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Genetic aspects of auxin biosynthesis and its regulation.
Physiol Plant. 2014 May; 151(1):3-12.PP

Abstract

Auxin is an essential plant hormone that controls nearly every aspect of a plant's life, from embryo development to organ senescence. In the last decade the key genes involved in auxin transport, perception, signaling and response have been identified and characterized, but the elucidation of auxin biosynthesis has proven to be especially challenging. In plants, a significant amount of indole-3-acetic acid (IAA), the predominant biologically active form of auxin, is synthesized via a simple two-step route where indole-3-pyruvic acid (IPyA) produced from l-tryptophan by tryptophan aminotransferases (TAA1/TAR) is converted to IAA by the YUC family of flavin monooxygenases. The TAA1/TAR and YUC gene families constitute the first complete auxin biosynthetic pathway described in plants. Detailed characterization of these genes' expression patterns suggested a key role of local auxin biosynthesis in plant development. This has prompted an active search for the molecular mechanisms that regulate the spatiotemporal activity of the IPyA route. In addition to the TAA1/TAR and YUC-mediated auxin biosynthesis, several alternative routes of IAA production have been postulated to function in plants, but their biological significance is yet to be demonstrated. Herein, we take a genetic perspective to describe the current view of auxin biosynthesis and its regulation in plants, focusing primarily on Arabidopsis.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Brumos J
Department of Plant and Microbial Biology, North Carolina State University, Raleigh, NC, 27695, USA.
Alonso JM
No affiliation info available
Stepanova AN
No affiliation info available

MeSH

ArabidopsisArabidopsis ProteinsIndoleacetic AcidsMixed Function OxygenasesPlantsTryptophan Transaminase

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

24007561

Citation

Brumos, Javier, et al. "Genetic Aspects of Auxin Biosynthesis and Its Regulation." Physiologia Plantarum, vol. 151, no. 1, 2014, pp. 3-12.
Brumos J, Alonso JM, Stepanova AN. Genetic aspects of auxin biosynthesis and its regulation. Physiol Plant. 2014;151(1):3-12.
Brumos, J., Alonso, J. M., & Stepanova, A. N. (2014). Genetic aspects of auxin biosynthesis and its regulation. Physiologia Plantarum, 151(1), 3-12. https://doi.org/10.1111/ppl.12098
Brumos J, Alonso JM, Stepanova AN. Genetic Aspects of Auxin Biosynthesis and Its Regulation. Physiol Plant. 2014;151(1):3-12. PubMed PMID: 24007561.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Genetic aspects of auxin biosynthesis and its regulation. AU - Brumos,Javier, AU - Alonso,Jose M, AU - Stepanova,Anna N, Y1 - 2013/10/03/ PY - 2013/05/30/received PY - 2013/07/30/revised PY - 2013/08/15/accepted PY - 2013/9/7/entrez PY - 2013/9/7/pubmed PY - 2014/12/19/medline SP - 3 EP - 12 JF - Physiologia plantarum JO - Physiol Plant VL - 151 IS - 1 N2 - Auxin is an essential plant hormone that controls nearly every aspect of a plant's life, from embryo development to organ senescence. In the last decade the key genes involved in auxin transport, perception, signaling and response have been identified and characterized, but the elucidation of auxin biosynthesis has proven to be especially challenging. In plants, a significant amount of indole-3-acetic acid (IAA), the predominant biologically active form of auxin, is synthesized via a simple two-step route where indole-3-pyruvic acid (IPyA) produced from l-tryptophan by tryptophan aminotransferases (TAA1/TAR) is converted to IAA by the YUC family of flavin monooxygenases. The TAA1/TAR and YUC gene families constitute the first complete auxin biosynthetic pathway described in plants. Detailed characterization of these genes' expression patterns suggested a key role of local auxin biosynthesis in plant development. This has prompted an active search for the molecular mechanisms that regulate the spatiotemporal activity of the IPyA route. In addition to the TAA1/TAR and YUC-mediated auxin biosynthesis, several alternative routes of IAA production have been postulated to function in plants, but their biological significance is yet to be demonstrated. Herein, we take a genetic perspective to describe the current view of auxin biosynthesis and its regulation in plants, focusing primarily on Arabidopsis. SN - 1399-3054 UR - https://www.unboundmedicine.com/medline/citation/24007561/Genetic_aspects_of_auxin_biosynthesis_and_its_regulation_ DB - PRIME DP - Unbound Medicine ER -