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Vitamin D and bone health outcomes in older age.
Proc Nutr Soc. 2013 Nov; 72(4):372-80.PN

Abstract

The aim of this review is to summarise the evidence linking vitamin D to bone health outcomes in older adults. A plethora of scientific evidence globally suggests that large proportions of people have vitamin D deficiency and are not meeting recommended intakes. Older adults are at particular risk of the consequences of vitamin D deficiency owing to a combination of physiological and behavioural factors. Epidemiological studies show that low vitamin D status is associated with a variety of negative skeletal consequences in older adults including osteomalacia, reduced bone mineral density, impaired Ca absorption and secondary hyperparathyroidism. There seems to be inconsistent evidence for a protective role of vitamin D supplementation alone on bone mass. However, it is generally accepted that vitamin D (17·5 μg/d) in combination with Ca (1200 mg/d) reduces bone loss among older white subjects. Evidence for a benefit of vitamin D supplementation alone on reducing fracture risk is varied. According to a recent Agency for Healthcare Research and Quality review in the USA the evidence base shows mixed results for a beneficial effect of vitamin D on decreasing overall fracture risk. Limitations such as poor compliance with treatment, incomplete assessment of vitamin D status and large drop-out rates however, have been highlighted within some studies. In conclusion, it is generally accepted that vitamin D in combination with Ca reduces the risk of non-vertebral fractures particularly those in institutional care. The lack of data on vitamin D and bone health outcomes in certain population groups such as diverse racial groups warrants attention.

Authors+Show Affiliations

School of Agriculture, Food and Rural Development and Human Nutrition Research Centre, Newcastle University, Newcastle-Upon-Tyne NE1 7RU, UK.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

24020640

Citation

Hill, Tom R., et al. "Vitamin D and Bone Health Outcomes in Older Age." The Proceedings of the Nutrition Society, vol. 72, no. 4, 2013, pp. 372-80.
Hill TR, Aspray TJ, Francis RM. Vitamin D and bone health outcomes in older age. Proc Nutr Soc. 2013;72(4):372-80.
Hill, T. R., Aspray, T. J., & Francis, R. M. (2013). Vitamin D and bone health outcomes in older age. The Proceedings of the Nutrition Society, 72(4), 372-80. https://doi.org/10.1017/S0029665113002036
Hill TR, Aspray TJ, Francis RM. Vitamin D and Bone Health Outcomes in Older Age. Proc Nutr Soc. 2013;72(4):372-80. PubMed PMID: 24020640.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin D and bone health outcomes in older age. AU - Hill,Tom R, AU - Aspray,Terence J, AU - Francis,Roger M, Y1 - 2013/09/11/ PY - 2013/9/12/entrez PY - 2013/9/12/pubmed PY - 2014/6/7/medline SP - 372 EP - 80 JF - The Proceedings of the Nutrition Society JO - Proc Nutr Soc VL - 72 IS - 4 N2 - The aim of this review is to summarise the evidence linking vitamin D to bone health outcomes in older adults. A plethora of scientific evidence globally suggests that large proportions of people have vitamin D deficiency and are not meeting recommended intakes. Older adults are at particular risk of the consequences of vitamin D deficiency owing to a combination of physiological and behavioural factors. Epidemiological studies show that low vitamin D status is associated with a variety of negative skeletal consequences in older adults including osteomalacia, reduced bone mineral density, impaired Ca absorption and secondary hyperparathyroidism. There seems to be inconsistent evidence for a protective role of vitamin D supplementation alone on bone mass. However, it is generally accepted that vitamin D (17·5 μg/d) in combination with Ca (1200 mg/d) reduces bone loss among older white subjects. Evidence for a benefit of vitamin D supplementation alone on reducing fracture risk is varied. According to a recent Agency for Healthcare Research and Quality review in the USA the evidence base shows mixed results for a beneficial effect of vitamin D on decreasing overall fracture risk. Limitations such as poor compliance with treatment, incomplete assessment of vitamin D status and large drop-out rates however, have been highlighted within some studies. In conclusion, it is generally accepted that vitamin D in combination with Ca reduces the risk of non-vertebral fractures particularly those in institutional care. The lack of data on vitamin D and bone health outcomes in certain population groups such as diverse racial groups warrants attention. SN - 1475-2719 UR - https://www.unboundmedicine.com/medline/citation/24020640/Vitamin_D_and_bone_health_outcomes_in_older_age_ DB - PRIME DP - Unbound Medicine ER -