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Potential usefulness of mucin immunohistochemical staining of preoperative pancreatic biopsy or juice cytology specimens in the determination of treatment strategies for intraductal papillary mucinous neoplasm.
Oncol Rep. 2013 Nov; 30(5):2035-41.OR

Abstract

We classified resected intraductal papillary mucinous neoplasms (IPMNs) into four subtypes (gastric, intestinal, pancreatobiliary and oncocytic) according to their morphological features and mucin expression, determined their clinicopathological characteristics and investigated the possibility of preoperatively diagnosing these subtypes. Sixty resected tumors, 4 preoperative tumor biopsies and 10 preoperative pancreatic juice cytology specimens were analyzed. The gastric and intestinal types accounted for the majority of IPMNs. Non-gastric type IPMNs were of high-grade malignancy. Many of the pancreatobiliary-type IPMNs were in an advanced stage and were associated with a poor prognosis. The results of mucin immunohistochemical staining of preoperative biopsy and surgically resected specimens were in agreement with each other, and in close agreement with those for pancreatic juice cytology specimens obtained from 10 patients during endoscopic retrograde cholangiopancreatography (ERCP). The immunostaining of preoperative biopsy specimens and ERCP-obtained pancreatic juice cytology specimens may be useful in the differential diagnosis of gastric and intestinal types of IPMN. If such techniques enable the preoperative diagnosis of IPMN subtypes, their use in combination with conventional preoperative imaging modalities may lead to surgical treatment best suited for the biological characteristics of the four subtypes.

Authors+Show Affiliations

Department of Surgery, Kurume University School of Medicine, Kurume, Fukuoka 830-0011, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

24008495

Citation

Hisaka, Toru, et al. "Potential Usefulness of Mucin Immunohistochemical Staining of Preoperative Pancreatic Biopsy or Juice Cytology Specimens in the Determination of Treatment Strategies for Intraductal Papillary Mucinous Neoplasm." Oncology Reports, vol. 30, no. 5, 2013, pp. 2035-41.
Hisaka T, Horiuchi H, Uchida S, et al. Potential usefulness of mucin immunohistochemical staining of preoperative pancreatic biopsy or juice cytology specimens in the determination of treatment strategies for intraductal papillary mucinous neoplasm. Oncol Rep. 2013;30(5):2035-41.
Hisaka, T., Horiuchi, H., Uchida, S., Ishikawa, H., Kawahara, R., Kawashima, Y., Akashi, M., Mikagi, K., Ishida, Y., Okabe, Y., Nakayama, M., Naito, Y., Yano, H., Taira, T., Kawahara, A., Kage, M., Kinoshita, H., & Shirozu, K. (2013). Potential usefulness of mucin immunohistochemical staining of preoperative pancreatic biopsy or juice cytology specimens in the determination of treatment strategies for intraductal papillary mucinous neoplasm. Oncology Reports, 30(5), 2035-41. https://doi.org/10.3892/or.2013.2720
Hisaka T, et al. Potential Usefulness of Mucin Immunohistochemical Staining of Preoperative Pancreatic Biopsy or Juice Cytology Specimens in the Determination of Treatment Strategies for Intraductal Papillary Mucinous Neoplasm. Oncol Rep. 2013;30(5):2035-41. PubMed PMID: 24008495.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Potential usefulness of mucin immunohistochemical staining of preoperative pancreatic biopsy or juice cytology specimens in the determination of treatment strategies for intraductal papillary mucinous neoplasm. AU - Hisaka,Toru, AU - Horiuchi,Hiroyuki, AU - Uchida,Shinji, AU - Ishikawa,Hiroto, AU - Kawahara,Ryuichi, AU - Kawashima,Yusuke, AU - Akashi,Masanori, AU - Mikagi,Kazuhiro, AU - Ishida,Yusuke, AU - Okabe,Yoshinobu, AU - Nakayama,Masamichi, AU - Naito,Yoshiki, AU - Yano,Hirohisa, AU - Taira,Tomoki, AU - Kawahara,Akihiko, AU - Kage,Masayoshi, AU - Kinoshita,Hisafumi, AU - Shirozu,Kazuo, Y1 - 2013/09/05/ PY - 2013/07/09/received PY - 2013/08/09/accepted PY - 2013/9/7/entrez PY - 2013/9/7/pubmed PY - 2014/4/8/medline SP - 2035 EP - 41 JF - Oncology reports JO - Oncol Rep VL - 30 IS - 5 N2 - We classified resected intraductal papillary mucinous neoplasms (IPMNs) into four subtypes (gastric, intestinal, pancreatobiliary and oncocytic) according to their morphological features and mucin expression, determined their clinicopathological characteristics and investigated the possibility of preoperatively diagnosing these subtypes. Sixty resected tumors, 4 preoperative tumor biopsies and 10 preoperative pancreatic juice cytology specimens were analyzed. The gastric and intestinal types accounted for the majority of IPMNs. Non-gastric type IPMNs were of high-grade malignancy. Many of the pancreatobiliary-type IPMNs were in an advanced stage and were associated with a poor prognosis. The results of mucin immunohistochemical staining of preoperative biopsy and surgically resected specimens were in agreement with each other, and in close agreement with those for pancreatic juice cytology specimens obtained from 10 patients during endoscopic retrograde cholangiopancreatography (ERCP). The immunostaining of preoperative biopsy specimens and ERCP-obtained pancreatic juice cytology specimens may be useful in the differential diagnosis of gastric and intestinal types of IPMN. If such techniques enable the preoperative diagnosis of IPMN subtypes, their use in combination with conventional preoperative imaging modalities may lead to surgical treatment best suited for the biological characteristics of the four subtypes. SN - 1791-2431 UR - https://www.unboundmedicine.com/medline/citation/24008495/Potential_usefulness_of_mucin_immunohistochemical_staining_of_preoperative_pancreatic_biopsy_or_juice_cytology_specimens_in_the_determination_of_treatment_strategies_for_intraductal_papillary_mucinous_neoplasm_ L2 - http://www.spandidos-publications.com/or/30/5/2035 DB - PRIME DP - Unbound Medicine ER -