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Associations of tobacco use and alcohol drinking with laryngeal and hypopharyngeal cancer risks among men in Karunagappally, Kerala, India -Karunagappally cohort study.

Abstract

BACKGROUND

From among a cohort of 65,553 men aged 30-84 in Karunagappally Taluk, Kerala, India, 52 hypopharyngeal cancer cases and 85 laryngeal cancer cases were identified by the Karunagappally Cancer Registry during the period between 1990 and 2009.

METHODS

We conduct Poisson regression analysis of grouped data, taking into account age and education.

RESULTS

This study showed that the incidence rates of cancers of the hypopharynx and the larynx were strongly related to the number of bidis smoked a day (P<0.001 for both hypopharyngeal and laryngeal cancers) and duration of bidi smoking (P=0.009; P<0.001). Laryngeal cancer risk was significantly increased by bidi smoking (P<0.001), cigarette smoking (P=0.013) and regular alcohol use (P=0.005).

CONCLUSION

The present study, the first cohort study to examine the association of hypopharyngeal and laryngeal cancer incidence rates with bidi smoking in South Asia, clearly showed dose-response relationships between those cancer risks and bidi smoking; larger amounts of bidi smoked a day and longer durations of bidi smoking increased the incidence rates of those cancers. Tobacco chewing was found not related to the risk of hypopharynx or larynx cancer.

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  • Authors+Show Affiliations

    ,

    Regional Cancer Center, Trivandrum, Kerala, India ; Natural Background Radiation Cancer Registry, Karunagappally, Kerala, India.

    , , ,

    Source

    PloS one 8:8 2013 pg e73716

    MeSH

    Adult
    Aged
    Aged, 80 and over
    Alcohol Drinking
    Humans
    Hypopharyngeal Neoplasms
    India
    Laryngeal Neoplasms
    Male
    Middle Aged
    Registries
    Retrospective Studies
    Risk Factors
    Tobacco Use

    Pub Type(s)

    Clinical Trial
    Journal Article
    Multicenter Study
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    24015309

    Citation

    Jayalekshmi, Padmavathy Amma, et al. "Associations of Tobacco Use and Alcohol Drinking With Laryngeal and Hypopharyngeal Cancer Risks Among Men in Karunagappally, Kerala, India -Karunagappally Cohort Study." PloS One, vol. 8, no. 8, 2013, pp. e73716.
    Jayalekshmi PA, Nandakumar A, Akiba S, et al. Associations of tobacco use and alcohol drinking with laryngeal and hypopharyngeal cancer risks among men in Karunagappally, Kerala, India -Karunagappally cohort study. PLoS ONE. 2013;8(8):e73716.
    Jayalekshmi, P. A., Nandakumar, A., Akiba, S., Gangadharan, P., & Koriyama, C. (2013). Associations of tobacco use and alcohol drinking with laryngeal and hypopharyngeal cancer risks among men in Karunagappally, Kerala, India -Karunagappally cohort study. PloS One, 8(8), pp. e73716. doi:10.1371/journal.pone.0073716.
    Jayalekshmi PA, et al. Associations of Tobacco Use and Alcohol Drinking With Laryngeal and Hypopharyngeal Cancer Risks Among Men in Karunagappally, Kerala, India -Karunagappally Cohort Study. PLoS ONE. 2013;8(8):e73716. PubMed PMID: 24015309.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Associations of tobacco use and alcohol drinking with laryngeal and hypopharyngeal cancer risks among men in Karunagappally, Kerala, India -Karunagappally cohort study. AU - Jayalekshmi,Padmavathy Amma, AU - Nandakumar,Athira, AU - Akiba,Suminori, AU - Gangadharan,Paleth, AU - Koriyama,Chihaya, Y1 - 2013/08/28/ PY - 2013/03/01/received PY - 2013/07/23/accepted PY - 2013/9/10/entrez PY - 2013/9/10/pubmed PY - 2014/4/1/medline SP - e73716 EP - e73716 JF - PloS one JO - PLoS ONE VL - 8 IS - 8 N2 - BACKGROUND: From among a cohort of 65,553 men aged 30-84 in Karunagappally Taluk, Kerala, India, 52 hypopharyngeal cancer cases and 85 laryngeal cancer cases were identified by the Karunagappally Cancer Registry during the period between 1990 and 2009. METHODS: We conduct Poisson regression analysis of grouped data, taking into account age and education. RESULTS: This study showed that the incidence rates of cancers of the hypopharynx and the larynx were strongly related to the number of bidis smoked a day (P<0.001 for both hypopharyngeal and laryngeal cancers) and duration of bidi smoking (P=0.009; P<0.001). Laryngeal cancer risk was significantly increased by bidi smoking (P<0.001), cigarette smoking (P=0.013) and regular alcohol use (P=0.005). CONCLUSION: The present study, the first cohort study to examine the association of hypopharyngeal and laryngeal cancer incidence rates with bidi smoking in South Asia, clearly showed dose-response relationships between those cancer risks and bidi smoking; larger amounts of bidi smoked a day and longer durations of bidi smoking increased the incidence rates of those cancers. Tobacco chewing was found not related to the risk of hypopharynx or larynx cancer. SN - 1932-6203 UR - https://www.unboundmedicine.com/medline/citation/24015309/Associations_of_tobacco_use_and_alcohol_drinking_with_laryngeal_and_hypopharyngeal_cancer_risks_among_men_in_Karunagappally_Kerala_India__Karunagappally_cohort_study_ L2 - http://dx.plos.org/10.1371/journal.pone.0073716 DB - PRIME DP - Unbound Medicine ER -