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A narrow-band ultraviolet B course improves vitamin D balance and alters cutaneous CYP27A1 and CYP27B1 mRNA expression levels in haemodialysis patients supplemented with oral vitamin D.
Nephron Clin Pract. 2013; 124(1-2):17-22.NC

Abstract

BACKGROUND/AIMS

Chronic kidney disease (CKD) patients on dialysis are prone to vitamin D insufficiency despite oral vitamin D supplementation. Here, we studied whether narrow-band ultraviolet B (NB-UVB) exposures improve vitamin D balance.

METHODS

14 haemodialysis patients and 15 healthy subjects receiving oral cholecalciferol 20 µg daily got nine NB-UVB exposures on the entire body. Serum 25-hydroxyvitamin D (25(OH)D) was measured by radioimmunoassay. Cutaneous mRNA expression levels of CYP27A1 and CYP27B1, two enzymes required for hydroxylation of vitamin D into its active metabolite, were also measured.

RESULTS

The baseline serum 25(OH)D concentration was 57.6 ± 18.2 nmol/l in the CKD patients and 74.3 ± 14.8 nmol/l in the healthy subjects. The NB-UVB course increased serum 25(OH)D by 14.0 nmol/l (95% CI 8.7-19.5) and 17.0 nmol/l (CI 13.7-20.2), respectively. At baseline the CKD patients showed significantly increased CYP27B1 levels compared to the healthy subjects.

CONCLUSIONS

A short NB-UVB course is an efficient way to improve vitamin D balance in CKD patients on dialysis who are receiving oral vitamin D supplementation. The increased cutaneous CYP27B1 levels in the CKD patients suggest that the loss of renal activity of this enzyme is at least partially compensated for by the skin.

Authors+Show Affiliations

Department of Dermatology, Tampere University Hospital, Tampere, Finland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Controlled Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24029861

Citation

Ala-Houhala, Meri J., et al. "A Narrow-band Ultraviolet B Course Improves Vitamin D Balance and Alters Cutaneous CYP27A1 and CYP27B1 mRNA Expression Levels in Haemodialysis Patients Supplemented With Oral Vitamin D." Nephron. Clinical Practice, vol. 124, no. 1-2, 2013, pp. 17-22.
Ala-Houhala MJ, Vähävihu K, Snellman E, et al. A narrow-band ultraviolet B course improves vitamin D balance and alters cutaneous CYP27A1 and CYP27B1 mRNA expression levels in haemodialysis patients supplemented with oral vitamin D. Nephron Clin Pract. 2013;124(1-2):17-22.
Ala-Houhala, M. J., Vähävihu, K., Snellman, E., Hasan, T., Kautiainen, H., Karisola, P., Dombrowski, Y., Schauber, J., Saha, H., & Reunala, T. (2013). A narrow-band ultraviolet B course improves vitamin D balance and alters cutaneous CYP27A1 and CYP27B1 mRNA expression levels in haemodialysis patients supplemented with oral vitamin D. Nephron. Clinical Practice, 124(1-2), 17-22. https://doi.org/10.1159/000355010
Ala-Houhala MJ, et al. A Narrow-band Ultraviolet B Course Improves Vitamin D Balance and Alters Cutaneous CYP27A1 and CYP27B1 mRNA Expression Levels in Haemodialysis Patients Supplemented With Oral Vitamin D. Nephron Clin Pract. 2013;124(1-2):17-22. PubMed PMID: 24029861.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A narrow-band ultraviolet B course improves vitamin D balance and alters cutaneous CYP27A1 and CYP27B1 mRNA expression levels in haemodialysis patients supplemented with oral vitamin D. AU - Ala-Houhala,Meri J, AU - Vähävihu,Katja, AU - Snellman,Erna, AU - Hasan,Taina, AU - Kautiainen,Hannu, AU - Karisola,Piia, AU - Dombrowski,Yvonne, AU - Schauber,Jürgen, AU - Saha,Heikki, AU - Reunala,Timo, Y1 - 2013/09/12/ PY - 2013/03/18/received PY - 2013/08/10/accepted PY - 2013/9/14/entrez PY - 2013/9/14/pubmed PY - 2014/8/13/medline SP - 17 EP - 22 JF - Nephron. Clinical practice JO - Nephron Clin Pract VL - 124 IS - 1-2 N2 - BACKGROUND/AIMS: Chronic kidney disease (CKD) patients on dialysis are prone to vitamin D insufficiency despite oral vitamin D supplementation. Here, we studied whether narrow-band ultraviolet B (NB-UVB) exposures improve vitamin D balance. METHODS: 14 haemodialysis patients and 15 healthy subjects receiving oral cholecalciferol 20 µg daily got nine NB-UVB exposures on the entire body. Serum 25-hydroxyvitamin D (25(OH)D) was measured by radioimmunoassay. Cutaneous mRNA expression levels of CYP27A1 and CYP27B1, two enzymes required for hydroxylation of vitamin D into its active metabolite, were also measured. RESULTS: The baseline serum 25(OH)D concentration was 57.6 ± 18.2 nmol/l in the CKD patients and 74.3 ± 14.8 nmol/l in the healthy subjects. The NB-UVB course increased serum 25(OH)D by 14.0 nmol/l (95% CI 8.7-19.5) and 17.0 nmol/l (CI 13.7-20.2), respectively. At baseline the CKD patients showed significantly increased CYP27B1 levels compared to the healthy subjects. CONCLUSIONS: A short NB-UVB course is an efficient way to improve vitamin D balance in CKD patients on dialysis who are receiving oral vitamin D supplementation. The increased cutaneous CYP27B1 levels in the CKD patients suggest that the loss of renal activity of this enzyme is at least partially compensated for by the skin. SN - 1660-2110 UR - https://www.unboundmedicine.com/medline/citation/24029861/A_narrow_band_ultraviolet_B_course_improves_vitamin_D_balance_and_alters_cutaneous_CYP27A1_and_CYP27B1_mRNA_expression_levels_in_haemodialysis_patients_supplemented_with_oral_vitamin_D_ L2 - https://www.karger.com?DOI=10.1159/000355010 DB - PRIME DP - Unbound Medicine ER -