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Effects of antipsychotic medications on appetite, weight, and insulin resistance.
Endocrinol Metab Clin North Am. 2013 Sep; 42(3):545-63.EM

Abstract

Although clozapine, olanzapine, and other atypical antipsychotic drugs (APDs) have fewer extrapyramidal side effects, they have serious metabolic side effects such as substantial weight gain, intra-abdominal obesity, and type 2 diabetes mellitus. Given that most patients with mental disorders face chronic, even life-long, treatment with APDs, the risks of weight gain/obesity and other metabolic symptoms are major considerations for APD maintenance treatment. This review focuses on the effects of APDs on weight gain, appetite, insulin resistance, and glucose dysregulation, and the relevant underlying mechanisms that may be help to prevent and treat metabolic side effects caused by APD therapy.

Authors+Show Affiliations

Antipsychotic Research Laboratory, School of Health Sciences, Illawarra Health and Medical Research Institute, University of Wollongong, Northfields Avenue, Wollongong, New South Wales 2522, Australia. chao@uow.edu.au

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

24011886

Citation

Deng, Chao. "Effects of Antipsychotic Medications On Appetite, Weight, and Insulin Resistance." Endocrinology and Metabolism Clinics of North America, vol. 42, no. 3, 2013, pp. 545-63.
Deng C. Effects of antipsychotic medications on appetite, weight, and insulin resistance. Endocrinol Metab Clin North Am. 2013;42(3):545-63.
Deng, C. (2013). Effects of antipsychotic medications on appetite, weight, and insulin resistance. Endocrinology and Metabolism Clinics of North America, 42(3), 545-63. https://doi.org/10.1016/j.ecl.2013.05.006
Deng C. Effects of Antipsychotic Medications On Appetite, Weight, and Insulin Resistance. Endocrinol Metab Clin North Am. 2013;42(3):545-63. PubMed PMID: 24011886.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of antipsychotic medications on appetite, weight, and insulin resistance. A1 - Deng,Chao, PY - 2013/9/10/entrez PY - 2013/9/10/pubmed PY - 2014/4/17/medline KW - Antipsychotic KW - Appetite KW - Glucose dysregulation KW - Insulin resistance KW - Obesity KW - Weight gain SP - 545 EP - 63 JF - Endocrinology and metabolism clinics of North America JO - Endocrinol Metab Clin North Am VL - 42 IS - 3 N2 - Although clozapine, olanzapine, and other atypical antipsychotic drugs (APDs) have fewer extrapyramidal side effects, they have serious metabolic side effects such as substantial weight gain, intra-abdominal obesity, and type 2 diabetes mellitus. Given that most patients with mental disorders face chronic, even life-long, treatment with APDs, the risks of weight gain/obesity and other metabolic symptoms are major considerations for APD maintenance treatment. This review focuses on the effects of APDs on weight gain, appetite, insulin resistance, and glucose dysregulation, and the relevant underlying mechanisms that may be help to prevent and treat metabolic side effects caused by APD therapy. SN - 1558-4410 UR - https://www.unboundmedicine.com/medline/citation/24011886/Effects_of_antipsychotic_medications_on_appetite_weight_and_insulin_resistance_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0889-8529(13)00041-8 DB - PRIME DP - Unbound Medicine ER -