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[The characteristics of high density lipoprotein cholesterol and the relationship between high density lipoprotein cholesterol and the severity of coronary artery lesions in young men with acute myocardial infarction].
Zhonghua Yi Xue Za Zhi. 2013 May 21; 93(19):1458-62.ZY

Abstract

OBJECTIVE

To investigate the characteristics of high density lipoprotein cholesterol and the relationship between high density lipoprotein cholesterol and the severity of coronary artery lesions in young men with acute myocardial infarction (AMI).

METHODS

We retrospectively studied 278 young men with acute myocardial infarction and compared with 208 non-CHD young men, 137 old men with AMI. All patients were admitted to hospital from Jan 2009 to Dec 2011 and undergone coronary angiography, and the clinic and coronary angiographic features were assessed.According to the result of coronary angiography, the patients were divided into three groups:the single, double and triple vessel lesions. The relation between systolic body mass index (BMI), hemoglobin (Hb), serum uric acid (UA), total cholesterol(TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), smoking history, essential hypertension, type 2 diabetes mellitus, familial history of early coronary artery disease with acute myocardial infarction and severity of coronary artery disease are observed.And observe the characteristics of HDL-C in the obesity group and the smoking group in young men based on body mass index and smoking history.

RESULTS

(1) In young men with AMI group, the HDL-C levels was significantly lower than those in non-CHD young men group((1.00 ± 0.28) mmol/L vs (1.05 ± 0.23) mmol/L, P < 0.05).In young men with AMI group, the HDL-C levels was significantly lower than those in old men group with AMI ((1.00 ± 0.28) mmol/L vs (1.07 ± 0.30) mmol/L, P < 0.05);the HDL-C level in young AMI men with smoking history was significantly lower than those in young AMI men without smoking history ((0.98 ± 0.25) mmol/L vs (1.09 ± 0.40) mmol/L, P < 0.05);the HDL-C level in normal weight group is significantly higher than those in overweight and obesity groups in young AMI men ((1.30 ± 0.55) mmol/L vs (0.99 ± 0.22) mmol/L, (0.98 ± 0.29) mmol/L, P < 0.05). (2)The HDL-C level in the single lesions group was significantly lower than those in the double and triple vessel lesions groups ((1.06 ± 0.29) mmol/L vs (0.92 ± 0.20) mmol/L, (0.91 ± 0.26) mmol/L, P < 0.05). (3) Applying Logistic regression analysis, type 2 diabetes mellitus (OR = 35.784), essential hypertension (OR = 7.782), familial history of early coronary artery disease (OR = 4.613), low density lipoprotein cholesterol (OR = 2.496), smoking history (OR = 2.241), hemoglobin (OR = 1.042) and serum uric acid (OR = 1.005) are independent risk factors (P < 0.05) for young men with AMI, while high density lipoprotein cholesterol (OR = 0.147, P < 0.05) is a protective factor; low density lipoprotein cholesterol (OR = 2.095) and essential hypertension (OR = 1.042) are independent risk factors (P < 0.05) for young men with multiple vessel lesions in AMI, while high density lipoprotein cholesterol (OR = 0.071, P < 0.05) is a protective factor.

CONCLUSION

High density lipoprotein cholesterol are protective factors for young men with AMI and multiple vessel lesions in young men with AMI.

Authors+Show Affiliations

Department of Cardiology, BeijCapital University of Medical Sciences, Beijing, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

