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Cytomegalovirus seropositivity is negatively associated with multiple sclerosis.

Abstract

BACKGROUND

Epidemiological data suggest a role for common viruses in the pathogenesis of multiple sclerosis (MS), and recent data showed a negative association of past cytomegalovirus (CMV) infection on pediatric MS risk.

OBJECTIVE

Our aim was to analyze the association of CMV infection with MS risk in an adult case-control material. A meta-analysis was performed to validate our findings.

METHODS

Epidemiological Investigation in MS (EIMS) is a case-control study with incident cases and population-based controls. Anti-CMV antibody titers were measured with ELISA, and HLA-A and DRB1 genotyping was performed with SSP-PCR, in 658 MS cases, who all fulfilled the McDonald criteria for MS, and 786 controls.

RESULTS

CMV seropositivity was associated with a decreased MS risk, OR = 0.73 (0.58-0.92 95% CI), p = 0.005, adjusted for index age, gender, smoking, sun exposure, EBNA1 IgG titer and HLA-A*02 and DRB1*15. When we removed all cases and controls younger than 18 years at index, the protective effect was still apparent.

CONCLUSIONS

CMV is negatively associated with adult-onset MS pathology, consistent with results from a study on pediatric MS cases. It remains to be shown whether this negative association is due to a true protective effect of CMV infection on MS risk.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Clinical Neuroscience, Karolinska Institutet, Karolinska University Hospital Solna, Sweden.

    , , , , , , ,

    Source

    MeSH

    Adolescent
    Adult
    Aged
    Cytomegalovirus Infections
    Female
    Humans
    Male
    Middle Aged
    Multiple Sclerosis
    Young Adult

    Pub Type(s)

    Journal Article
    Meta-Analysis
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    23999606

    Citation

    Sundqvist, E, et al. "Cytomegalovirus Seropositivity Is Negatively Associated With Multiple Sclerosis." Multiple Sclerosis (Houndmills, Basingstoke, England), vol. 20, no. 2, 2014, pp. 165-73.
    Sundqvist E, Bergström T, Daialhosein H, et al. Cytomegalovirus seropositivity is negatively associated with multiple sclerosis. Mult Scler. 2014;20(2):165-73.
    Sundqvist, E., Bergström, T., Daialhosein, H., Nyström, M., Sundström, P., Hillert, J., ... Olsson, T. (2014). Cytomegalovirus seropositivity is negatively associated with multiple sclerosis. Multiple Sclerosis (Houndmills, Basingstoke, England), 20(2), pp. 165-73. doi:10.1177/1352458513494489.
    Sundqvist E, et al. Cytomegalovirus Seropositivity Is Negatively Associated With Multiple Sclerosis. Mult Scler. 2014;20(2):165-73. PubMed PMID: 23999606.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Cytomegalovirus seropositivity is negatively associated with multiple sclerosis. AU - Sundqvist,E, AU - Bergström,T, AU - Daialhosein,H, AU - Nyström,M, AU - Sundström,P, AU - Hillert,J, AU - Alfredsson,L, AU - Kockum,I, AU - Olsson,T, Y1 - 2013/09/02/ PY - 2013/9/4/entrez PY - 2013/9/4/pubmed PY - 2014/9/25/medline KW - Multiple sclerosis KW - case-control study KW - cytomegalovirus KW - environmental factors KW - viral infections SP - 165 EP - 73 JF - Multiple sclerosis (Houndmills, Basingstoke, England) JO - Mult. Scler. VL - 20 IS - 2 N2 - BACKGROUND: Epidemiological data suggest a role for common viruses in the pathogenesis of multiple sclerosis (MS), and recent data showed a negative association of past cytomegalovirus (CMV) infection on pediatric MS risk. OBJECTIVE: Our aim was to analyze the association of CMV infection with MS risk in an adult case-control material. A meta-analysis was performed to validate our findings. METHODS: Epidemiological Investigation in MS (EIMS) is a case-control study with incident cases and population-based controls. Anti-CMV antibody titers were measured with ELISA, and HLA-A and DRB1 genotyping was performed with SSP-PCR, in 658 MS cases, who all fulfilled the McDonald criteria for MS, and 786 controls. RESULTS: CMV seropositivity was associated with a decreased MS risk, OR = 0.73 (0.58-0.92 95% CI), p = 0.005, adjusted for index age, gender, smoking, sun exposure, EBNA1 IgG titer and HLA-A*02 and DRB1*15. When we removed all cases and controls younger than 18 years at index, the protective effect was still apparent. CONCLUSIONS: CMV is negatively associated with adult-onset MS pathology, consistent with results from a study on pediatric MS cases. It remains to be shown whether this negative association is due to a true protective effect of CMV infection on MS risk. SN - 1477-0970 UR - https://www.unboundmedicine.com/medline/citation/23999606/full_citation L2 - http://journals.sagepub.com/doi/full/10.1177/1352458513494489?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -