Tags

Type your tag names separated by a space and hit enter

Treatment of acne scars with fractional CO2 laser at 1-month versus 3-month intervals: an intra-individual randomized controlled trial.
Lasers Surg Med. 2014 Feb; 46(2):89-93.LS

Abstract

BACKGROUND

Treatment of acne scars with ablative fractional CO2 laser appears to be an effective and well-tolerated treatment. However, so far the influence of treatment interval has not been evaluated.

OBJECTIVE

To evaluate whether treatment of acne scars with fractional CO2 laser resurfacing at 1-month interval achieves better results with no difference in the occurrence of adverse effects, than treatment given at 3-months interval.

METHODS

Patients (n = 13) with symmetrical atrophic acne scars on right and left sides of the mid-face and lower-face were randomized to two fractional CO2 laser treatments at 1-month versus 3-month intervals. Blinded on-site evaluations were performed 1 and 6 months after the last treatment on 10-point scales. Endpoints were scar atrophy, patient satisfaction, and adverse effects.

RESULTS

Pre-operatively, acne scars were moderately atrophic (5.86 ± 1.87). After treatment acne scars appeared with less atrophy on both treated sides 1 month postoperatively (1-month interval 1.96 ± 1.23, P < 0.0001; 3-months interval 1.82 ± 1.08, P = 0.0006) and 6 months postoperatively (1-month interval 1.56 ± 1.24, P = 0.0021; 3-months interval 1.33 ± 1.66, P = 0.0002). The treatment interval did not influence the improvement of scar atrophy at any time postoperatively (P = 0.81). Patients were moderately and equally satisfied with the treatment result on facial sides (P = 0.93). Postoperative adverse effects were minor and not influenced by the treatment interval.

CONCLUSIONS

Fractional CO2 laser resurfacing improves atrophic acne scars and a treatment interval of either 1-month or 3-months does not seem to influence the improvement of scar atrophy nor the occurrence of postoperative adverse effects.

Authors+Show Affiliations

Department of Dermatology, Aarhus University Hospital, Aarhus, Denmark.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24018777

Citation

Bjørn, Marie, et al. "Treatment of Acne Scars With Fractional CO2 Laser at 1-month Versus 3-month Intervals: an Intra-individual Randomized Controlled Trial." Lasers in Surgery and Medicine, vol. 46, no. 2, 2014, pp. 89-93.
Bjørn M, Stausbøl-Grøn B, Braae Olesen A, et al. Treatment of acne scars with fractional CO2 laser at 1-month versus 3-month intervals: an intra-individual randomized controlled trial. Lasers Surg Med. 2014;46(2):89-93.
Bjørn, M., Stausbøl-Grøn, B., Braae Olesen, A., & Hedelund, L. (2014). Treatment of acne scars with fractional CO2 laser at 1-month versus 3-month intervals: an intra-individual randomized controlled trial. Lasers in Surgery and Medicine, 46(2), 89-93. https://doi.org/10.1002/lsm.22165
Bjørn M, et al. Treatment of Acne Scars With Fractional CO2 Laser at 1-month Versus 3-month Intervals: an Intra-individual Randomized Controlled Trial. Lasers Surg Med. 2014;46(2):89-93. PubMed PMID: 24018777.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Treatment of acne scars with fractional CO2 laser at 1-month versus 3-month intervals: an intra-individual randomized controlled trial. AU - Bjørn,Marie, AU - Stausbøl-Grøn,Birgitte, AU - Braae Olesen,Anne, AU - Hedelund,Lene, Y1 - 2013/09/09/ PY - 2013/07/19/accepted PY - 2013/9/11/entrez PY - 2013/9/11/pubmed PY - 2014/10/17/medline KW - adverse effects KW - patient satisfaction KW - pigmentation KW - scar atrophy KW - skin redness SP - 89 EP - 93 JF - Lasers in surgery and medicine JO - Lasers Surg Med VL - 46 IS - 2 N2 - BACKGROUND: Treatment of acne scars with ablative fractional CO2 laser appears to be an effective and well-tolerated treatment. However, so far the influence of treatment interval has not been evaluated. OBJECTIVE: To evaluate whether treatment of acne scars with fractional CO2 laser resurfacing at 1-month interval achieves better results with no difference in the occurrence of adverse effects, than treatment given at 3-months interval. METHODS: Patients (n = 13) with symmetrical atrophic acne scars on right and left sides of the mid-face and lower-face were randomized to two fractional CO2 laser treatments at 1-month versus 3-month intervals. Blinded on-site evaluations were performed 1 and 6 months after the last treatment on 10-point scales. Endpoints were scar atrophy, patient satisfaction, and adverse effects. RESULTS: Pre-operatively, acne scars were moderately atrophic (5.86 ± 1.87). After treatment acne scars appeared with less atrophy on both treated sides 1 month postoperatively (1-month interval 1.96 ± 1.23, P < 0.0001; 3-months interval 1.82 ± 1.08, P = 0.0006) and 6 months postoperatively (1-month interval 1.56 ± 1.24, P = 0.0021; 3-months interval 1.33 ± 1.66, P = 0.0002). The treatment interval did not influence the improvement of scar atrophy at any time postoperatively (P = 0.81). Patients were moderately and equally satisfied with the treatment result on facial sides (P = 0.93). Postoperative adverse effects were minor and not influenced by the treatment interval. CONCLUSIONS: Fractional CO2 laser resurfacing improves atrophic acne scars and a treatment interval of either 1-month or 3-months does not seem to influence the improvement of scar atrophy nor the occurrence of postoperative adverse effects. SN - 1096-9101 UR - https://www.unboundmedicine.com/medline/citation/24018777/Treatment_of_acne_scars_with_fractional_CO2_laser_at_1_month_versus_3_month_intervals:_an_intra_individual_randomized_controlled_trial_ L2 - https://doi.org/10.1002/lsm.22165 DB - PRIME DP - Unbound Medicine ER -