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Tea polyphenols as novel and potent inhibitory substances against renin activity.
J Agric Food Chem 2013; 61(40):9697-704JA

Abstract

Renin inhibitory activities of three tea products were investigated for the first time in this work. Water extracts from fermented oolong and black tea showed strong renin inhibitory activities. By the means of ultrafiltration, gradient high performance liquid chromatography and spectroscopic analysis, four active compounds were separated from aqueous black tea extract and identified as theasinensin B, theasinensin C, strictinin, and a hexose sulfate with a galloyl moiety, which had IC50 values of 19.33, 40.21, 311.09, and 50.16 μM against renin activity, respectively. Further detection indicated that the potent inhibitor theasinensin B was present only in black tea, and that monomeric catechins did not contribute significantly to the renin inhibitory activities of tea products. These results revealed novel and potent tea-derived renin inhibitors and suggested another potential pathway for tea consumption to control hypertension.

Authors+Show Affiliations

National Food Research Institute, National Agricultural and Food Research Organization , 2-1-12 Kannondai, Tsukuba, Ibaraki 305-8642, Japan.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24028635

Citation

Li, Fengjuan, et al. "Tea Polyphenols as Novel and Potent Inhibitory Substances Against Renin Activity." Journal of Agricultural and Food Chemistry, vol. 61, no. 40, 2013, pp. 9697-704.
Li F, Ohnishi-Kameyama M, Takahashi Y, et al. Tea polyphenols as novel and potent inhibitory substances against renin activity. J Agric Food Chem. 2013;61(40):9697-704.
Li, F., Ohnishi-Kameyama, M., Takahashi, Y., & Yamaki, K. (2013). Tea polyphenols as novel and potent inhibitory substances against renin activity. Journal of Agricultural and Food Chemistry, 61(40), pp. 9697-704. doi:10.1021/jf403710b.
Li F, et al. Tea Polyphenols as Novel and Potent Inhibitory Substances Against Renin Activity. J Agric Food Chem. 2013 Oct 9;61(40):9697-704. PubMed PMID: 24028635.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Tea polyphenols as novel and potent inhibitory substances against renin activity. AU - Li,Fengjuan, AU - Ohnishi-Kameyama,Mayumi, AU - Takahashi,Yoko, AU - Yamaki,Kohji, Y1 - 2013/09/30/ PY - 2013/9/14/entrez PY - 2013/9/14/pubmed PY - 2014/7/16/medline SP - 9697 EP - 704 JF - Journal of agricultural and food chemistry JO - J. Agric. Food Chem. VL - 61 IS - 40 N2 - Renin inhibitory activities of three tea products were investigated for the first time in this work. Water extracts from fermented oolong and black tea showed strong renin inhibitory activities. By the means of ultrafiltration, gradient high performance liquid chromatography and spectroscopic analysis, four active compounds were separated from aqueous black tea extract and identified as theasinensin B, theasinensin C, strictinin, and a hexose sulfate with a galloyl moiety, which had IC50 values of 19.33, 40.21, 311.09, and 50.16 μM against renin activity, respectively. Further detection indicated that the potent inhibitor theasinensin B was present only in black tea, and that monomeric catechins did not contribute significantly to the renin inhibitory activities of tea products. These results revealed novel and potent tea-derived renin inhibitors and suggested another potential pathway for tea consumption to control hypertension. SN - 1520-5118 UR - https://www.unboundmedicine.com/medline/citation/24028635/Tea_polyphenols_as_novel_and_potent_inhibitory_substances_against_renin_activity_ L2 - https://dx.doi.org/10.1021/jf403710b DB - PRIME DP - Unbound Medicine ER -