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Cytomegalovirus seropositivity is negatively associated with multiple sclerosis.
Mult Scler 2014; 20(2):165-73MS

Abstract

BACKGROUND

Epidemiological data suggest a role for common viruses in the pathogenesis of multiple sclerosis (MS), and recent data showed a negative association of past cytomegalovirus (CMV) infection on pediatric MS risk.

OBJECTIVE

Our aim was to analyze the association of CMV infection with MS risk in an adult case-control material. A meta-analysis was performed to validate our findings.

METHODS

Epidemiological Investigation in MS (EIMS) is a case-control study with incident cases and population-based controls. Anti-CMV antibody titers were measured with ELISA, and HLA-A and DRB1 genotyping was performed with SSP-PCR, in 658 MS cases, who all fulfilled the McDonald criteria for MS, and 786 controls.

RESULTS

CMV seropositivity was associated with a decreased MS risk, OR = 0.73 (0.58-0.92 95% CI), p = 0.005, adjusted for index age, gender, smoking, sun exposure, EBNA1 IgG titer and HLA-A*02 and DRB1*15. When we removed all cases and controls younger than 18 years at index, the protective effect was still apparent.

CONCLUSIONS

CMV is negatively associated with adult-onset MS pathology, consistent with results from a study on pediatric MS cases. It remains to be shown whether this negative association is due to a true protective effect of CMV infection on MS risk.

Authors+Show Affiliations

Department of Clinical Neuroscience, Karolinska Institutet, Karolinska University Hospital Solna, Sweden.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23999606

Citation

Sundqvist, E, et al. "Cytomegalovirus Seropositivity Is Negatively Associated With Multiple Sclerosis." Multiple Sclerosis (Houndmills, Basingstoke, England), vol. 20, no. 2, 2014, pp. 165-73.
Sundqvist E, Bergström T, Daialhosein H, et al. Cytomegalovirus seropositivity is negatively associated with multiple sclerosis. Mult Scler. 2014;20(2):165-73.
Sundqvist, E., Bergström, T., Daialhosein, H., Nyström, M., Sundström, P., Hillert, J., ... Olsson, T. (2014). Cytomegalovirus seropositivity is negatively associated with multiple sclerosis. Multiple Sclerosis (Houndmills, Basingstoke, England), 20(2), pp. 165-73. doi:10.1177/1352458513494489.
Sundqvist E, et al. Cytomegalovirus Seropositivity Is Negatively Associated With Multiple Sclerosis. Mult Scler. 2014;20(2):165-73. PubMed PMID: 23999606.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cytomegalovirus seropositivity is negatively associated with multiple sclerosis. AU - Sundqvist,E, AU - Bergström,T, AU - Daialhosein,H, AU - Nyström,M, AU - Sundström,P, AU - Hillert,J, AU - Alfredsson,L, AU - Kockum,I, AU - Olsson,T, Y1 - 2013/09/02/ PY - 2013/9/4/entrez PY - 2013/9/4/pubmed PY - 2014/9/25/medline KW - Multiple sclerosis KW - case-control study KW - cytomegalovirus KW - environmental factors KW - viral infections SP - 165 EP - 73 JF - Multiple sclerosis (Houndmills, Basingstoke, England) JO - Mult. Scler. VL - 20 IS - 2 N2 - BACKGROUND: Epidemiological data suggest a role for common viruses in the pathogenesis of multiple sclerosis (MS), and recent data showed a negative association of past cytomegalovirus (CMV) infection on pediatric MS risk. OBJECTIVE: Our aim was to analyze the association of CMV infection with MS risk in an adult case-control material. A meta-analysis was performed to validate our findings. METHODS: Epidemiological Investigation in MS (EIMS) is a case-control study with incident cases and population-based controls. Anti-CMV antibody titers were measured with ELISA, and HLA-A and DRB1 genotyping was performed with SSP-PCR, in 658 MS cases, who all fulfilled the McDonald criteria for MS, and 786 controls. RESULTS: CMV seropositivity was associated with a decreased MS risk, OR = 0.73 (0.58-0.92 95% CI), p = 0.005, adjusted for index age, gender, smoking, sun exposure, EBNA1 IgG titer and HLA-A*02 and DRB1*15. When we removed all cases and controls younger than 18 years at index, the protective effect was still apparent. CONCLUSIONS: CMV is negatively associated with adult-onset MS pathology, consistent with results from a study on pediatric MS cases. It remains to be shown whether this negative association is due to a true protective effect of CMV infection on MS risk. SN - 1477-0970 UR - https://www.unboundmedicine.com/medline/citation/23999606/full_citation L2 - http://journals.sagepub.com/doi/full/10.1177/1352458513494489?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -