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[Clinicopathological significance of abnormal metabolism of polyunsaturated fatty acids in colorectal cancer tissue].
Zhonghua Yi Xue Za Zhi. 2013 May 28; 93(20):1550-4.ZY

Abstract

OBJECTIVE

To explore the relationship between different tissue levels of polyunsaturated fatty acid (PUFA) and the clinicopathologic parameters in colorectal carcinoma (CRC) and evaluate their prognostic significance.

METHODS

Fresh frozen malignant tissue was obtained from 82 colorectal cancer patients at PLA general Hospital from December 2010 to March 2011. The immunohistochemical results were obtained for vascular endothelial growth factor (VEGF), P53 and Ki-67. The relationship between the PUFA level and such clinicopathological profiles as age, gender, location, differentiation degree, TNM (tumor, node and metastasis) stage, VEGF, Ki-67 and P53 was analyzed.

RESULTS

Tissue level of arachidonic acid (AA) in patients aged over 60 years (n = 44) was significantly lower than those under 60 years (n = 38) (0.12% ± 0.06% vs 0.17% ± 0.09%, P = 0.045). In patients with tumor size < 5 cm (n = 42), tissue level of EPA was significantly higher (0.29% ± 0.13% vs 0.20% ± 0.14%, P = 0.030) while ω-6/ω-3 PUFA lower (10.8 ± 2.6 vs 13.2 ± 6.4, P = 0.031). Significant statistical difference existed in tissue level of LA, AA/ω-3 PUFA in different differentiation degrees(P = 0.013, 0.027). Tissue level of linoleic acid(LA) in poorly differentiated tumor was the highest (19.9% ± 6.3%) while AA/ω-3 PUFA the lowest (4.1 ± 2.0, P < 0.05). Tissue level of LA was higher in VEGF-positive tumors than those in VEGF-negative counterparts(16.2% ± 3.7% vs 13.9% ± 2.7%, P = 0.009) while the ratios AA/ω-3 PUFA, AA/ω-6 PUFA, AA/LA in VEGF-positive tumors were lower than those in VEGF-negative counterparts (5.0 ± 1.8 vs 6.7 ± 3.3, 0.30 ± 0.09 vs 0.34 ± 0.09, 0.50 ± 0.21 vs 0.61 ± 0.21, P = 0.004, 0.038, 0.030) . In Ki-67 negative LA was highest (22.5% ± 10.1%, P = 0.048). No significant differences existed in the level of PUFA among the gender, the clinicopathological stage, lymph node metastasis and groups with differential expressions of P53 (all P > 0.05).

CONCLUSIONS

The tissue levels of PUFA are somewhat correlated with the clinicopathologic parameters of CRC. And the prognosis of CRC may be evaluated through the test of PUFA.

Authors+Show Affiliations

Department of General Surgery, Chinese People's Liberation Army General Hospital, Beijing, China.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

24028721

Citation

Yang, Kai, et al. "[Clinicopathological Significance of Abnormal Metabolism of Polyunsaturated Fatty Acids in Colorectal Cancer Tissue]." Zhonghua Yi Xue Za Zhi, vol. 93, no. 20, 2013, pp. 1550-4.
Yang K, Tian W, Zhao P, et al. [Clinicopathological significance of abnormal metabolism of polyunsaturated fatty acids in colorectal cancer tissue]. Zhonghua Yi Xue Za Zhi. 2013;93(20):1550-4.
Yang, K., Tian, W., Zhao, P., & Li, H. (2013). [Clinicopathological significance of abnormal metabolism of polyunsaturated fatty acids in colorectal cancer tissue]. Zhonghua Yi Xue Za Zhi, 93(20), 1550-4.
Yang K, et al. [Clinicopathological Significance of Abnormal Metabolism of Polyunsaturated Fatty Acids in Colorectal Cancer Tissue]. Zhonghua Yi Xue Za Zhi. 2013 May 28;93(20):1550-4. PubMed PMID: 24028721.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Clinicopathological significance of abnormal metabolism of polyunsaturated fatty acids in colorectal cancer tissue]. AU - Yang,Kai, AU - Tian,Wen, AU - Zhao,Po, AU - Li,Hong, PY - 2013/9/14/entrez PY - 2013/9/14/pubmed PY - 2014/3/13/medline SP - 1550 EP - 4 JF - Zhonghua yi xue za zhi JO - Zhonghua Yi Xue Za Zhi VL - 93 IS - 20 N2 - OBJECTIVE: To explore the relationship between different tissue levels of polyunsaturated fatty acid (PUFA) and the clinicopathologic parameters in colorectal carcinoma (CRC) and evaluate their prognostic significance. METHODS: Fresh frozen malignant tissue was obtained from 82 colorectal cancer patients at PLA general Hospital from December 2010 to March 2011. The immunohistochemical results were obtained for vascular endothelial growth factor (VEGF), P53 and Ki-67. The relationship between the PUFA level and such clinicopathological profiles as age, gender, location, differentiation degree, TNM (tumor, node and metastasis) stage, VEGF, Ki-67 and P53 was analyzed. RESULTS: Tissue level of arachidonic acid (AA) in patients aged over 60 years (n = 44) was significantly lower than those under 60 years (n = 38) (0.12% ± 0.06% vs 0.17% ± 0.09%, P = 0.045). In patients with tumor size < 5 cm (n = 42), tissue level of EPA was significantly higher (0.29% ± 0.13% vs 0.20% ± 0.14%, P = 0.030) while ω-6/ω-3 PUFA lower (10.8 ± 2.6 vs 13.2 ± 6.4, P = 0.031). Significant statistical difference existed in tissue level of LA, AA/ω-3 PUFA in different differentiation degrees(P = 0.013, 0.027). Tissue level of linoleic acid(LA) in poorly differentiated tumor was the highest (19.9% ± 6.3%) while AA/ω-3 PUFA the lowest (4.1 ± 2.0, P < 0.05). Tissue level of LA was higher in VEGF-positive tumors than those in VEGF-negative counterparts(16.2% ± 3.7% vs 13.9% ± 2.7%, P = 0.009) while the ratios AA/ω-3 PUFA, AA/ω-6 PUFA, AA/LA in VEGF-positive tumors were lower than those in VEGF-negative counterparts (5.0 ± 1.8 vs 6.7 ± 3.3, 0.30 ± 0.09 vs 0.34 ± 0.09, 0.50 ± 0.21 vs 0.61 ± 0.21, P = 0.004, 0.038, 0.030) . In Ki-67 negative LA was highest (22.5% ± 10.1%, P = 0.048). No significant differences existed in the level of PUFA among the gender, the clinicopathological stage, lymph node metastasis and groups with differential expressions of P53 (all P > 0.05). CONCLUSIONS: The tissue levels of PUFA are somewhat correlated with the clinicopathologic parameters of CRC. And the prognosis of CRC may be evaluated through the test of PUFA. SN - 0376-2491 UR - https://www.unboundmedicine.com/medline/citation/24028721/[Clinicopathological_significance_of_abnormal_metabolism_of_polyunsaturated_fatty_acids_in_colorectal_cancer_tissue]_ L2 - http://journal.yiigle.com/LinkIn.do?linkin_type=pubmed&amp;issn=0376-2491&amp;year=2013&amp;vol=93&amp;issue=20&amp;fpage=1550 DB - PRIME DP - Unbound Medicine ER -