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Pancreatic morphological changes in long-term follow-up after initial episode of acute alcoholic pancreatitis.
J Gastrointest Surg 2014; 18(1):164-70; discussion 170-1JG

Abstract

OBJECTIVE

The long-term morphological changes induced by a single episode of alcoholic pancreatitis are not known. Our aim was to study these morphological changes in secretin-stimulated magnetic resonance cholangiopancreatography (S-MRCP) after the first episode of alcohol-associated acute pancreatitis and to evaluate the risk factors and possible protective factors potentially associated with later chronic findings. We have previously reported 2-year follow-up results in pancreatic morphology. This study extends the follow-up to 9 years.

PATIENTS AND METHODS

In this prospective follow-up study, S-MRCP imaging was performed for 44 (41 M, 3 F; mean age, 46 (25-68) years) patients after their first episode of alcohol-associated pancreatitis. Pancreatic morphology was evaluated at 3 months and at 2, 7, and 9 years after hospitalization. Recurrent attacks of pancreatitis were studied and pancreatic function was monitored by laboratory tests. Patients' alcohol consumption was evaluated with questionnaires, laboratory markers, and self-estimated alcohol consumption via interview. Smoking and body mass index were annually recorded.

RESULTS

At 3 months, 32 % of the patients had normal findings in S-MRCP, 52 % had acute, and 16 % had chronic changes. At 7 years, S-MRCP was performed on 36 patients with normal findings in 53 %, the rest (47 %) having chronic findings. Pancreatic cyst was present in 36 %, parenchymal changes in 28 %, and atrophy in 28 % of the cases. There were no new changes in the pancreas in the attending patients between 7 and 9 years (18 patients). Of the patients with only acute findings at 3 months, 60 % resolved to normal in 7 years, but the rest (40 %) showed chronic changes later on. The initial attack was mild in 65 %, moderate in 25 %, and severe in 10 % of the patients. Patients with mild first attack had fewer chronic changes at 7 years compared to patients with moderate or moderate and severe together (p = 0.03, p = 0.01). Of the patients in the seventh year of S-MRCP, 22 % had suffered a recurrent episode of acute pancreatitis (mean, 22 (2-60) months) and 11 % had a clinical diagnosis of chronic pancreatitis. At 7 years, 88 % of the patients with recurrences had chronic findings in S-MRCP versus 36 % with nonrecurrent pancreatitis (p = 0.02). Six (17 %) patients abstained from alcohol throughout follow-up (mean, 8.7 (7-9.1) years), but even one of these developed pancreatic atrophy. Out of the non-abstinent patients who did not suffer recurrences, 4/22 (18 %) had developed new findings during at follow-up S-MRCP (NS). In univariate analysis, heavy smoking showed no correlation with increased chronic changes compared to nonsmoking.

CONCLUSIONS

Morphological pancreatic changes increase with recurrent episodes of acute pancreatitis. Patients with mild first attack have fewer chronic changes in the pancreas in the long term. However, even a single episode of acute alcoholic pancreatitis may induce chronic morphological changes in long-term follow-up.

Authors+Show Affiliations

School of Medicine, University of Tampere, Tampere, Finland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

