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Diagnosis of alcohol misuse and alcoholic liver disease among patients in the medical emergency admission service of a large urban hospital in Sub-Saharan Africa; a cross sectional study.
Pan Afr Med J. 2013; 15:23.PA

Abstract

INTRODUCTION

Uganda is among the top ten consumers of alcohol worldwide though there is little data on alcohol related liver disease. We describe alcohol use, alcohol misuse, and alcoholic liver disease among adults at the emergency admission service of a large urban hospital in Uganda.

METHODS

All adults who consented were prospectively evaluated for alcohol use by inquiry and alcohol misuse by the "Cutting down, Annoyance, Guilt and Eye-opener- CAGE" questionnaire. Alcohol related hepatocellular liver injury was assessed using aspartate aminotransferase, and alanine aminotransferase levels. A combination of CAGE score ≥2 and De Ritis ratio ≥2 defined alcoholic liver disease (ALD). Human Immunodeficiency Virus (HIV), and viral hepatitis B and C serologies were evaluated in all the patients. Descriptive and inferential statistics were generated to answer our research questions.

RESULTS

Three hundred and eighty individuals consented and participated in the study. Among these, 46.8% acknowledged use of alcohol while 21% and 10% met the study definition of alcoholic misuse and alcoholic liver disease respectively. Both alcohol misuse and alcoholic liver disease was significantly associated (p-value ≤ 0.05) with male gender, region of origin, number of life time sexual partners and serum albumin below 3.5 mg/dl after univariate and multivariate analysis.

CONCLUSION

Alcohol misuse and alcoholic liver disease is frequent in this medical emergency unit. Our study suggests a link between alcohol misuse or alcoholic liver disease and male gender, region of origin, number of sexual partners, and serum albumin below 3.5mg/dl.

Authors+Show Affiliations

Department of Medicine, Makerere University College of Health Sciences P.O.Box 7072, Kampala, Uganda.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

24009799

Citation

Opio, Christopher Kenneth, et al. "Diagnosis of Alcohol Misuse and Alcoholic Liver Disease Among Patients in the Medical Emergency Admission Service of a Large Urban Hospital in Sub-Saharan Africa; a Cross Sectional Study." The Pan African Medical Journal, vol. 15, 2013, p. 23.
Opio CK, Seremba E, Ocama P, et al. Diagnosis of alcohol misuse and alcoholic liver disease among patients in the medical emergency admission service of a large urban hospital in Sub-Saharan Africa; a cross sectional study. Pan Afr Med J. 2013;15:23.
Opio, C. K., Seremba, E., Ocama, P., Lalitha, R., Kagimu, M., & Lee, W. M. (2013). Diagnosis of alcohol misuse and alcoholic liver disease among patients in the medical emergency admission service of a large urban hospital in Sub-Saharan Africa; a cross sectional study. The Pan African Medical Journal, 15, 23. https://doi.org/10.11604/pamj.2013.15.23.2040
Opio CK, et al. Diagnosis of Alcohol Misuse and Alcoholic Liver Disease Among Patients in the Medical Emergency Admission Service of a Large Urban Hospital in Sub-Saharan Africa; a Cross Sectional Study. Pan Afr Med J. 2013;15:23. PubMed PMID: 24009799.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diagnosis of alcohol misuse and alcoholic liver disease among patients in the medical emergency admission service of a large urban hospital in Sub-Saharan Africa; a cross sectional study. AU - Opio,Christopher Kenneth, AU - Seremba,Emmanuel, AU - Ocama,Ponciano, AU - Lalitha,Rejani, AU - Kagimu,Magid, AU - Lee,William Martens, Y1 - 2013/05/13/ PY - 2012/09/15/received PY - 2013/02/12/accepted PY - 2013/9/7/entrez PY - 2013/9/7/pubmed PY - 2014/2/11/medline KW - Alcohol use KW - CAGE questionnaire KW - De Ritis ratio KW - alanine aminotransferase KW - alcohol misuse KW - alcoholic liver disease KW - aspartate aminotransferase SP - 23 EP - 23 JF - The Pan African medical journal JO - Pan Afr Med J VL - 15 N2 - INTRODUCTION: Uganda is among the top ten consumers of alcohol worldwide though there is little data on alcohol related liver disease. We describe alcohol use, alcohol misuse, and alcoholic liver disease among adults at the emergency admission service of a large urban hospital in Uganda. METHODS: All adults who consented were prospectively evaluated for alcohol use by inquiry and alcohol misuse by the "Cutting down, Annoyance, Guilt and Eye-opener- CAGE" questionnaire. Alcohol related hepatocellular liver injury was assessed using aspartate aminotransferase, and alanine aminotransferase levels. A combination of CAGE score ≥2 and De Ritis ratio ≥2 defined alcoholic liver disease (ALD). Human Immunodeficiency Virus (HIV), and viral hepatitis B and C serologies were evaluated in all the patients. Descriptive and inferential statistics were generated to answer our research questions. RESULTS: Three hundred and eighty individuals consented and participated in the study. Among these, 46.8% acknowledged use of alcohol while 21% and 10% met the study definition of alcoholic misuse and alcoholic liver disease respectively. Both alcohol misuse and alcoholic liver disease was significantly associated (p-value ≤ 0.05) with male gender, region of origin, number of life time sexual partners and serum albumin below 3.5 mg/dl after univariate and multivariate analysis. CONCLUSION: Alcohol misuse and alcoholic liver disease is frequent in this medical emergency unit. Our study suggests a link between alcohol misuse or alcoholic liver disease and male gender, region of origin, number of sexual partners, and serum albumin below 3.5mg/dl. SN - 1937-8688 UR - https://www.unboundmedicine.com/medline/citation/24009799/Diagnosis_of_alcohol_misuse_and_alcoholic_liver_disease_among_patients_in_the_medical_emergency_admission_service_of_a_large_urban_hospital_in_Sub_Saharan_Africa L2 - https://www.panafrican-med-journal.com/content/article/15/23/full/ DB - PRIME DP - Unbound Medicine ER -