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Comparison of interleukin-17- producing cells in different clinical types of alopecia areata.
Dermatology. 2013; 227(1):78-82.D

Abstract

T helper 17 cells, characterized by interleukin-17 (IL-17) production, play a critical role in the pathogenesis of autoimmune disease, including alopecia areata (AA). In this report, we employed immunohistochemical staining for IL-17-producing cells, as well as interferon-γ-producing cells, granulysin-bearing cells and Foxp3+ regulatory T cells, and performed a quantitative analysis of IL-17-producing cells in the lesional skin of several clinical forms of AA by TissueFAXS analysis. Among them, interestingly, the ratio of IL-17-producing cells in acute, diffuse and total alopecia was significantly lower than those of multiple types of AA. Our study sheds light on one of the possible immunological mechanisms of AA.

Authors+Show Affiliations

Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

24008930

Citation

Tojo, Genichi, et al. "Comparison of Interleukin-17- Producing Cells in Different Clinical Types of Alopecia Areata." Dermatology (Basel, Switzerland), vol. 227, no. 1, 2013, pp. 78-82.
Tojo G, Fujimura T, Kawano M, et al. Comparison of interleukin-17- producing cells in different clinical types of alopecia areata. Dermatology (Basel). 2013;227(1):78-82.
Tojo, G., Fujimura, T., Kawano, M., Ogasawara, K., Kambayashi, Y., Furudate, S., Mizuashi, M., & Aiba, S. (2013). Comparison of interleukin-17- producing cells in different clinical types of alopecia areata. Dermatology (Basel, Switzerland), 227(1), 78-82. https://doi.org/10.1159/000353159
Tojo G, et al. Comparison of Interleukin-17- Producing Cells in Different Clinical Types of Alopecia Areata. Dermatology (Basel). 2013;227(1):78-82. PubMed PMID: 24008930.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of interleukin-17- producing cells in different clinical types of alopecia areata. AU - Tojo,Genichi, AU - Fujimura,Taku, AU - Kawano,Mitsuko, AU - Ogasawara,Kouetsu, AU - Kambayashi,Yumi, AU - Furudate,Sadanori, AU - Mizuashi,Masato, AU - Aiba,Setsuya, Y1 - 2013/08/30/ PY - 2013/02/12/received PY - 2013/05/15/accepted PY - 2013/9/7/entrez PY - 2013/9/7/pubmed PY - 2014/6/16/medline SP - 78 EP - 82 JF - Dermatology (Basel, Switzerland) JO - Dermatology (Basel) VL - 227 IS - 1 N2 - T helper 17 cells, characterized by interleukin-17 (IL-17) production, play a critical role in the pathogenesis of autoimmune disease, including alopecia areata (AA). In this report, we employed immunohistochemical staining for IL-17-producing cells, as well as interferon-γ-producing cells, granulysin-bearing cells and Foxp3+ regulatory T cells, and performed a quantitative analysis of IL-17-producing cells in the lesional skin of several clinical forms of AA by TissueFAXS analysis. Among them, interestingly, the ratio of IL-17-producing cells in acute, diffuse and total alopecia was significantly lower than those of multiple types of AA. Our study sheds light on one of the possible immunological mechanisms of AA. SN - 1421-9832 UR - https://www.unboundmedicine.com/medline/citation/24008930/Comparison_of_interleukin_17__producing_cells_in_different_clinical_types_of_alopecia_areata_ L2 - https://www.karger.com?DOI=10.1159/000353159 DB - PRIME DP - Unbound Medicine ER -