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Duration of untreated psychosis in adolescents: ethnic differences and clinical profiles.
Schizophr Res. 2013 Nov; 150(2-3):526-32.SR

Abstract

BACKGROUND

Duration of Untreated Psychosis (DUP) is an important measure associated with outcome of psychosis. This first study in the UK compared DUP between adolescent and adult-onset individuals and explored whether the adolescent-onset group showed variations in DUP that could be accounted for by sociodemographic and selected risk factors.

METHODS

This naturalistic cohort study included 940 new first-episode psychosis cases aged 14-35years (136 adolescent-onset versus 804 adult-onset psychotic individuals) referred to nine Early Intervention Services for Psychosis in London (2003-2009). Sociodemographic characteristics, age of onset, family history of mental illness, duration of untreated psychosis, suicidality and substance use information were collected at entry to the services.

RESULTS

Adolescents presented with significantly greater median DUP (179days) than adults (81days, p=0.005). Large differences in DUP were found amongst adolescent ethnic groups (median DUP: White: 454days; Black: 103days; Asian and mixed: 28.5days). In addition, younger age of onset and higher lifetime cannabis use were associated with longer treatment delay amongst adolescents.

CONCLUSIONS

This study of DUP in adolescent-onset psychosis found it to be approximately twice the length of DUP amongst adults. For the adolescent White sub-group, DUP was far greater than the UK Department of Health target (<3months). Both the high rates of lifetime cannabis use and the lower age of onset might explain the long DUP in this ethnic group. Physicians need to be particularly vigilant about identifying and managing early psychosis in adolescents.

Authors+Show Affiliations

Academic Unit of Child and Adolescent Psychiatry, Division of Brain Sciences, Imperial College London, UK. Electronic address: m.dominquez-barrera@imperial.ac.uk.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24025696

Citation

Dominguez, Maria-de-Gracia, et al. "Duration of Untreated Psychosis in Adolescents: Ethnic Differences and Clinical Profiles." Schizophrenia Research, vol. 150, no. 2-3, 2013, pp. 526-32.
Dominguez MD, Fisher HL, Major B, et al. Duration of untreated psychosis in adolescents: ethnic differences and clinical profiles. Schizophr Res. 2013;150(2-3):526-32.
Dominguez, M. D., Fisher, H. L., Major, B., Chisholm, B., Rahaman, N., Joyce, J., Woolley, J., Lawrence, J., Hinton, M., Marlowe, K., Aitchison, K., Johnson, S., & Hodes, M. (2013). Duration of untreated psychosis in adolescents: ethnic differences and clinical profiles. Schizophrenia Research, 150(2-3), 526-32. https://doi.org/10.1016/j.schres.2013.08.018
Dominguez MD, et al. Duration of Untreated Psychosis in Adolescents: Ethnic Differences and Clinical Profiles. Schizophr Res. 2013;150(2-3):526-32. PubMed PMID: 24025696.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Duration of untreated psychosis in adolescents: ethnic differences and clinical profiles. AU - Dominguez,Maria-de-Gracia, AU - Fisher,Helen L, AU - Major,Barnaby, AU - Chisholm,Brock, AU - Rahaman,Nikola, AU - Joyce,John, AU - Woolley,James, AU - Lawrence,Jo, AU - Hinton,Mark, AU - Marlowe,Karl, AU - Aitchison,Katherine, AU - Johnson,Sonia, AU - Hodes,Matthew, Y1 - 2013/09/08/ PY - 2013/03/27/received PY - 2013/07/25/revised PY - 2013/08/14/accepted PY - 2013/9/13/entrez PY - 2013/9/13/pubmed PY - 2014/6/21/medline KW - Adolescence KW - Age of onset KW - Cannabis KW - Duration of untreated psychosis KW - Ethnicity KW - First episode psychosis SP - 526 EP - 32 JF - Schizophrenia research JO - Schizophr Res VL - 150 IS - 2-3 N2 - BACKGROUND: Duration of Untreated Psychosis (DUP) is an important measure associated with outcome of psychosis. This first study in the UK compared DUP between adolescent and adult-onset individuals and explored whether the adolescent-onset group showed variations in DUP that could be accounted for by sociodemographic and selected risk factors. METHODS: This naturalistic cohort study included 940 new first-episode psychosis cases aged 14-35years (136 adolescent-onset versus 804 adult-onset psychotic individuals) referred to nine Early Intervention Services for Psychosis in London (2003-2009). Sociodemographic characteristics, age of onset, family history of mental illness, duration of untreated psychosis, suicidality and substance use information were collected at entry to the services. RESULTS: Adolescents presented with significantly greater median DUP (179days) than adults (81days, p=0.005). Large differences in DUP were found amongst adolescent ethnic groups (median DUP: White: 454days; Black: 103days; Asian and mixed: 28.5days). In addition, younger age of onset and higher lifetime cannabis use were associated with longer treatment delay amongst adolescents. CONCLUSIONS: This study of DUP in adolescent-onset psychosis found it to be approximately twice the length of DUP amongst adults. For the adolescent White sub-group, DUP was far greater than the UK Department of Health target (<3months). Both the high rates of lifetime cannabis use and the lower age of onset might explain the long DUP in this ethnic group. Physicians need to be particularly vigilant about identifying and managing early psychosis in adolescents. SN - 1573-2509 UR - https://www.unboundmedicine.com/medline/citation/24025696/Duration_of_untreated_psychosis_in_adolescents:_ethnic_differences_and_clinical_profiles_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0920-9964(13)00454-4 DB - PRIME DP - Unbound Medicine ER -