24029567

Citation

Li, Zhao, et al. "[The Characteristics of High Density Lipoprotein Cholesterol and the Relationship Between High Density Lipoprotein Cholesterol and the Severity of Coronary Artery Lesions in Young Men With Acute Myocardial Infarction]." Zhonghua Yi Xue Za Zhi, vol. 93, no. 19, 2013, pp. 1458-62.
Li Z, Tao Y, Huang J, et al. [The characteristics of high density lipoprotein cholesterol and the relationship between high density lipoprotein cholesterol and the severity of coronary artery lesions in young men with acute myocardial infarction]. Zhonghua Yi Xue Za Zhi. 2013;93(19):1458-62.
Li, Z., Tao, Y., Huang, J., Wang, Q., Zhang, D. H., & Wu, X. Y. (2013). [The characteristics of high density lipoprotein cholesterol and the relationship between high density lipoprotein cholesterol and the severity of coronary artery lesions in young men with acute myocardial infarction]. Zhonghua Yi Xue Za Zhi, 93(19), 1458-62.
Li Z, et al. [The Characteristics of High Density Lipoprotein Cholesterol and the Relationship Between High Density Lipoprotein Cholesterol and the Severity of Coronary Artery Lesions in Young Men With Acute Myocardial Infarction]. Zhonghua Yi Xue Za Zhi. 2013 May 21;93(19):1458-62. PubMed PMID: 24029567.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [The characteristics of high density lipoprotein cholesterol and the relationship between high density lipoprotein cholesterol and the severity of coronary artery lesions in young men with acute myocardial infarction]. AU - Li,Zhao, AU - Tao,Ying, AU - Huang,Ji, AU - Wang,Qian, AU - Zhang,Dong-hua, AU - Wu,Xiang-yu, PY - 2013/9/14/entrez PY - 2013/9/14/pubmed PY - 2014/3/13/medline SP - 1458 EP - 62 JF - Zhonghua yi xue za zhi JO - Zhonghua Yi Xue Za Zhi VL - 93 IS - 19 N2 - OBJECTIVE: To investigate the characteristics of high density lipoprotein cholesterol and the relationship between high density lipoprotein cholesterol and the severity of coronary artery lesions in young men with acute myocardial infarction (AMI). METHODS: We retrospectively studied 278 young men with acute myocardial infarction and compared with 208 non-CHD young men, 137 old men with AMI. All patients were admitted to hospital from Jan 2009 to Dec 2011 and undergone coronary angiography, and the clinic and coronary angiographic features were assessed.According to the result of coronary angiography, the patients were divided into three groups:the single, double and triple vessel lesions. The relation between systolic body mass index (BMI), hemoglobin (Hb), serum uric acid (UA), total cholesterol(TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), smoking history, essential hypertension, type 2 diabetes mellitus, familial history of early coronary artery disease with acute myocardial infarction and severity of coronary artery disease are observed.And observe the characteristics of HDL-C in the obesity group and the smoking group in young men based on body mass index and smoking history. RESULTS: (1) In young men with AMI group, the HDL-C levels was significantly lower than those in non-CHD young men group((1.00 ± 0.28) mmol/L vs (1.05 ± 0.23) mmol/L, P < 0.05).In young men with AMI group, the HDL-C levels was significantly lower than those in old men group with AMI ((1.00 ± 0.28) mmol/L vs (1.07 ± 0.30) mmol/L, P < 0.05);the HDL-C level in young AMI men with smoking history was significantly lower than those in young AMI men without smoking history ((0.98 ± 0.25) mmol/L vs (1.09 ± 0.40) mmol/L, P < 0.05);the HDL-C level in normal weight group is significantly higher than those in overweight and obesity groups in young AMI men ((1.30 ± 0.55) mmol/L vs (0.99 ± 0.22) mmol/L, (0.98 ± 0.29) mmol/L, P < 0.05). (2)The HDL-C level in the single lesions group was significantly lower than those in the double and triple vessel lesions groups ((1.06 ± 0.29) mmol/L vs (0.92 ± 0.20) mmol/L, (0.91 ± 0.26) mmol/L, P < 0.05). (3) Applying Logistic regression analysis, type 2 diabetes mellitus (OR = 35.784), essential hypertension (OR = 7.782), familial history of early coronary artery disease (OR = 4.613), low density lipoprotein cholesterol (OR = 2.496), smoking history (OR = 2.241), hemoglobin (OR = 1.042) and serum uric acid (OR = 1.005) are independent risk factors (P < 0.05) for young men with AMI, while high density lipoprotein cholesterol (OR = 0.147, P < 0.05) is a protective factor; low density lipoprotein cholesterol (OR = 2.095) and essential hypertension (OR = 1.042) are independent risk factors (P < 0.05) for young men with multiple vessel lesions in AMI, while high density lipoprotein cholesterol (OR = 0.071, P < 0.05) is a protective factor. CONCLUSION: High density lipoprotein cholesterol are protective factors for young men with AMI and multiple vessel lesions in young men with AMI. SN - 0376-2491 UR - https://www.unboundmedicine.com/medline/citation/24029567/[The_characteristics_of_high_density_lipoprotein_cholesterol_and_the_relationship_between_high_density_lipoprotein_cholesterol_and_the_severity_of_coronary_artery_lesions_in_young_men_with_acute_myocardial_infarction]_ L2 - http://journal.yiigle.com/LinkIn.do?linkin_type=pubmed&amp;issn=0376-2491&amp;year=2013&amp;vol=93&amp;issue=19&amp;fpage=1458 DB - PRIME DP - Unbound Medicine ER -