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Pentacyclic triterpenes from Terminalia arjuna show multiple benefits on aged and dry skin.
Skin Pharmacol Physiol. 2014; 27(2):71-81.SP

Abstract

BACKGROUND

Pentacyclic triterpenoids improve epidermal barrier function and induce collagen production. Here, their effects on cutaneous aging by means of objective instrumental measurements were elucidated.

METHODS

Reconstituted human epidermis, cultivated keratinocytes and fibroblasts were incubated with Terminalia arjuna triterpenes (T. arjuna bark extract), and mRNA and protein expression of various genes was determined using microarray analysis, qRT-PCR and ELISA techniques. Clinical efficacy of T. arjuna bark extract versus vehicle control cream was elucidated in 30 patients and transepidermal water loss (TEWL), skin hydration and elasticity were measured. Another 30 female patients in their postmenopausal phase were treated with a similar regime, and skin sebum content, cutaneous blood microcirculation and skin density/echogenicity were assessed.

RESULTS

Incubation with T. arjuna triterpenes increased FGF-2, TSP-1, TGF-β and CTGF expression, and VEGF secretion in vitro. Elevated lactate dehydrogenase release upon sodium dodecyl sulphate challenge was reversed by the application of T. arjuna bark extract. T. arjuna bark extract decreased TEWL, improved skin moisturization, reduced scaliness and led to significantly improved skin elasticity. Also, increases in blood microflow and skin sebum content as well as improved skin thickness/echogenicity were noted on postmenopausal skin, resulting in visible reduction of sagging skin on the jowls as demonstrated by digital photography.

CONCLUSION

T. arjuna bark extract appears as an innovative active ingredient that exerts versatile antiaging properties in vitro and in vivo.

Authors+Show Affiliations

Evonik Industries AG, Essen, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Controlled Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24008587

Citation

Farwick, M, et al. "Pentacyclic Triterpenes From Terminalia Arjuna Show Multiple Benefits On Aged and Dry Skin." Skin Pharmacology and Physiology, vol. 27, no. 2, 2014, pp. 71-81.
Farwick M, Köhler T, Schild J, et al. Pentacyclic triterpenes from Terminalia arjuna show multiple benefits on aged and dry skin. Skin Pharmacol Physiol. 2014;27(2):71-81.
Farwick, M., Köhler, T., Schild, J., Mentel, M., Maczkiewitz, U., Pagani, V., Bonfigli, A., Rigano, L., Bureik, D., & Gauglitz, G. G. (2014). Pentacyclic triterpenes from Terminalia arjuna show multiple benefits on aged and dry skin. Skin Pharmacology and Physiology, 27(2), 71-81. https://doi.org/10.1159/000351387
Farwick M, et al. Pentacyclic Triterpenes From Terminalia Arjuna Show Multiple Benefits On Aged and Dry Skin. Skin Pharmacol Physiol. 2014;27(2):71-81. PubMed PMID: 24008587.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pentacyclic triterpenes from Terminalia arjuna show multiple benefits on aged and dry skin. AU - Farwick,M, AU - Köhler,T, AU - Schild,J, AU - Mentel,M, AU - Maczkiewitz,U, AU - Pagani,V, AU - Bonfigli,A, AU - Rigano,L, AU - Bureik,D, AU - Gauglitz,G G, Y1 - 2013/09/05/ PY - 2012/11/26/received PY - 2013/03/24/accepted PY - 2013/9/7/entrez PY - 2013/9/7/pubmed PY - 2014/9/5/medline SP - 71 EP - 81 JF - Skin pharmacology and physiology JO - Skin Pharmacol Physiol VL - 27 IS - 2 N2 - BACKGROUND: Pentacyclic triterpenoids improve epidermal barrier function and induce collagen production. Here, their effects on cutaneous aging by means of objective instrumental measurements were elucidated. METHODS: Reconstituted human epidermis, cultivated keratinocytes and fibroblasts were incubated with Terminalia arjuna triterpenes (T. arjuna bark extract), and mRNA and protein expression of various genes was determined using microarray analysis, qRT-PCR and ELISA techniques. Clinical efficacy of T. arjuna bark extract versus vehicle control cream was elucidated in 30 patients and transepidermal water loss (TEWL), skin hydration and elasticity were measured. Another 30 female patients in their postmenopausal phase were treated with a similar regime, and skin sebum content, cutaneous blood microcirculation and skin density/echogenicity were assessed. RESULTS: Incubation with T. arjuna triterpenes increased FGF-2, TSP-1, TGF-β and CTGF expression, and VEGF secretion in vitro. Elevated lactate dehydrogenase release upon sodium dodecyl sulphate challenge was reversed by the application of T. arjuna bark extract. T. arjuna bark extract decreased TEWL, improved skin moisturization, reduced scaliness and led to significantly improved skin elasticity. Also, increases in blood microflow and skin sebum content as well as improved skin thickness/echogenicity were noted on postmenopausal skin, resulting in visible reduction of sagging skin on the jowls as demonstrated by digital photography. CONCLUSION: T. arjuna bark extract appears as an innovative active ingredient that exerts versatile antiaging properties in vitro and in vivo. SN - 1660-5535 UR - https://www.unboundmedicine.com/medline/citation/24008587/Pentacyclic_triterpenes_from_Terminalia_arjuna_show_multiple_benefits_on_aged_and_dry_skin_ L2 - https://www.karger.com?DOI=10.1159/000351387 DB - PRIME DP - Unbound Medicine ER -