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Alpha thalassemia protects sickle cell anemia patients from macro-albuminuria through its effects on red blood cell rheological properties.
Clin Hemorheol Microcirc. 2014; 57(1):63-72.CH

Abstract

While chronic hemolysis has been suspected to be involved in the development of glomerulopathy in patients with sickle cell anemia (SCA), no study focused on the implications of blood rheology. Ninety-six adults with SCA at steady state were included in the present cross-sectional study. Three categories were defined: normo-albuminuria (NORMO, n = 41), micro-albuminuria (MICRO, n = 23) and macro-albuminuria (MACRO, n = 32). Blood was sampled to measure hematological and hemorheological parameters, and genomic DNA extraction was performed to detect the presence of α-thalassemia. The prevalence of α-thalassemia was lower in the MACRO group compared with the two other groups. Anemia was more severe in the MACRO compared with the NORMO group leading the former group to exhibit decreased blood viscosity. Red blood cell deformability was lower and red blood cell aggregates strength was greater in the MACRO compared to the two other groups, and this was directly attributed to the lower frequency of α-thalassemia in the former group. Our results show the protective role of α-thalassemia against the development of sickle cell glomerulopathy, and strongly suggest that this protection is mediated through the decrease of anemia, the increase of RBC deformability and the lowering of the RBC aggregates strength.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Lamarre Y
UMR 665 Inserm, Hôpital Ricou, CHU de Pointe-á-Pitre, Pointe-á-Pitre, Guadeloupe Université des Antilles et de la Guyane, Pointe-á-Pitre, Guadeloupe Laboratoire d'excellence GR-EX « The red cell: from genesis to death », PRES Sorbonne Paris Cité, Paris, France.
Romana M
UMR 665 Inserm, Hôpital Ricou, CHU de Pointe-á-Pitre, Pointe-á-Pitre, Guadeloupe Université des Antilles et de la Guyane, Pointe-á-Pitre, Guadeloupe Laboratoire d'excellence GR-EX « The red cell: from genesis to death », PRES Sorbonne Paris Cité, Paris, France.
Lemonne N
Unité Transversale de la Drépanocytose, CHU de Pointe-á-Pitre, Pointe-á-Pitre, Guadeloupe.
Hardy-Dessources MD
UMR 665 Inserm, Hôpital Ricou, CHU de Pointe-á-Pitre, Pointe-á-Pitre, Guadeloupe Université des Antilles et de la Guyane, Pointe-á-Pitre, Guadeloupe Laboratoire d'excellence GR-EX « The red cell: from genesis to death », PRES Sorbonne Paris Cité, Paris, France.
Tarer V
Unité Transversale de la Drépanocytose, CHU de Pointe-á-Pitre, Pointe-á-Pitre, Guadeloupe.
Mougenel D
Unité Transversale de la Drépanocytose, CHU de Pointe-á-Pitre, Pointe-á-Pitre, Guadeloupe.
Waltz X
UMR 665 Inserm, Hôpital Ricou, CHU de Pointe-á-Pitre, Pointe-á-Pitre, Guadeloupe Université des Antilles et de la Guyane, Pointe-á-Pitre, Guadeloupe Laboratoire d'excellence GR-EX « The red cell: from genesis to death », PRES Sorbonne Paris Cité, Paris, France Laboratoire ACTES, EA3596, Département de Physiologie, Guadeloupe.
Tressières B
CIC-EC 802 Inserm, Hôpital Ricou, CHU de Pointe-á-Pitre, Pointe-á-Pitre, Guadeloupe.
Lalanne-Mistrih ML
CIC-EC 802 Inserm, Hôpital Ricou, CHU de Pointe-á-Pitre, Pointe-á-Pitre, Guadeloupe.
Etienne-Julan M
Unité Transversale de la Drépanocytose, CHU de Pointe-á-Pitre, Pointe-á-Pitre, Guadeloupe.
Connes P
UMR 665 Inserm, Hôpital Ricou, CHU de Pointe-á-Pitre, Pointe-á-Pitre, Guadeloupe Université des Antilles et de la Guyane, Pointe-á-Pitre, Guadeloupe Laboratoire d'excellence GR-EX « The red cell: from genesis to death », PRES Sorbonne Paris Cité, Paris, France Laboratoire ACTES, EA3596, Département de Physiologie, Guadeloupe.

