Citation
Palacios-González, Berenice, et al. "Genistein Stimulates Fatty Acid Oxidation in a Leptin Receptor-independent Manner Through the JAK2-mediated Phosphorylation and Activation of AMPK in Skeletal Muscle." Biochimica Et Biophysica Acta, vol. 1841, no. 1, 2014, pp. 132-40.
Palacios-González B, Zarain-Herzberg A, Flores-Galicia I, et al. Genistein stimulates fatty acid oxidation in a leptin receptor-independent manner through the JAK2-mediated phosphorylation and activation of AMPK in skeletal muscle. Biochim Biophys Acta. 2014;1841(1):132-40.
Palacios-González, B., Zarain-Herzberg, A., Flores-Galicia, I., Noriega, L. G., Alemán-Escondrillas, G., Zariñan, T., Ulloa-Aguirre, A., Torres, N., & Tovar, A. R. (2014). Genistein stimulates fatty acid oxidation in a leptin receptor-independent manner through the JAK2-mediated phosphorylation and activation of AMPK in skeletal muscle. Biochimica Et Biophysica Acta, 1841(1), 132-40. https://doi.org/10.1016/j.bbalip.2013.08.018
Palacios-González B, et al. Genistein Stimulates Fatty Acid Oxidation in a Leptin Receptor-independent Manner Through the JAK2-mediated Phosphorylation and Activation of AMPK in Skeletal Muscle. Biochim Biophys Acta. 2014;1841(1):132-40. PubMed PMID: 24013029.
TY - JOUR
T1 - Genistein stimulates fatty acid oxidation in a leptin receptor-independent manner through the JAK2-mediated phosphorylation and activation of AMPK in skeletal muscle.
AU - Palacios-González,Berenice,
AU - Zarain-Herzberg,Angel,
AU - Flores-Galicia,Isabel,
AU - Noriega,Lilia G,
AU - Alemán-Escondrillas,Gabriela,
AU - Zariñan,Teresa,
AU - Ulloa-Aguirre,Alfredo,
AU - Torres,Nimbe,
AU - Tovar,Armando R,
Y1 - 2013/09/05/
PY - 2013/05/22/received
PY - 2013/08/02/revised
PY - 2013/08/27/accepted
PY - 2013/9/10/entrez
PY - 2013/9/10/pubmed
PY - 2014/2/22/medline
KW - 007
KW - 5-amino 4-imidazolecarboxamide ribose
KW - 5′-adenosine monophosphate-activated protein kinase
KW - 8-(4-chlorophenylthio)-2-Omethyladenosine-3,5-cAMP
KW - ACC
KW - AICAR
KW - AMPK
KW - CAMKKβ
KW - CPT1
KW - Ca(2+)/calmodulin-dependent protein kinase kinase β
KW - Epac1
KW - FAO
KW - FFA
KW - Fatty acid oxidation
KW - Genistein
KW - HF
KW - JAK2
KW - Janus kinase 2
KW - LEPR
KW - ObR
KW - PDE4
KW - PLC
KW - PPARα
KW - PPARδ
KW - SCD
KW - SIRT1
KW - SP
KW - SREBP1c
KW - Skeletal muscle
KW - Soy protein
KW - UCP3
KW - acetyl CoA carboxylase
KW - cAMP-regulated guanine nucleotide exchange factor
KW - carnitine palmitoyl transferase-1
KW - fatty acid oxidation
KW - free fatty acids
KW - high fat
KW - leptin receptor
KW - peroxisome proliferator activated receptor-δ PGC-1α, PPAR-γ coactivator-1α
KW - peroxisome proliferator-activated receptor-α
KW - phosphodiesterases
KW - phospholipase C
KW - sirtuin 1
KW - soy protein
KW - stearoyl-CoA desaturase-1
KW - sterol regulatory element binding protein-1c
KW - uncoupling carrier protein 3
SP - 132
EP - 40
JF - Biochimica et biophysica acta
JO - Biochim Biophys Acta
VL - 1841
IS - 1
N2 - Obesity is a public health problem that contributes to the development of insulin resistance, which is associated with an excessive accumulation of lipids in skeletal muscle tissue. There is evidence that soy protein can decrease the ectopic accumulation of lipids and improves insulin sensitivity; however, it is unknown whether soy isoflavones, particularly genistein, can stimulate fatty acid oxidation in the skeletal muscle. Thus, we studied the mechanism by which genistein stimulates fatty acid oxidation in the skeletal muscle. We showed that genistein induced the expression of genes of fatty acid oxidation in the skeletal muscle of Zucker fa/fa rats and in leptin receptor (ObR)-silenced C2C12 myotubes through AMPK phosphorylation. Furthermore, the genistein-mediated AMPK phosphorylation occurred via JAK2, which was possibly activated through a mechanism that involved cAMP. Additionally, the genistein-mediated induction of fatty acid oxidation genes involved PGC1α and PPARδ. As a result, we observed that genistein increased fatty acid oxidation in both the control and silenced C2C12 myotubes, as well as a decrease in the RER in mice, suggesting that genistein can be used in strategies to decrease lipid accumulation in the skeletal muscle.
SN - 0006-3002
UR - https://www.unboundmedicine.com/medline/citation/24013029/Genistein_stimulates_fatty_acid_oxidation_in_a_leptin_receptor_independent_manner_through_the_JAK2_mediated_phosphorylation_and_activation_of_AMPK_in_skeletal_muscle_
L2 - https://linkinghub.elsevier.com/retrieve/pii/S1388-1981(13)00189-3
DB - PRIME
DP - Unbound Medicine
ER -