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Plasma 25-hydroxyvitamin D and its genetic determinants in relation to incident type 2 diabetes: a prospective case-cohort study.
Eur J Epidemiol. 2013 Sep; 28(9):743-52.EJ

Abstract

It is unclear whether vitamin D lowers risk of type 2 diabetes (T2D). In an observational study, we assessed the prospective association between plasma 25-hydroxyvitamin D (25(OH)D) and incident T2D, and evaluated whether it holds up for genetically determined elevated 25(OH)D. We used a case-cohort study nested within the German arm of the European Prospective Investigation into Cancer. From a total cohort of 53,088 participants with a mean follow-up of 6.6 years, we identified a random subcohort of 2,121 participants (57% women) and 1,572 incident cases of T2D. 25(OH)D was measured in baseline plasma samples retrieved from frozen storage. Mean plasma 25(OH)D in the subcohort was 47.1 (5th-95th percentile 19.6-80.7) nmol/L. After controlling for age, sex, center, season of blood draw, education, and lifestyle, the hazard of T2D decreased across increasing plasma concentrations of 25(OH)D (P linear trend<0.0001). The association became non-linear after adjustment for BMI and waist circumference (P non-linearity<0.0001), with the inverse association being restricted to participants with 25(OH)D concentrations below ~45 nmol/L (hazard ratio per 5 nmol/L higher 25(OH)D 0.91, 95% CI 0.84-0.98). A score predicting genetically determined plasma 25(OH)D by weighting four independent single-nucleotide polymorphisms by their effect on 25(OH)D, explained 3.7% of the variance in 25(OH)D. The hazard ratio (95% CI) per 5 nmol/L higher genetically predicted 25(OH)D was 0.98 (0.89-1.08) in the entire study sample and 1.06 (0.93-1.21) in the sub-sample with 25(OH)D<45 nmol/L. This latter finding casts doubt on a strong causal association of 25(OH)D with T2D, but further research in large-scale consortia is needed.

Authors+Show Affiliations

Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Arthur-Scheunert-Allee 114-116, 14558, Nuthetal, Germany, brian.buijsse@dife.de.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24002339

Citation

Buijsse, Brian, et al. "Plasma 25-hydroxyvitamin D and Its Genetic Determinants in Relation to Incident Type 2 Diabetes: a Prospective Case-cohort Study." European Journal of Epidemiology, vol. 28, no. 9, 2013, pp. 743-52.
Buijsse B, Boeing H, Hirche F, et al. Plasma 25-hydroxyvitamin D and its genetic determinants in relation to incident type 2 diabetes: a prospective case-cohort study. Eur J Epidemiol. 2013;28(9):743-52.
Buijsse, B., Boeing, H., Hirche, F., Weikert, C., Schulze, M. B., Gottschald, M., Kühn, T., Katzke, V. A., Teucher, B., Dierkes, J., Stangl, G. I., & Kaaks, R. (2013). Plasma 25-hydroxyvitamin D and its genetic determinants in relation to incident type 2 diabetes: a prospective case-cohort study. European Journal of Epidemiology, 28(9), 743-52. https://doi.org/10.1007/s10654-013-9844-5
Buijsse B, et al. Plasma 25-hydroxyvitamin D and Its Genetic Determinants in Relation to Incident Type 2 Diabetes: a Prospective Case-cohort Study. Eur J Epidemiol. 2013;28(9):743-52. PubMed PMID: 24002339.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Plasma 25-hydroxyvitamin D and its genetic determinants in relation to incident type 2 diabetes: a prospective case-cohort study. AU - Buijsse,Brian, AU - Boeing,Heiner, AU - Hirche,Frank, AU - Weikert,Cornelia, AU - Schulze,Matthias B, AU - Gottschald,Marion, AU - Kühn,Tilman, AU - Katzke,Verena A, AU - Teucher,Birgit, AU - Dierkes,Jutta, AU - Stangl,Gabriele I, AU - Kaaks,Rudolf, Y1 - 2013/09/04/ PY - 2013/02/20/received PY - 2013/08/16/accepted PY - 2013/9/5/entrez PY - 2013/9/5/pubmed PY - 2013/12/24/medline SP - 743 EP - 52 JF - European journal of epidemiology JO - Eur J Epidemiol VL - 28 IS - 9 N2 - It is unclear whether vitamin D lowers risk of type 2 diabetes (T2D). In an observational study, we assessed the prospective association between plasma 25-hydroxyvitamin D (25(OH)D) and incident T2D, and evaluated whether it holds up for genetically determined elevated 25(OH)D. We used a case-cohort study nested within the German arm of the European Prospective Investigation into Cancer. From a total cohort of 53,088 participants with a mean follow-up of 6.6 years, we identified a random subcohort of 2,121 participants (57% women) and 1,572 incident cases of T2D. 25(OH)D was measured in baseline plasma samples retrieved from frozen storage. Mean plasma 25(OH)D in the subcohort was 47.1 (5th-95th percentile 19.6-80.7) nmol/L. After controlling for age, sex, center, season of blood draw, education, and lifestyle, the hazard of T2D decreased across increasing plasma concentrations of 25(OH)D (P linear trend<0.0001). The association became non-linear after adjustment for BMI and waist circumference (P non-linearity<0.0001), with the inverse association being restricted to participants with 25(OH)D concentrations below ~45 nmol/L (hazard ratio per 5 nmol/L higher 25(OH)D 0.91, 95% CI 0.84-0.98). A score predicting genetically determined plasma 25(OH)D by weighting four independent single-nucleotide polymorphisms by their effect on 25(OH)D, explained 3.7% of the variance in 25(OH)D. The hazard ratio (95% CI) per 5 nmol/L higher genetically predicted 25(OH)D was 0.98 (0.89-1.08) in the entire study sample and 1.06 (0.93-1.21) in the sub-sample with 25(OH)D<45 nmol/L. This latter finding casts doubt on a strong causal association of 25(OH)D with T2D, but further research in large-scale consortia is needed. SN - 1573-7284 UR - https://www.unboundmedicine.com/medline/citation/24002339/Plasma_25_hydroxyvitamin_D_and_its_genetic_determinants_in_relation_to_incident_type_2_diabetes:_a_prospective_case_cohort_study_ L2 - https://doi.org/10.1007/s10654-013-9844-5 DB - PRIME DP - Unbound Medicine ER -