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Secretagogin-containing neurons in the mouse main olfactory bulb.
Neurosci Res 2013 Sep-Oct; 77(1-2):16-32NR

Abstract

Secretagogin (SCGN) is a recently discovered calcium binding protein of the EF hand family. We studied the structural features of SCGN-positive neurons in the mouse main olfactory bulb (MOB). SCGN-positive neurons were localized throughout layers but clustered in the glomerular layer (GL), mitral cell layer (MCL) and granule cell layer (GCL). They were heterogeneous, including numerous juxtaglomerular neurons, granule cells, small to medium-sized neurons in the external plexiform layer (EPL), and a few small cells in the ependymal/subependymal layer. Calretinin and/or tyrosine hydroxylase occasionally colocalized in SCGN-positive juxtaglomerular neurons. Calretinin also frequently colocalized in SCGN-positive EPL and GCL neurons. Morphologically some of juxtaglomerular SCGN-positive neurons were classical periglomerular cells, whereas others were apparently different from those periglomerular cells, although they were further heterogeneous. Some extended one slender process into a glomerulus which passed the glomerulus and further penetrated into another nearby glomeruli, and thus their dendritic processes spanned two or three or more glomeruli. We named this type of juxtaglomerular neurons "transglomerular cells." With the stereological analysis we estimated total number of juxtaglomerular SCGN-positive neurons at about 80,000/single MOB. The present study revealed the diversity of SCGN-positive neurons in the mouse MOB and their particular structural properties hitherto unknown.

Authors+Show Affiliations

Department of Health Sciences, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24008127

Citation

Kosaka, Katsuko, and Toshio Kosaka. "Secretagogin-containing Neurons in the Mouse Main Olfactory Bulb." Neuroscience Research, vol. 77, no. 1-2, 2013, pp. 16-32.
Kosaka K, Kosaka T. Secretagogin-containing neurons in the mouse main olfactory bulb. Neurosci Res. 2013;77(1-2):16-32.
Kosaka, K., & Kosaka, T. (2013). Secretagogin-containing neurons in the mouse main olfactory bulb. Neuroscience Research, 77(1-2), pp. 16-32. doi:10.1016/j.neures.2013.08.006.
Kosaka K, Kosaka T. Secretagogin-containing Neurons in the Mouse Main Olfactory Bulb. Neurosci Res. 2013;77(1-2):16-32. PubMed PMID: 24008127.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Secretagogin-containing neurons in the mouse main olfactory bulb. AU - Kosaka,Katsuko, AU - Kosaka,Toshio, Y1 - 2013/09/02/ PY - 2013/07/19/received PY - 2013/08/09/revised PY - 2013/08/09/accepted PY - 2013/9/7/entrez PY - 2013/9/7/pubmed PY - 2014/6/20/medline KW - 4′,6-diamidino-2-phenylindole KW - 5-bromo-2′-deoxyuridine KW - 5-ethynyl-2′-deoxyuridine KW - ABC KW - AOB KW - BDA KW - BSA KW - BrdU KW - CB KW - CLSM KW - CR KW - Calcium binding protein KW - Cy3 KW - Cy5 KW - DAB KW - DAPI KW - EM KW - EPL KW - EdU KW - FITC KW - GCL KW - GL KW - IPL KW - Local circuit neuron KW - MCL KW - MNL KW - MOB KW - MTL KW - NOS KW - OB KW - ON KW - ONL KW - Olfactory system KW - PB KW - PBS KW - PV KW - PaB KW - Periglomerular cell KW - RMS KW - SCGN KW - SEL KW - Short-axon cell KW - TH KW - VN KW - VNL KW - accessory olfactory bulb KW - avidin–biotin-peroxidase complex KW - biotinylated dextran amine KW - bovine serum albumin KW - calbindin D28k KW - calretinin KW - confocal laser scanning microscope KW - diaminobenzidine tetrahydrochloride KW - electron microscope KW - ependymal/subependymal layer KW - external plexiform layer KW - fluorescein isothiocyanate KW - glomerular layer KW - granule cell layer KW - indocarbocyanine KW - indodicarbocyanine KW - internal plexiform layer KW - main olfactory bulb KW - mitral and tufted cell layer of the accessory olfactory bulb KW - mitral cell layer KW - myelinated nerve layer of the accessory olfactory bulb KW - nitric oxide synthase KW - olfactory bulb KW - olfactory nerve layer KW - olfactory nerve/olfactory nerve terminal KW - pacific blue KW - pacific blue-conjugated streptavidin KW - parvalbumin KW - phosphate buffer KW - phosphate buffered saline KW - rostral migratory stream KW - secretagogin KW - stPaB KW - tyrosine hydroxylase KW - vomeronasal nerve KW - vomeronasal nerve layer SP - 16 EP - 32 JF - Neuroscience research JO - Neurosci. Res. VL - 77 IS - 1-2 N2 - Secretagogin (SCGN) is a recently discovered calcium binding protein of the EF hand family. We studied the structural features of SCGN-positive neurons in the mouse main olfactory bulb (MOB). SCGN-positive neurons were localized throughout layers but clustered in the glomerular layer (GL), mitral cell layer (MCL) and granule cell layer (GCL). They were heterogeneous, including numerous juxtaglomerular neurons, granule cells, small to medium-sized neurons in the external plexiform layer (EPL), and a few small cells in the ependymal/subependymal layer. Calretinin and/or tyrosine hydroxylase occasionally colocalized in SCGN-positive juxtaglomerular neurons. Calretinin also frequently colocalized in SCGN-positive EPL and GCL neurons. Morphologically some of juxtaglomerular SCGN-positive neurons were classical periglomerular cells, whereas others were apparently different from those periglomerular cells, although they were further heterogeneous. Some extended one slender process into a glomerulus which passed the glomerulus and further penetrated into another nearby glomeruli, and thus their dendritic processes spanned two or three or more glomeruli. We named this type of juxtaglomerular neurons "transglomerular cells." With the stereological analysis we estimated total number of juxtaglomerular SCGN-positive neurons at about 80,000/single MOB. The present study revealed the diversity of SCGN-positive neurons in the mouse MOB and their particular structural properties hitherto unknown. SN - 1872-8111 UR - https://www.unboundmedicine.com/medline/citation/24008127/Secretagogin_containing_neurons_in_the_mouse_main_olfactory_bulb_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0168-0102(13)00191-0 DB - PRIME DP - Unbound Medicine ER -