Tags

Type your tag names separated by a space and hit enter

Three paraneoplastic signs in the same patient with gastric adenocarcinoma.
Dermatol Online J. 2013 Jul 14; 19(7):18966.DO

Abstract

This is the report of a 76-year-old male with typical lesions of acanthosis nigricans maligna (ANM), florid cutaneous papillomatosis (FCP), and tripe palms (TP) for 2 years. He did not have any gastrointestinal complaints. Pathologic findings of skin supported the diagnosis of ANM. Because gastric adenocarcinoma is the most common neoplasm associated with these paraneoplastic dermatoses, further tests were carried out. Endoscopic examination was performed and an adenocarcinoma of the esophagogastric junction was confirmed. Meanwhile, multiple small polyps in the middle and the lower thirds of the esophagus were observed. The patient was referred for further evaluation and subsequent surgical resection of the tumor.Acanthosis nigricans (AN) is a hyperkeratotic mucocutaneous eruption of heterogenous etiology, which is characterized by hyperpigmentation, velvety cutaneous thickening, intensified skin markings, and development of verrucous excrescences typically involving the intertriginous areas. AN is classified into benign and malignant forms on the basis of clinical associations. Malignant acanthosis nigricans (MAN) tends to be extensive and involves mucosal surfaces, mostly in elderly people. Florid cutaneous papillomatosis (FCP), also known as the Schwartz-Burgess syndrome, is characterized by the rapid appearance of multiple verrucous lesions that are clinically indistinguishable from common warts [1]. Tripe palms (TP) is characterized by diffuse, yellowish palmar hyperkeratosis, with enhancement of the epidermal ridges on the hands (dermatoglyphics), resembling intestinal villosities [1]. The association of these three paraneoplastic dermatoses (FCP, ANM and TP) in the same patient has been reported. Herein, we report an elderly male with three paraneoplastic dermatoses for two years. On the initial presentation, he did not report any systemic complaints; diagnostic tests confirmed the presence of a gastric adenocarcinoma.

Authors+Show Affiliations

Yang YH
Third Affiliated Hospital of Suzhou University. 185 Juqian Road, Changzhou, China.
Zhang RZ
No affiliation info available
Kang DH
No affiliation info available
Zhu WY
No affiliation info available

MeSH

Acanthosis NigricansAdenocarcinomaAgedHand DermatosesHumansKeratoderma, PalmoplantarMalePapillomaParaneoplastic SyndromesSkin NeoplasmsStomach Neoplasms

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

24010512

Citation

Yang, Yu-hua, et al. "Three Paraneoplastic Signs in the Same Patient With Gastric Adenocarcinoma." Dermatology Online Journal, vol. 19, no. 7, 2013, p. 18966.
Yang YH, Zhang RZ, Kang DH, et al. Three paraneoplastic signs in the same patient with gastric adenocarcinoma. Dermatol Online J. 2013;19(7):18966.
Yang, Y. H., Zhang, R. Z., Kang, D. H., & Zhu, W. Y. (2013). Three paraneoplastic signs in the same patient with gastric adenocarcinoma. Dermatology Online Journal, 19(7), 18966.
Yang YH, et al. Three Paraneoplastic Signs in the Same Patient With Gastric Adenocarcinoma. Dermatol Online J. 2013 Jul 14;19(7):18966. PubMed PMID: 24010512.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Three paraneoplastic signs in the same patient with gastric adenocarcinoma. AU - Yang,Yu-hua, AU - Zhang,Ru-zhi, AU - Kang,Ding-hua, AU - Zhu,Wen-yuan, Y1 - 2013/07/14/ PY - 2013/07/11/received PY - 2013/07/11/accepted PY - 2013/9/10/entrez PY - 2013/9/10/pubmed PY - 2014/5/7/medline SP - 18966 EP - 18966 JF - Dermatology online journal JO - Dermatol Online J VL - 19 IS - 7 N2 - This is the report of a 76-year-old male with typical lesions of acanthosis nigricans maligna (ANM), florid cutaneous papillomatosis (FCP), and tripe palms (TP) for 2 years. He did not have any gastrointestinal complaints. Pathologic findings of skin supported the diagnosis of ANM. Because gastric adenocarcinoma is the most common neoplasm associated with these paraneoplastic dermatoses, further tests were carried out. Endoscopic examination was performed and an adenocarcinoma of the esophagogastric junction was confirmed. Meanwhile, multiple small polyps in the middle and the lower thirds of the esophagus were observed. The patient was referred for further evaluation and subsequent surgical resection of the tumor.Acanthosis nigricans (AN) is a hyperkeratotic mucocutaneous eruption of heterogenous etiology, which is characterized by hyperpigmentation, velvety cutaneous thickening, intensified skin markings, and development of verrucous excrescences typically involving the intertriginous areas. AN is classified into benign and malignant forms on the basis of clinical associations. Malignant acanthosis nigricans (MAN) tends to be extensive and involves mucosal surfaces, mostly in elderly people. Florid cutaneous papillomatosis (FCP), also known as the Schwartz-Burgess syndrome, is characterized by the rapid appearance of multiple verrucous lesions that are clinically indistinguishable from common warts [1]. Tripe palms (TP) is characterized by diffuse, yellowish palmar hyperkeratosis, with enhancement of the epidermal ridges on the hands (dermatoglyphics), resembling intestinal villosities [1]. The association of these three paraneoplastic dermatoses (FCP, ANM and TP) in the same patient has been reported. Herein, we report an elderly male with three paraneoplastic dermatoses for two years. On the initial presentation, he did not report any systemic complaints; diagnostic tests confirmed the presence of a gastric adenocarcinoma. SN - 1087-2108 UR - https://www.unboundmedicine.com/medline/citation/24010512/Three_paraneoplastic_signs_in_the_same_patient_with_gastric_adenocarcinoma_ DB - PRIME DP - Unbound Medicine ER -