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Antioxidant xanthones from Swertia mussotii, a high altitude plant.
Fitoterapia. 2013 Dec; 91:140-147.F

Abstract

Four new xanthones, 3,5,6,8-tetrahydroxyxanthone-1-C-β-D-glucoside (1), 7-hydroxy-3,4,8-trimethoxyxanthone-1-O-(β-D-glucoside) (2), 6-hydroxy-3,5-dimethoxyxanthone-1-O-(β-D-glucoside) (3), 3,4,7,8-tetramethoxyxanthone-1-O-(β-D-glucoside) (4), together with twenty-one known xanthones (5-25) were isolated from the ethanol aqueous extract of Swertia mussotii. Their structures were elucidated via spectroscopic analyses. Oxygen radical absorbance capacity of all the isolated xanthones was systematically evaluated by ORAC(FL) assay. Results disclose that all the tested xanthones display moderate to excellent antioxidant activity, where 1 is the most active compound and 13 is the least one. A preliminary structure-activity relationship is also discussed.

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Authors+Show Affiliations

Luo CT
Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, PR China.
Mao SS
Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, PR China.
Liu FL
Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, PR China.
Yang MX
Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, PR China.
Chen H
Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, PR China; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, PR China; Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Guangzhou 510632, PR China.
Kurihara H
Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, PR China; Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Guangzhou 510632, PR China.
Li Y
Northwest Institute of Plateau Biology, Chinese Academy of Sciences, Xining 810001, PR China.

MeSH

AltitudeAntioxidantsGlucosidesMolecular StructureOxidation-ReductionPlant ExtractsStructure-Activity RelationshipSwertiaXanthones

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24007984

Citation

Luo, Cui-Ting, et al. "Antioxidant Xanthones From Swertia Mussotii, a High Altitude Plant." Fitoterapia, vol. 91, 2013, pp. 140-147.
Luo CT, Mao SS, Liu FL, et al. Antioxidant xanthones from Swertia mussotii, a high altitude plant. Fitoterapia. 2013;91:140-147.
Luo, C. T., Mao, S. S., Liu, F. L., Yang, M. X., Chen, H., Kurihara, H., & Li, Y. (2013). Antioxidant xanthones from Swertia mussotii, a high altitude plant. Fitoterapia, 91, 140-147. https://doi.org/10.1016/j.fitote.2013.08.021
Luo CT, et al. Antioxidant Xanthones From Swertia Mussotii, a High Altitude Plant. Fitoterapia. 2013;91:140-147. PubMed PMID: 24007984.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antioxidant xanthones from Swertia mussotii, a high altitude plant. AU - Luo,Cui-Ting, AU - Mao,Shuang-Shuang, AU - Liu,Fang-Lan, AU - Yang,Mao-Xun, AU - Chen,Heru, AU - Kurihara,Hiroshi, AU - Li,Yulin, Y1 - 2013/09/02/ PY - 2013/07/20/received PY - 2013/08/22/revised PY - 2013/08/26/accepted PY - 2013/9/7/entrez PY - 2013/9/7/pubmed PY - 2014/6/3/medline KW - Antioxidant KW - ORAC KW - Swertia L. KW - Swertia mussotii KW - Xanthones SP - 140 EP - 147 JF - Fitoterapia JO - Fitoterapia VL - 91 N2 - Four new xanthones, 3,5,6,8-tetrahydroxyxanthone-1-C-β-D-glucoside (1), 7-hydroxy-3,4,8-trimethoxyxanthone-1-O-(β-D-glucoside) (2), 6-hydroxy-3,5-dimethoxyxanthone-1-O-(β-D-glucoside) (3), 3,4,7,8-tetramethoxyxanthone-1-O-(β-D-glucoside) (4), together with twenty-one known xanthones (5-25) were isolated from the ethanol aqueous extract of Swertia mussotii. Their structures were elucidated via spectroscopic analyses. Oxygen radical absorbance capacity of all the isolated xanthones was systematically evaluated by ORAC(FL) assay. Results disclose that all the tested xanthones display moderate to excellent antioxidant activity, where 1 is the most active compound and 13 is the least one. A preliminary structure-activity relationship is also discussed. SN - 1873-6971 UR - https://www.unboundmedicine.com/medline/citation/24007984/Antioxidant_xanthones_from_Swertia_mussotii_a_high_altitude_plant_ DB - PRIME DP - Unbound Medicine ER -