TY - JOUR T1 - Pentylenetetrazole-induced kindling is prevented by prior treatment with cysteamine. AU - Barkai,E, AU - Golan,H, AU - Grossman,Y, AU - Gutnick,M J, PY - 1990/6/21/pubmed PY - 1990/6/21/medline PY - 1990/6/21/entrez SP - 167 EP - 9 JF - European journal of pharmacology JO - Eur J Pharmacol VL - 182 IS - 1 N2 - We have previously demonstrated that in pentylenetetrazole (PTZ)-kindled rats, cysteamine causes prolonged depression of the kindled state. We now report that administration of cysteamine before or during the kindling process prevents attainment of the kindled state. This effect lasts long after cysteamine administration has ceased, suggesting that depletion or somatostatin may not be the only mechanism underlying cysteamine's effect on kindling. The results also support the likelihood that PTZ kindling primarily effects neocortical rather than limbic structures. SN - 0014-2999 UR - https://www.unboundmedicine.com/medline/citation/2401313/Pentylenetetrazole_induced_kindling_is_prevented_by_prior_treatment_with_cysteamine_ DB - PRIME DP - Unbound Medicine ER -