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Vitamin D3 supplementation and upper respiratory tract infections in a randomized, controlled trial.
Clin Infect Dis. 2013 Nov; 57(10):1384-92.CI

Abstract

BACKGROUND

Randomized controlled trials testing the association between vitamin D status and upper respiratory tract infection (URTI) have given mixed results. During a multicenter, randomized controlled trial of colorectal adenoma chemoprevention, we tested whether 1000 IU/day vitamin D(3) supplementation reduced winter episodes and duration of URTI and its composite syndromes, influenza-like illness (ILI; fever and ≥2 of sore throat, cough, muscle ache, or headache) and colds (no fever, and ≥2 of runny nose, nasal congestion, sneezing, sore throat, cough, swollen or tender neck glands).

METHODS

The 2259 trial participants were aged 45-75, in good health, had a history of colorectal adenoma, and had a serum 25-hydroxyvitamin D level ≥12 ng/mL. They were randomized to vitamin D(3) (1000 IU/day), calcium (1200 mg/day), both, or placebo. Of these, 759 participants completed daily symptom diaries. Secondary data included semiannual surveys of all participants.

RESULTS

Among those who completed symptom diaries, supplementation did not significantly reduce winter episodes of URTI (rate ratio [RR], 0.93; 95% confidence interval [CI], .79-1.09) including colds (RR, 0.93; 95% CI, .78-1.10) or ILI (RR, 0.95; 95% CI, .62-1.46), nor did it reduce winter days of illness (RR, 1.13; 95% CI, .90-1.43). There was no significant benefit according to adherence, influenza vaccination, body mass index, or baseline vitamin D status. Semiannual surveys of all participants (N = 2228) identified no benefit of supplementation on ILI (odds ratio [OR], 1.14; 95% CI, .84-1.54) or colds (OR, 1.03; 95% CI, .87-1.23).

CONCLUSIONS

Supplementation with 1000 IU/day vitamin D(3) did not significantly reduce the incidence or duration of URTI in adults with a baseline serum 25-hydroxyvitamin D level ≥12 ng/mL.

Authors+Show Affiliations

Department of Community and Family Medicine, Section of Biostatistics and Epidemiology.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

24014734

Citation

Rees, Judy R., et al. "Vitamin D3 Supplementation and Upper Respiratory Tract Infections in a Randomized, Controlled Trial." Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, vol. 57, no. 10, 2013, pp. 1384-92.
Rees JR, Hendricks K, Barry EL, et al. Vitamin D3 supplementation and upper respiratory tract infections in a randomized, controlled trial. Clin Infect Dis. 2013;57(10):1384-92.
Rees, J. R., Hendricks, K., Barry, E. L., Peacock, J. L., Mott, L. A., Sandler, R. S., Bresalier, R. S., Goodman, M., Bostick, R. M., & Baron, J. A. (2013). Vitamin D3 supplementation and upper respiratory tract infections in a randomized, controlled trial. Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, 57(10), 1384-92. https://doi.org/10.1093/cid/cit549
Rees JR, et al. Vitamin D3 Supplementation and Upper Respiratory Tract Infections in a Randomized, Controlled Trial. Clin Infect Dis. 2013;57(10):1384-92. PubMed PMID: 24014734.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin D3 supplementation and upper respiratory tract infections in a randomized, controlled trial. AU - Rees,Judy R, AU - Hendricks,Kristy, AU - Barry,Elizabeth L, AU - Peacock,Janet L, AU - Mott,Leila A, AU - Sandler,Robert S, AU - Bresalier,Robert S, AU - Goodman,Michael, AU - Bostick,Roberd M, AU - Baron,John A, Y1 - 2013/09/06/ PY - 2013/9/10/entrez PY - 2013/9/10/pubmed PY - 2014/5/23/medline KW - randomized controlled trial KW - upper respiratory tract infection KW - vitamin D SP - 1384 EP - 92 JF - Clinical infectious diseases : an official publication of the Infectious Diseases Society of America JO - Clin. Infect. Dis. VL - 57 IS - 10 N2 - BACKGROUND: Randomized controlled trials testing the association between vitamin D status and upper respiratory tract infection (URTI) have given mixed results. During a multicenter, randomized controlled trial of colorectal adenoma chemoprevention, we tested whether 1000 IU/day vitamin D(3) supplementation reduced winter episodes and duration of URTI and its composite syndromes, influenza-like illness (ILI; fever and ≥2 of sore throat, cough, muscle ache, or headache) and colds (no fever, and ≥2 of runny nose, nasal congestion, sneezing, sore throat, cough, swollen or tender neck glands). METHODS: The 2259 trial participants were aged 45-75, in good health, had a history of colorectal adenoma, and had a serum 25-hydroxyvitamin D level ≥12 ng/mL. They were randomized to vitamin D(3) (1000 IU/day), calcium (1200 mg/day), both, or placebo. Of these, 759 participants completed daily symptom diaries. Secondary data included semiannual surveys of all participants. RESULTS: Among those who completed symptom diaries, supplementation did not significantly reduce winter episodes of URTI (rate ratio [RR], 0.93; 95% confidence interval [CI], .79-1.09) including colds (RR, 0.93; 95% CI, .78-1.10) or ILI (RR, 0.95; 95% CI, .62-1.46), nor did it reduce winter days of illness (RR, 1.13; 95% CI, .90-1.43). There was no significant benefit according to adherence, influenza vaccination, body mass index, or baseline vitamin D status. Semiannual surveys of all participants (N = 2228) identified no benefit of supplementation on ILI (odds ratio [OR], 1.14; 95% CI, .84-1.54) or colds (OR, 1.03; 95% CI, .87-1.23). CONCLUSIONS: Supplementation with 1000 IU/day vitamin D(3) did not significantly reduce the incidence or duration of URTI in adults with a baseline serum 25-hydroxyvitamin D level ≥12 ng/mL. SN - 1537-6591 UR - https://www.unboundmedicine.com/medline/citation/24014734/Vitamin_D3_supplementation_and_upper_respiratory_tract_infections_in_a_randomized_controlled_trial_ L2 - https://academic.oup.com/cid/article-lookup/doi/10.1093/cid/cit549 DB - PRIME DP - Unbound Medicine ER -