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Hyperandrogenemia association with acne and hirsutism severity in Croatian women with polycystic ovary syndrome.
Acta Dermatovenerol Croat. 2013; 21(2):105-12.AD

Abstract

Clinical traits associated with androgen, acne and hirsutism, are important diagnostic features of polycystic ovary syndrome (PCOS). As androgens are necessary for the development of cutaneous signs of PCOS, patients with severe forms of clinical hyperandrogenism are expected to present with higher levels of plasma androgens. This relationship has not been well established and studies examining the relationship have produced inconsistent results. The aim of this study was to analyze the correlation between the severity of clinical traits caused by androgen, acne and hirsutism, with plasma levels of androgens in Croatian women diagnosed with PCOS. One hundred and forty-five women of reproductive age with isolated acne (n=61) or isolated hirsutism (n=84), oligo/amenorrhea and polycystic morphology of the ovaries were enrolled in the study. Acne grade, hirsutism grade, body mass index (BMI) and waist to hip ratio (WHR) were recorded. Hormonal profiles were measured and assessment of insulin resistance was performed. There were no significant associations between acne severity and BMI, WHR and examined hormonal and insulin resistance parameters. There was a significant correlation between sex-hormone binding globulin (SHBG) and free testosterone levels and the severity of hirsutism (ρ=-0.611, P<0.001 and ρ=0.337, P=0.002, respectively). No significant association was found between the hirsutism grade and other hormonal and metabolic parameters examined. In conclusion, acne severity in PCOS patients is not linearly associated with serum androgen levels; therefore, their levels should not be used to determine the dose of anti-androgen therapy. The observed negative correlation between serum SHBG levels and the degree of hirsutism suggests that hormonal contraception, which elevates SHBG, should be used as primary therapy in hirsute PCOS patients.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, University Hospital Center Zagreb, Petrova 13, HR-10000 Zagreb, Croatia.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

24001418

Citation

Pavičić Baldani, Dinka, et al. "Hyperandrogenemia Association With Acne and Hirsutism Severity in Croatian Women With Polycystic Ovary Syndrome." Acta Dermatovenerologica Croatica : ADC, vol. 21, no. 2, 2013, pp. 105-12.
Pavičić Baldani D, Škrgatić L, Bukvić Mokos Z, et al. Hyperandrogenemia association with acne and hirsutism severity in Croatian women with polycystic ovary syndrome. Acta Dermatovenerol Croat. 2013;21(2):105-12.
Pavičić Baldani, D., Škrgatić, L., Bukvić Mokos, Z., & Trgovčić, I. (2013). Hyperandrogenemia association with acne and hirsutism severity in Croatian women with polycystic ovary syndrome. Acta Dermatovenerologica Croatica : ADC, 21(2), 105-12.
Pavičić Baldani D, et al. Hyperandrogenemia Association With Acne and Hirsutism Severity in Croatian Women With Polycystic Ovary Syndrome. Acta Dermatovenerol Croat. 2013;21(2):105-12. PubMed PMID: 24001418.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hyperandrogenemia association with acne and hirsutism severity in Croatian women with polycystic ovary syndrome. AU - Pavičić Baldani,Dinka, AU - Škrgatić,Lana, AU - Bukvić Mokos,Zrinka, AU - Trgovčić,Iva, PY - 2013/9/5/entrez PY - 2013/9/5/pubmed PY - 2014/6/11/medline SP - 105 EP - 12 JF - Acta dermatovenerologica Croatica : ADC JO - Acta Dermatovenerol Croat VL - 21 IS - 2 N2 - Clinical traits associated with androgen, acne and hirsutism, are important diagnostic features of polycystic ovary syndrome (PCOS). As androgens are necessary for the development of cutaneous signs of PCOS, patients with severe forms of clinical hyperandrogenism are expected to present with higher levels of plasma androgens. This relationship has not been well established and studies examining the relationship have produced inconsistent results. The aim of this study was to analyze the correlation between the severity of clinical traits caused by androgen, acne and hirsutism, with plasma levels of androgens in Croatian women diagnosed with PCOS. One hundred and forty-five women of reproductive age with isolated acne (n=61) or isolated hirsutism (n=84), oligo/amenorrhea and polycystic morphology of the ovaries were enrolled in the study. Acne grade, hirsutism grade, body mass index (BMI) and waist to hip ratio (WHR) were recorded. Hormonal profiles were measured and assessment of insulin resistance was performed. There were no significant associations between acne severity and BMI, WHR and examined hormonal and insulin resistance parameters. There was a significant correlation between sex-hormone binding globulin (SHBG) and free testosterone levels and the severity of hirsutism (ρ=-0.611, P<0.001 and ρ=0.337, P=0.002, respectively). No significant association was found between the hirsutism grade and other hormonal and metabolic parameters examined. In conclusion, acne severity in PCOS patients is not linearly associated with serum androgen levels; therefore, their levels should not be used to determine the dose of anti-androgen therapy. The observed negative correlation between serum SHBG levels and the degree of hirsutism suggests that hormonal contraception, which elevates SHBG, should be used as primary therapy in hirsute PCOS patients. SN - 1847-6538 UR - https://www.unboundmedicine.com/medline/citation/24001418/Hyperandrogenemia_association_with_acne_and_hirsutism_severity_in_Croatian_women_with_polycystic_ovary_syndrome_ DB - PRIME DP - Unbound Medicine ER -