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Do data in the literature indicate that glycaemic variability is a clinical problem? Glycaemic variability and vascular complications of diabetes.
Diabetes Obes Metab. 2013 Sep; 15 Suppl 2:3-8.DO

Abstract

In recent years glycaemic variability (GV) has emerged as a determinant of vascular complications of both type 1 and type 2 diabetes mellitus. In type 1 diabetes analysis of data of GV show conflicting results on both micro- and macro-vascular complications. In non-diabetic subjects blood glucose after loading is a stronger predictor of cardiovascular complications than fasting glucose. In type 2 diabetes both coefficient of variation of fasting blood glucose and postprandial blood glucose predict cardiovascular events. Also, long term variability of HbA1c has been associated predominantly with diabetic nephropathy, less frequently with retinopathy. Intervention trials to evaluate the effect of postprandial glucose have been conducted only in prediabetes or in type 2 diabetes and the data are not conclusive. In vitro and in vivo data have shown the mechanisms that are at the basis of the adverse cardiovascular effects of GV, mainly associated with oxidative stress; the atherogenic action of postprandial glucose also involves insulin sensitivity, postprandial increase in serum lipids and glycaemic index of food. Thus, correction of GV emerges as a target to be pursued in clinical practice in order to safely reduce mean blood glucose (and thus glycated haemoglobin) and for its direct effects on vascular complications of diabetes.

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Authors+Show Affiliations

Cavalot F
Internal Medicine and Metabolic Diseases Unit, San Luigi Gonzaga University Hospital, Turin, Italy.

MeSH

Analysis of VarianceBlood GlucoseCardiovascular DiseasesDiabetes Mellitus, Type 1Diabetes Mellitus, Type 2Diabetic AngiopathiesFastingFemaleGlycated Hemoglobin AHumansHyperglycemiaHypoglycemiaHypoglycemic AgentsMaleMonitoring, PhysiologicPostprandial PeriodRisk Factors

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

24034513

Citation

Cavalot, F. "Do Data in the Literature Indicate That Glycaemic Variability Is a Clinical Problem? Glycaemic Variability and Vascular Complications of Diabetes." Diabetes, Obesity & Metabolism, vol. 15 Suppl 2, 2013, pp. 3-8.
Cavalot F. Do data in the literature indicate that glycaemic variability is a clinical problem? Glycaemic variability and vascular complications of diabetes. Diabetes Obes Metab. 2013;15 Suppl 2:3-8.
Cavalot, F. (2013). Do data in the literature indicate that glycaemic variability is a clinical problem? Glycaemic variability and vascular complications of diabetes. Diabetes, Obesity & Metabolism, 15 Suppl 2, 3-8. https://doi.org/10.1111/dom.12140
Cavalot F. Do Data in the Literature Indicate That Glycaemic Variability Is a Clinical Problem? Glycaemic Variability and Vascular Complications of Diabetes. Diabetes Obes Metab. 2013;15 Suppl 2:3-8. PubMed PMID: 24034513.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Do data in the literature indicate that glycaemic variability is a clinical problem? Glycaemic variability and vascular complications of diabetes. A1 - Cavalot,F, PY - 2013/04/23/received PY - 2013/04/25/accepted PY - 2013/9/17/entrez PY - 2013/9/27/pubmed PY - 2014/4/16/medline KW - fasting blood glucose KW - glycaemic variability KW - glycated haemoglobin KW - postprandial blood glucose KW - type 1 diabetes KW - type 2 diabetes KW - vascular complications SP - 3 EP - 8 JF - Diabetes, obesity & metabolism JO - Diabetes Obes Metab VL - 15 Suppl 2 N2 - In recent years glycaemic variability (GV) has emerged as a determinant of vascular complications of both type 1 and type 2 diabetes mellitus. In type 1 diabetes analysis of data of GV show conflicting results on both micro- and macro-vascular complications. In non-diabetic subjects blood glucose after loading is a stronger predictor of cardiovascular complications than fasting glucose. In type 2 diabetes both coefficient of variation of fasting blood glucose and postprandial blood glucose predict cardiovascular events. Also, long term variability of HbA1c has been associated predominantly with diabetic nephropathy, less frequently with retinopathy. Intervention trials to evaluate the effect of postprandial glucose have been conducted only in prediabetes or in type 2 diabetes and the data are not conclusive. In vitro and in vivo data have shown the mechanisms that are at the basis of the adverse cardiovascular effects of GV, mainly associated with oxidative stress; the atherogenic action of postprandial glucose also involves insulin sensitivity, postprandial increase in serum lipids and glycaemic index of food. Thus, correction of GV emerges as a target to be pursued in clinical practice in order to safely reduce mean blood glucose (and thus glycated haemoglobin) and for its direct effects on vascular complications of diabetes. SN - 1463-1326 UR - https://www.unboundmedicine.com/medline/citation/24034513/Do_data_in_the_literature_indicate_that_glycaemic_variability_is_a_clinical_problem_Glycaemic_variability_and_vascular_complications_of_diabetes_ L2 - https://doi.org/10.1111/dom.12140 DB - PRIME DP - Unbound Medicine ER -