Tags

Type your tag names separated by a space and hit enter

Association of body mass index with risk of luminal A but not luminal B estrogen receptor-positive and HER2-negative breast cancer for postmenopausal Japanese women.
Breast Cancer 2015; 22(4):399-405BC

Abstract

BACKGROUND

The impact of body mass index (BMI) on the risk of postmenopausal estrogen receptor (ER)-positive breast cancers has been well documented. However, the mechanism for the impact of BMI on the etiology of luminal A and luminal B subtypes has not yet been identified.

METHODS

We analyzed associations between BMI and breast cancers stratified by immunohistochemically defined intrinsic subtypes, and 1,297 Japanese women (615 breast cancer patients and 682 healthy women from a breast cancer screening program) were enrolled in a case-control study. ER-positive/human epidermal growth factor receptor 2 (HER2)-negative breast cancers were classified into luminal A and B subtypes according to Ki67 expression levels.

RESULTS

Higher BMI was significantly positively associated with postmenopausal breast cancer risk for one-unit increase in BMI (adjusted odds ratio (aOR) 1.09, 95 % confidence interval (CI) 1.04-1.15; P = 0.0008). Analyses of postmenopausal women revealed that BMI was consistently and exclusively associated with luminal A incidence (aOR 1.18, 95 % CI 1.10-1.26; P < 0.0001). When BMI was divided into three categories corresponding to those of controls, among postmenopausal women, the observed positive association was confined to luminal A (high vs low, aOR 2.98, 95 % CI 1.53-5.80; P < 0.005), but not luminal B (aOR 0.95, 95 % CI 0.47-1.91) subtypes.

CONCLUSIONS

We observed that BMI was significantly positively associated with increased risk of postmenopausal breast cancer for Japanese women with luminal A, but not with luminal B tumor subtype.

Authors+Show Affiliations

Division of Breast and Endocrine, Department of Surgery, Hyogo College of Medicine, Mukogawa-cho 1-1, Nishinomiya, Hyogo, 663-8501, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Study
Journal Article

Language

eng

PubMed ID

24000037

Citation

Miyagawa, Yoshimasa, et al. "Association of Body Mass Index With Risk of Luminal a but Not Luminal B Estrogen Receptor-positive and HER2-negative Breast Cancer for Postmenopausal Japanese Women." Breast Cancer (Tokyo, Japan), vol. 22, no. 4, 2015, pp. 399-405.
Miyagawa Y, Miyake T, Yanai A, et al. Association of body mass index with risk of luminal A but not luminal B estrogen receptor-positive and HER2-negative breast cancer for postmenopausal Japanese women. Breast Cancer. 2015;22(4):399-405.
Miyagawa, Y., Miyake, T., Yanai, A., Murase, K., Imamura, M., Ichii, S., ... Miyoshi, Y. (2015). Association of body mass index with risk of luminal A but not luminal B estrogen receptor-positive and HER2-negative breast cancer for postmenopausal Japanese women. Breast Cancer (Tokyo, Japan), 22(4), pp. 399-405. doi:10.1007/s12282-013-0493-z.
Miyagawa Y, et al. Association of Body Mass Index With Risk of Luminal a but Not Luminal B Estrogen Receptor-positive and HER2-negative Breast Cancer for Postmenopausal Japanese Women. Breast Cancer. 2015;22(4):399-405. PubMed PMID: 24000037.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of body mass index with risk of luminal A but not luminal B estrogen receptor-positive and HER2-negative breast cancer for postmenopausal Japanese women. AU - Miyagawa,Yoshimasa, AU - Miyake,Tomohiro, AU - Yanai,Ayako, AU - Murase,Keiko, AU - Imamura,Michiko, AU - Ichii,Shigetoshi, AU - Takatsuka,Yuichi, AU - Ito,Takashi, AU - Hirota,Seiichi, AU - Saito,Masaru, AU - Kotoura,Yoshinao, AU - Miyauchi,Keisuke, AU - Fujimoto,Yasuhisa, AU - Hatada,Takuya, AU - Sasa,Mitsunori, AU - Miyoshi,Yasuo, Y1 - 2013/09/03/ PY - 2013/05/20/received PY - 2013/08/22/accepted PY - 2013/9/4/entrez PY - 2013/9/4/pubmed PY - 2016/4/26/medline SP - 399 EP - 405 JF - Breast cancer (Tokyo, Japan) JO - Breast Cancer VL - 22 IS - 4 N2 - BACKGROUND: The impact of body mass index (BMI) on the risk of postmenopausal estrogen receptor (ER)-positive breast cancers has been well documented. However, the mechanism for the impact of BMI on the etiology of luminal A and luminal B subtypes has not yet been identified. METHODS: We analyzed associations between BMI and breast cancers stratified by immunohistochemically defined intrinsic subtypes, and 1,297 Japanese women (615 breast cancer patients and 682 healthy women from a breast cancer screening program) were enrolled in a case-control study. ER-positive/human epidermal growth factor receptor 2 (HER2)-negative breast cancers were classified into luminal A and B subtypes according to Ki67 expression levels. RESULTS: Higher BMI was significantly positively associated with postmenopausal breast cancer risk for one-unit increase in BMI (adjusted odds ratio (aOR) 1.09, 95 % confidence interval (CI) 1.04-1.15; P = 0.0008). Analyses of postmenopausal women revealed that BMI was consistently and exclusively associated with luminal A incidence (aOR 1.18, 95 % CI 1.10-1.26; P < 0.0001). When BMI was divided into three categories corresponding to those of controls, among postmenopausal women, the observed positive association was confined to luminal A (high vs low, aOR 2.98, 95 % CI 1.53-5.80; P < 0.005), but not luminal B (aOR 0.95, 95 % CI 0.47-1.91) subtypes. CONCLUSIONS: We observed that BMI was significantly positively associated with increased risk of postmenopausal breast cancer for Japanese women with luminal A, but not with luminal B tumor subtype. SN - 1880-4233 UR - https://www.unboundmedicine.com/medline/citation/24000037/Association_of_body_mass_index_with_risk_of_luminal_A_but_not_luminal_B_estrogen_receptor_positive_and_HER2_negative_breast_cancer_for_postmenopausal_Japanese_women_ L2 - https://dx.doi.org/10.1007/s12282-013-0493-z DB - PRIME DP - Unbound Medicine ER -