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Lack of association of apolipoprotein E (Apo E) ε2/ε3/ε4 polymorphisms with primary open-angle glaucoma: a meta-analysis from 1916 cases and 1756 controls.
PLoS One. 2013; 8(9):e72644.Plos

Abstract

BACKGROUND

A number of case-control studies were conducted to investigate the association of apolipoprotein E (Apo E) polymorphisms with primary open angle glaucoma (POAG). But the results remain controversial. This meta-analysis aims to comprehensively evaluate the relationship between a common ε2/ε3/ε4 polymorphism in Apo E gene on the risk of POAG.

METHOD

A comprehensive literature search for studies published up to April 2013 was performed. Summary odds ratios (ORs) and 95% confidence intervals (CI) were calculated employing random-effects models irrespective of between-study heterogeneity. Publication bias of literatures was evaluated using funnel plots and Egger's test.

RESULTS

A total of 12 studies including 1916 cases and 1756 controls meeting the predefined criteria were involved in this meta-analysis. Overall, the Apo E ε2 allele and ε4 allele were not associated with POAG, compared with those carrying ε3 allele, with ORs of 0.98 (95% CI, 0.79 to 1.23; P=0.872) and 1.05 (95% CI, 0.78 to 1.41; P=0.743), respectively. Genotypic analysis also found no significant association between the ε4 carriers (ε3/ε4+ε4/ε4), ε2 carriers (ε2/ε3+ε2/ε2) and POAG, compared with participants with Apo E ε3/3, with ORs of 0.91 (95% CI, 0.66 to 1.25; P=0.543) and 1.08 (95% CI, 0.74 to 1.57; P=0.694), respectively. In the subgroup analysis by ethnicity, source of controls, genotyping methods, Hardy-Weinberg equilibrium or not, or type of the POAG, still no obvious associations were found.

CONCLUSIONS

This meta-analysis suggests that Apo E ε2/ε3/ε4 polymorphisms may not be associated with the risk of POAG. However, well-designed studies with larger sample size and more ethnic groups are required to further validate the results.

Authors+Show Affiliations

Zhongshan Ophthalmic Center, State Key Laboratory of Ophthalmology, Sun Yat-Sen University, Guangzhou, People's Republic of China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24023758

Citation

Wang, Wei, et al. "Lack of Association of Apolipoprotein E (Apo E) Ε2/ε3/ε4 Polymorphisms With Primary Open-angle Glaucoma: a Meta-analysis From 1916 Cases and 1756 Controls." PloS One, vol. 8, no. 9, 2013, pp. e72644.
Wang W, Zhou M, Huang W, et al. Lack of association of apolipoprotein E (Apo E) ε2/ε3/ε4 polymorphisms with primary open-angle glaucoma: a meta-analysis from 1916 cases and 1756 controls. PLoS One. 2013;8(9):e72644.
Wang, W., Zhou, M., Huang, W., Chen, S., & Zhang, X. (2013). Lack of association of apolipoprotein E (Apo E) ε2/ε3/ε4 polymorphisms with primary open-angle glaucoma: a meta-analysis from 1916 cases and 1756 controls. PloS One, 8(9), e72644. https://doi.org/10.1371/journal.pone.0072644
Wang W, et al. Lack of Association of Apolipoprotein E (Apo E) Ε2/ε3/ε4 Polymorphisms With Primary Open-angle Glaucoma: a Meta-analysis From 1916 Cases and 1756 Controls. PLoS One. 2013;8(9):e72644. PubMed PMID: 24023758.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lack of association of apolipoprotein E (Apo E) ε2/ε3/ε4 polymorphisms with primary open-angle glaucoma: a meta-analysis from 1916 cases and 1756 controls. AU - Wang,Wei, AU - Zhou,Minwen, AU - Huang,Wenbin, AU - Chen,Shida, AU - Zhang,Xiulan, Y1 - 2013/09/02/ PY - 2013/03/17/received PY - 2013/07/12/accepted PY - 2013/9/12/entrez PY - 2013/9/12/pubmed PY - 2014/4/3/medline SP - e72644 EP - e72644 JF - PloS one JO - PLoS One VL - 8 IS - 9 N2 - BACKGROUND: A number of case-control studies were conducted to investigate the association of apolipoprotein E (Apo E) polymorphisms with primary open angle glaucoma (POAG). But the results remain controversial. This meta-analysis aims to comprehensively evaluate the relationship between a common ε2/ε3/ε4 polymorphism in Apo E gene on the risk of POAG. METHOD: A comprehensive literature search for studies published up to April 2013 was performed. Summary odds ratios (ORs) and 95% confidence intervals (CI) were calculated employing random-effects models irrespective of between-study heterogeneity. Publication bias of literatures was evaluated using funnel plots and Egger's test. RESULTS: A total of 12 studies including 1916 cases and 1756 controls meeting the predefined criteria were involved in this meta-analysis. Overall, the Apo E ε2 allele and ε4 allele were not associated with POAG, compared with those carrying ε3 allele, with ORs of 0.98 (95% CI, 0.79 to 1.23; P=0.872) and 1.05 (95% CI, 0.78 to 1.41; P=0.743), respectively. Genotypic analysis also found no significant association between the ε4 carriers (ε3/ε4+ε4/ε4), ε2 carriers (ε2/ε3+ε2/ε2) and POAG, compared with participants with Apo E ε3/3, with ORs of 0.91 (95% CI, 0.66 to 1.25; P=0.543) and 1.08 (95% CI, 0.74 to 1.57; P=0.694), respectively. In the subgroup analysis by ethnicity, source of controls, genotyping methods, Hardy-Weinberg equilibrium or not, or type of the POAG, still no obvious associations were found. CONCLUSIONS: This meta-analysis suggests that Apo E ε2/ε3/ε4 polymorphisms may not be associated with the risk of POAG. However, well-designed studies with larger sample size and more ethnic groups are required to further validate the results. SN - 1932-6203 UR - https://www.unboundmedicine.com/medline/citation/24023758/Lack_of_association_of_apolipoprotein_E__Apo_E__ε2/ε3/ε4_polymorphisms_with_primary_open_angle_glaucoma:_a_meta_analysis_from_1916_cases_and_1756_controls_ L2 - https://dx.plos.org/10.1371/journal.pone.0072644 DB - PRIME DP - Unbound Medicine ER -