MeSH

AdultAlbuminuriaAnemia, Sickle CellBlood ViscosityCross-Sectional StudiesErythrocyte DeformabilityErythrocytesFemaleHemolysisHemorheologyHumansMaleMiddle AgedYoung Adultalpha-Thalassemia

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24004554

Citation

Lamarre, Yann, et al. "Alpha Thalassemia Protects Sickle Cell Anemia Patients From Macro-albuminuria Through Its Effects On Red Blood Cell Rheological Properties." Clinical Hemorheology and Microcirculation, vol. 57, no. 1, 2014, pp. 63-72.
Lamarre Y, Romana M, Lemonne N, et al. Alpha thalassemia protects sickle cell anemia patients from macro-albuminuria through its effects on red blood cell rheological properties. Clin Hemorheol Microcirc. 2014;57(1):63-72.
Lamarre, Y., Romana, M., Lemonne, N., Hardy-Dessources, M. D., Tarer, V., Mougenel, D., Waltz, X., Tressières, B., Lalanne-Mistrih, M. L., Etienne-Julan, M., & Connes, P. (2014). Alpha thalassemia protects sickle cell anemia patients from macro-albuminuria through its effects on red blood cell rheological properties. Clinical Hemorheology and Microcirculation, 57(1), 63-72. https://doi.org/10.3233/CH-131772
Lamarre Y, et al. Alpha Thalassemia Protects Sickle Cell Anemia Patients From Macro-albuminuria Through Its Effects On Red Blood Cell Rheological Properties. Clin Hemorheol Microcirc. 2014;57(1):63-72. PubMed PMID: 24004554.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alpha thalassemia protects sickle cell anemia patients from macro-albuminuria through its effects on red blood cell rheological properties. AU - Lamarre,Yann, AU - Romana,Marc, AU - Lemonne,Nathalie, AU - Hardy-Dessources,Marie-Dominique, AU - Tarer,Vanessa, AU - Mougenel,Danielle, AU - Waltz,Xavier, AU - Tressières,Benoît, AU - Lalanne-Mistrih,Marie-Laure, AU - Etienne-Julan,Maryse, AU - Connes,Philippe, PY - 2013/9/6/entrez PY - 2013/9/6/pubmed PY - 2015/2/3/medline KW - Sickle cell anemia KW - glomerulopathy KW - hemolysis KW - hemorheology SP - 63 EP - 72 JF - Clinical hemorheology and microcirculation JO - Clin Hemorheol Microcirc VL - 57 IS - 1 N2 - While chronic hemolysis has been suspected to be involved in the development of glomerulopathy in patients with sickle cell anemia (SCA), no study focused on the implications of blood rheology. Ninety-six adults with SCA at steady state were included in the present cross-sectional study. Three categories were defined: normo-albuminuria (NORMO, n = 41), micro-albuminuria (MICRO, n = 23) and macro-albuminuria (MACRO, n = 32). Blood was sampled to measure hematological and hemorheological parameters, and genomic DNA extraction was performed to detect the presence of α-thalassemia. The prevalence of α-thalassemia was lower in the MACRO group compared with the two other groups. Anemia was more severe in the MACRO compared with the NORMO group leading the former group to exhibit decreased blood viscosity. Red blood cell deformability was lower and red blood cell aggregates strength was greater in the MACRO compared to the two other groups, and this was directly attributed to the lower frequency of α-thalassemia in the former group. Our results show the protective role of α-thalassemia against the development of sickle cell glomerulopathy, and strongly suggest that this protection is mediated through the decrease of anemia, the increase of RBC deformability and the lowering of the RBC aggregates strength. SN - 1875-8622 UR - https://www.unboundmedicine.com/medline/citation/24004554/Alpha_thalassemia_protects_sickle_cell_anemia_patients_from_macro_albuminuria_through_its_effects_on_red_blood_cell_rheological_properties_ DB - PRIME DP - Unbound Medicine ER -