenopausal women.
Int J Environ Res Public Health 2013; 10(9):3987-97IJ

Abstract

The purpose of the study was to explore the association between metabolic syndrome (MetS) and chronic kidney disease (CKD) in perimenopausal women. A cross-sectional study was conducted in Zhuhai from June to October 2012. Perimenopausal women (n = 685) were included in the study. All participants were divided into three subgroups: Group 1, 40 years old ≤ Age < 50 years old; Group 2, 50 years old ≤ Age < 60 years old; Group 3, 60 years old ≤ Age ≤ 65 years old. MetS was associated with CKD (p < 0.01) in the unadjusted analyses in total subjects. After adjusting the potential confounders, the odd ratios of CKD for MetS was 2.66 (95% CI 1.56 to 4.49, p < 0.001). There was no relationship between MetS and CKD in both Group 1 and Group 3. MetS was associated with CKD (p < 0.001) in the unadjusted analyses in Group 2. After adjusting for potential confounders, MetS was significantly associated with CKD. The odd ratios for MetS was 6.79 (95% CI 2.30 to 20.09, p < 0.001). There was no relationship between elevated blood pressure, elevated fasting glucose, abdominal obesity, Low HDL cholesterol, elevated triglycerides and CKD in both Group 1 and Group 3. Elevated blood pressure was associated with CKD in Group 2 (unadjusted Odds ratio: 4.52 (1.28-16.02), p = 0.02). After adjusting for potential confounders, there was no relationship between elevated blood pressure and CKD (p = 0.78). Elevated fasting glucose was associated with CKD in Group 2 (unadjusted Odds ratio: 3.69 (1.10-12.38), p = 0.03). After adjusting for potential confounders, there was no relationship between elevated fasting glucose and CKD (p = 0.15). There was no relationship between abdominal obesity, Low HDL cholesterol, elevated triglycerides and CKD in Group 2. These findings suggest that in perimenopausal women aged from 50 or older to 60 MetS was associated with CKD. There is no relationship between MetS and CKD in perimenopausal women aged from 40 or older to 50 and aged from 60 or older to 65.

Authors+Show Affiliations

Department of Nephronology, Institute of Nephronology and Urology, The Third Affiliated Hospital of Southern Medical University, Guangzhou 510630, China. liyongqiang851@163.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23999547

Citation

Li, Yongqiang, et al. "Association Between Metabolic Syndrome and Chronic Kidney Disease in Perimenopausal Women." International Journal of Environmental Research and Public Health, vol. 10, no. 9, 2013, pp. 3987-97.
Li Y, Zhao L, Chen Y, et al. Association between metabolic syndrome and chronic kidney disease in perimenopausal women. Int J Environ Res Public Health. 2013;10(9):3987-97.
Li, Y., Zhao, L., Chen, Y., Liu, A., Liu, X., Shao, X., ... Zou, H. (2013). Association between metabolic syndrome and chronic kidney disease in perimenopausal women. International Journal of Environmental Research and Public Health, 10(9), pp. 3987-97. doi:10.3390/ijerph10093987.
Li Y, et al. Association Between Metabolic Syndrome and Chronic Kidney Disease in Perimenopausal Women. Int J Environ Res Public Health. 2013 Aug 30;10(9):3987-97. PubMed PMID: 23999547.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association between metabolic syndrome and chronic kidney disease in perimenopausal women. AU - Li,Yongqiang, AU - Zhao,Liqin, AU - Chen,Youming, AU - Liu,Aiqun, AU - Liu,Xinyu, AU - Shao,Xiaofei, AU - Zhang,Ying, AU - Wang,Honglei, AU - Wang,Xiaohong, AU - Li,Bin, AU - Deng,Kangping, AU - Liu,Qin, AU - Holthöfer,Harry, AU - Zou,Hequn, Y1 - 2013/08/30/ PY - 2013/07/09/received PY - 2013/08/20/revised PY - 2013/08/22/accepted PY - 2013/9/4/entrez PY - 2013/9/4/pubmed PY - 2014/3/26/medline SP - 3987 EP - 97 JF - International journal of environmental research and public health JO - Int J Environ Res Public Health VL - 10 IS - 9 N2 - The purpose of the study was to explore the association between metabolic syndrome (MetS) and chronic kidney disease (CKD) in perimenopausal women. A cross-sectional study was conducted in Zhuhai from June to October 2012. Perimenopausal women (n = 685) were included in the study. All participants were divided into three subgroups: Group 1, 40 years old ≤ Age < 50 years old; Group 2, 50 years old ≤ Age < 60 years old; Group 3, 60 years old ≤ Age ≤ 65 years old. MetS was associated with CKD (p < 0.01) in the unadjusted analyses in total subjects. After adjusting the potential confounders, the odd ratios of CKD for MetS was 2.66 (95% CI 1.56 to 4.49, p < 0.001). There was no relationship between MetS and CKD in both Group 1 and Group 3. MetS was associated with CKD (p < 0.001) in the unadjusted analyses in Group 2. After adjusting for potential confounders, MetS was significantly associated with CKD. The odd ratios for MetS was 6.79 (95% CI 2.30 to 20.09, p < 0.001). There was no relationship between elevated blood pressure, elevated fasting glucose, abdominal obesity, Low HDL cholesterol, elevated triglycerides and CKD in both Group 1 and Group 3. Elevated blood pressure was associated with CKD in Group 2 (unadjusted Odds ratio: 4.52 (1.28-16.02), p = 0.02). After adjusting for potential confounders, there was no relationship between elevated blood pressure and CKD (p = 0.78). Elevated fasting glucose was associated with CKD in Group 2 (unadjusted Odds ratio: 3.69 (1.10-12.38), p = 0.03). After adjusting for potential confounders, there was no relationship between elevated fasting glucose and CKD (p = 0.15). There was no relationship between abdominal obesity, Low HDL cholesterol, elevated triglycerides and CKD in Group 2. These findings suggest that in perimenopausal women aged from 50 or older to 60 MetS was associated with CKD. There is no relationship between MetS and CKD in perimenopausal women aged from 40 or older to 50 and aged from 60 or older to 65. SN - 1660-4601 UR - https://www.unboundmedicine.com/medline/citation/23999547/Association_between_metabolic_syndrome_and_chronic_kidney_disease_in_perimenopausal_women_ L2 - http://www.mdpi.com/resolver?pii=ijerph10093987 DB - PRIME DP - Unbound Medicine ER -