24002755

Citation

Nikkola, Jussi, et al. "Pancreatic Morphological Changes in Long-term Follow-up After Initial Episode of Acute Alcoholic Pancreatitis." Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract, vol. 18, no. 1, 2014, pp. 164-70; discussion 170-1.
Nikkola J, Rinta-Kiikka I, Räty S, et al. Pancreatic morphological changes in long-term follow-up after initial episode of acute alcoholic pancreatitis. J Gastrointest Surg. 2014;18(1):164-70; discussion 170-1.
Nikkola, J., Rinta-Kiikka, I., Räty, S., Laukkarinen, J., Lappalainen-Lehto, R., Järvinen, S., ... Sand, J. (2014). Pancreatic morphological changes in long-term follow-up after initial episode of acute alcoholic pancreatitis. Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract, 18(1), pp. 164-70; discussion 170-1. doi:10.1007/s11605-013-2279-1.
Nikkola J, et al. Pancreatic Morphological Changes in Long-term Follow-up After Initial Episode of Acute Alcoholic Pancreatitis. J Gastrointest Surg. 2014;18(1):164-70; discussion 170-1. PubMed PMID: 24002755.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pancreatic morphological changes in long-term follow-up after initial episode of acute alcoholic pancreatitis. AU - Nikkola,Jussi, AU - Rinta-Kiikka,Irina, AU - Räty,Sari, AU - Laukkarinen,Johanna, AU - Lappalainen-Lehto,Riitta, AU - Järvinen,Satu, AU - Seppänen,Hanna, AU - Nordback,Isto, AU - Sand,Juhani, Y1 - 2013/09/04/ PY - 2013/05/14/received PY - 2013/06/24/accepted PY - 2013/9/5/entrez PY - 2013/9/5/pubmed PY - 2014/10/2/medline SP - 164-70; discussion 170-1 JF - Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract JO - J. Gastrointest. Surg. VL - 18 IS - 1 N2 - OBJECTIVE: The long-term morphological changes induced by a single episode of alcoholic pancreatitis are not known. Our aim was to study these morphological changes in secretin-stimulated magnetic resonance cholangiopancreatography (S-MRCP) after the first episode of alcohol-associated acute pancreatitis and to evaluate the risk factors and possible protective factors potentially associated with later chronic findings. We have previously reported 2-year follow-up results in pancreatic morphology. This study extends the follow-up to 9 years. PATIENTS AND METHODS: In this prospective follow-up study, S-MRCP imaging was performed for 44 (41 M, 3 F; mean age, 46 (25-68) years) patients after their first episode of alcohol-associated pancreatitis. Pancreatic morphology was evaluated at 3 months and at 2, 7, and 9 years after hospitalization. Recurrent attacks of pancreatitis were studied and pancreatic function was monitored by laboratory tests. Patients' alcohol consumption was evaluated with questionnaires, laboratory markers, and self-estimated alcohol consumption via interview. Smoking and body mass index were annually recorded. RESULTS: At 3 months, 32 % of the patients had normal findings in S-MRCP, 52 % had acute, and 16 % had chronic changes. At 7 years, S-MRCP was performed on 36 patients with normal findings in 53 %, the rest (47 %) having chronic findings. Pancreatic cyst was present in 36 %, parenchymal changes in 28 %, and atrophy in 28 % of the cases. There were no new changes in the pancreas in the attending patients between 7 and 9 years (18 patients). Of the patients with only acute findings at 3 months, 60 % resolved to normal in 7 years, but the rest (40 %) showed chronic changes later on. The initial attack was mild in 65 %, moderate in 25 %, and severe in 10 % of the patients. Patients with mild first attack had fewer chronic changes at 7 years compared to patients with moderate or moderate and severe together (p = 0.03, p = 0.01). Of the patients in the seventh year of S-MRCP, 22 % had suffered a recurrent episode of acute pancreatitis (mean, 22 (2-60) months) and 11 % had a clinical diagnosis of chronic pancreatitis. At 7 years, 88 % of the patients with recurrences had chronic findings in S-MRCP versus 36 % with nonrecurrent pancreatitis (p = 0.02). Six (17 %) patients abstained from alcohol throughout follow-up (mean, 8.7 (7-9.1) years), but even one of these developed pancreatic atrophy. Out of the non-abstinent patients who did not suffer recurrences, 4/22 (18 %) had developed new findings during at follow-up S-MRCP (NS). In univariate analysis, heavy smoking showed no correlation with increased chronic changes compared to nonsmoking. CONCLUSIONS: Morphological pancreatic changes increase with recurrent episodes of acute pancreatitis. Patients with mild first attack have fewer chronic changes in the pancreas in the long term. However, even a single episode of acute alcoholic pancreatitis may induce chronic morphological changes in long-term follow-up. SN - 1873-4626 UR - https://www.unboundmedicine.com/medline/citation/24002755/Pancreatic_morphological_changes_in_long_term_follow_up_after_initial_episode_of_acute_alcoholic_pancreatitis_ L2 - https://dx.doi.org/10.1007/s11605-013-2279-1 DB - PRIME DP - Unbound Medicine ER -