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Recent advances in understanding the anti-diabetic actions of dietary flavonoids.
J Nutr Biochem. 2013 Nov; 24(11):1777-89.JN

Abstract

Flavonoids are polyphenolic compounds that are abundant in fruits and vegetables, and increasing evidence demonstrates a positive relationship between consumption of flavonoid-rich foods and disease prevention. Epidemiological, in vitro and animal studies support the beneficial effects of dietary flavonoids on glucose and lipid homeostasis. It is encouraging that the beneficial effects of some flavonoids are at physiological concentrations and comparable to clinically-used anti-diabetic drugs; however, clinical research in this field and studies on the anti-diabetic effects of flavonoid metabolites are limited. Flavonoids act on various molecular targets and regulate different signaling pathways in pancreatic β-cells, hepatocytes, adipocytes and skeletal myofibers. Flavonoids may exert beneficial effects in diabetes by (i) enhancing insulin secretion and reducing apoptosis and promoting proliferation of pancreatic β-cells; (ii) improving hyperglycemia through regulation of glucose metabolism in hepatocytes; (iii) reducing insulin resistance, inflammation and oxidative stress in muscle and fat and (iv) increasing glucose uptake in skeletal muscle and white adipose tissue. This review highlights recent findings on the anti-diabetic effects of dietary flavonoids, including flavan-3-ols, flavanones, flavonols, anthocyanidins, flavones and isoflavones, with particular emphasis on the studies that investigated the cellular and molecular mechanisms involved in the beneficial effects of the compounds.

Authors+Show Affiliations

Division of Nutrition, College of Health, University of Utah, Salt Lake City, UT 84112, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

24029069

Citation

Babu, Pon Velayutham Anandh, et al. "Recent Advances in Understanding the Anti-diabetic Actions of Dietary Flavonoids." The Journal of Nutritional Biochemistry, vol. 24, no. 11, 2013, pp. 1777-89.
Babu PV, Liu D, Gilbert ER. Recent advances in understanding the anti-diabetic actions of dietary flavonoids. J Nutr Biochem. 2013;24(11):1777-89.
Babu, P. V., Liu, D., & Gilbert, E. R. (2013). Recent advances in understanding the anti-diabetic actions of dietary flavonoids. The Journal of Nutritional Biochemistry, 24(11), 1777-89. https://doi.org/10.1016/j.jnutbio.2013.06.003
Babu PV, Liu D, Gilbert ER. Recent Advances in Understanding the Anti-diabetic Actions of Dietary Flavonoids. J Nutr Biochem. 2013;24(11):1777-89. PubMed PMID: 24029069.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Recent advances in understanding the anti-diabetic actions of dietary flavonoids. AU - Babu,Pon Velayutham Anandh, AU - Liu,Dongmin, AU - Gilbert,Elizabeth R, Y1 - 2013/09/09/ PY - 2013/02/05/received PY - 2013/04/02/revised PY - 2013/06/07/accepted PY - 2013/9/14/entrez PY - 2013/9/14/pubmed PY - 2014/5/13/medline KW - ACC KW - AMPK KW - ATP KW - Acetyl Co-A carboxylase KW - Adenosine monophosphate-activated protein kinase KW - Adenosine triphosphate KW - BBE KW - BFE KW - Bayberry fruit extract KW - Bilberry extract KW - Carnitine palmitoyltransferase I KW - DM KW - Diabetes KW - Diabetes mellitus KW - ECG KW - EGC KW - EGCG KW - ER KW - Endoplasmic reticulum KW - Epicatechin gallate KW - Epigallocatechin KW - Epigallocatechin gallate KW - FFA KW - Flavonoids KW - FoXO1 KW - Forkhead box protein O1 KW - Free fatty acid KW - G6Pase KW - GK KW - GLUT KW - GSIS KW - Glucokinase KW - Glucose transporter KW - Glucose-6-phosphatase KW - Glucose-stimulated insulin secretion KW - HSP KW - Heat shock proteins KW - Hyperglycemia KW - IR KW - IRS KW - Insulin receptor KW - Insulin receptor substrate KW - Intraperitoneal KW - Islets KW - JNK KW - L-Cpt-1 KW - MAPK KW - Mitogen activated protein kinase KW - NF-κB KW - NOD KW - Non-obese diabetic mice KW - Nuclear factor-κB KW - PDX-1 KW - PEPCK KW - PGC-1α KW - PKC KW - PPAR KW - Pancreatic duodenal homeobox-1 KW - Pancreatic β-cells KW - Peroxisome proliferator-activated receptor gamma coactivator-1-α KW - Phosphoenolpyruvate carboxykinase KW - Polyphenols KW - Protein kinase C KW - RBP4 KW - RIN cells KW - ROS KW - Rat insulinoma cells KW - Reactive oxygen species KW - Retinol binding protein-4 KW - STZ KW - Streptozotocin KW - T1D KW - T2D KW - TNFα KW - TZD KW - Thiazolidinedione KW - Tumor necrosis factor α KW - Type 1 diabetes mellitus KW - Type 2 diabetes mellitus KW - WAT KW - White adipose tissue KW - c-jun amino terminal kinase KW - cAMP KW - cyclic adenosine mono phosphate KW - i.p. KW - peroxisome proliferator activated receptor SP - 1777 EP - 89 JF - The Journal of nutritional biochemistry JO - J Nutr Biochem VL - 24 IS - 11 N2 - Flavonoids are polyphenolic compounds that are abundant in fruits and vegetables, and increasing evidence demonstrates a positive relationship between consumption of flavonoid-rich foods and disease prevention. Epidemiological, in vitro and animal studies support the beneficial effects of dietary flavonoids on glucose and lipid homeostasis. It is encouraging that the beneficial effects of some flavonoids are at physiological concentrations and comparable to clinically-used anti-diabetic drugs; however, clinical research in this field and studies on the anti-diabetic effects of flavonoid metabolites are limited. Flavonoids act on various molecular targets and regulate different signaling pathways in pancreatic β-cells, hepatocytes, adipocytes and skeletal myofibers. Flavonoids may exert beneficial effects in diabetes by (i) enhancing insulin secretion and reducing apoptosis and promoting proliferation of pancreatic β-cells; (ii) improving hyperglycemia through regulation of glucose metabolism in hepatocytes; (iii) reducing insulin resistance, inflammation and oxidative stress in muscle and fat and (iv) increasing glucose uptake in skeletal muscle and white adipose tissue. This review highlights recent findings on the anti-diabetic effects of dietary flavonoids, including flavan-3-ols, flavanones, flavonols, anthocyanidins, flavones and isoflavones, with particular emphasis on the studies that investigated the cellular and molecular mechanisms involved in the beneficial effects of the compounds. SN - 1873-4847 UR - https://www.unboundmedicine.com/medline/citation/24029069/Recent_advances_in_understanding_the_anti_diabetic_actions_of_dietary_flavonoids_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0955-2863(13)00127-7 DB - PRIME DP - Unbound Medicine ER -