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Intake of coffee, caffeine and other methylxanthines and risk of Type I vs Type II endometrial cancer.
Br J Cancer 2013; 109(7):1908-13BJ

Abstract

BACKGROUND

Coffee and other sources of methylxanthines and risk of Type I vs Type II endometrial cancer (EC) have not been evaluated previously.

METHODS

Prospective cohort of 23,356 postmenopausal women with 471 Type I and 71 Type II EC cases.

RESULTS

Type I EC was statistically significantly associated with caffeinated (relative risk (RR)=0.65 for 4+ cups per day vs ≤1 cup per month: 95% confidence interval (CI): 0.47-0.89) but not decaffeinated (RR=0.76; 95% CI: 0.50-1.15) coffee intake; there were no associations with tea, cola or chocolate, or for Type II EC. The inverse association with caffeinated coffee intake was specific to women with a body mass index 30+ kg m(-2) (RR=0.56; 95% CI: 0.36-0.89).

CONCLUSION

Coffee may protect against Type I EC in obese postmenopausal women.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, Division of Gynecologic Surgery, Rochester, MN 55901, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24022184

Citation

Uccella, S, et al. "Intake of Coffee, Caffeine and Other Methylxanthines and Risk of Type I Vs Type II Endometrial Cancer." British Journal of Cancer, vol. 109, no. 7, 2013, pp. 1908-13.
Uccella S, Mariani A, Wang AH, et al. Intake of coffee, caffeine and other methylxanthines and risk of Type I vs Type II endometrial cancer. Br J Cancer. 2013;109(7):1908-13.
Uccella, S., Mariani, A., Wang, A. H., Vierkant, R. A., Cliby, W. A., Robien, K., ... Cerhan, J. R. (2013). Intake of coffee, caffeine and other methylxanthines and risk of Type I vs Type II endometrial cancer. British Journal of Cancer, 109(7), pp. 1908-13. doi:10.1038/bjc.2013.540.
Uccella S, et al. Intake of Coffee, Caffeine and Other Methylxanthines and Risk of Type I Vs Type II Endometrial Cancer. Br J Cancer. 2013 Oct 1;109(7):1908-13. PubMed PMID: 24022184.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Intake of coffee, caffeine and other methylxanthines and risk of Type I vs Type II endometrial cancer. AU - Uccella,S, AU - Mariani,A, AU - Wang,A H, AU - Vierkant,R A, AU - Cliby,W A, AU - Robien,K, AU - Anderson,K E, AU - Cerhan,J R, Y1 - 2013/09/10/ PY - 2013/04/16/received PY - 2013/07/25/revised PY - 2013/08/13/accepted PY - 2013/9/12/entrez PY - 2013/9/12/pubmed PY - 2013/12/16/medline SP - 1908 EP - 13 JF - British journal of cancer JO - Br. J. Cancer VL - 109 IS - 7 N2 - BACKGROUND: Coffee and other sources of methylxanthines and risk of Type I vs Type II endometrial cancer (EC) have not been evaluated previously. METHODS: Prospective cohort of 23,356 postmenopausal women with 471 Type I and 71 Type II EC cases. RESULTS: Type I EC was statistically significantly associated with caffeinated (relative risk (RR)=0.65 for 4+ cups per day vs ≤1 cup per month: 95% confidence interval (CI): 0.47-0.89) but not decaffeinated (RR=0.76; 95% CI: 0.50-1.15) coffee intake; there were no associations with tea, cola or chocolate, or for Type II EC. The inverse association with caffeinated coffee intake was specific to women with a body mass index 30+ kg m(-2) (RR=0.56; 95% CI: 0.36-0.89). CONCLUSION: Coffee may protect against Type I EC in obese postmenopausal women. SN - 1532-1827 UR - https://www.unboundmedicine.com/medline/citation/24022184/Intake_of_coffee_caffeine_and_other_methylxanthines_and_risk_of_Type_I_vs_Type_II_endometrial_cancer_ L2 - http://dx.doi.org/10.1038/bjc.2013.540 DB - PRIME DP - Unbound Medicine ER -