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Higher glycemic index and glycemic load diet is associated with increased risk of esophageal squamous cell carcinoma: a case-control study.
Nutr Res. 2013 Sep; 33(9):719-25.NR

Abstract

Several studies have indicated the association between intake of foods high in dietary glycemic index (GI) and glycemic load (GL) with an increased risk of digestive tract cancers. We hypothesized that GI and GL may be associated with risk of esophageal squamous cell carcinoma (ESCC) in a high-risk population in Iran. In total, we interviewed 47 cases with incident of ESCC and 96 frequency-matched hospital controls, then calculated the average dietary GI and GL via a validated food frequency questionnaire. Dietary GL was calculated as a function of GI, carbohydrate content, and frequency of intake of certain foods. Dietary GI and GL levels were significantly higher among the ESCC cases compared with the controls (P < .05). After adjustment for potential confounders, those in the highest tertile of dietary GI had 2.95 times higher risk of ESCC compared with those in the lowest (95% confidence interval, 1.68-3.35; P for trend = .002). In addition, being in the highest tertile of dietary GL was positively associated with an ESCC risk (odds ratio, 3.49; 95% confidence interval, 2.98-4.41; P for trend = .001). Findings of the present study indicate that diets with high GI and GL might have potentially unfavorable effects on ESCC risk and suggest a possible role for excess circulating insulin and related insulin-like growth factor 1 in esophageal cancer development.

Authors+Show Affiliations

Students' Research Committee, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute (WHO Collaborating Center), Shahid Beheshti University of Medical Sciences, Tehran, Iran.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24034571

Citation

Eslamian, Ghazaleh, et al. "Higher Glycemic Index and Glycemic Load Diet Is Associated With Increased Risk of Esophageal Squamous Cell Carcinoma: a Case-control Study." Nutrition Research (New York, N.Y.), vol. 33, no. 9, 2013, pp. 719-25.
Eslamian G, Jessri M, Hajizadeh B, et al. Higher glycemic index and glycemic load diet is associated with increased risk of esophageal squamous cell carcinoma: a case-control study. Nutr Res. 2013;33(9):719-25.
Eslamian, G., Jessri, M., Hajizadeh, B., Ibiebele, T. I., & Rashidkhani, B. (2013). Higher glycemic index and glycemic load diet is associated with increased risk of esophageal squamous cell carcinoma: a case-control study. Nutrition Research (New York, N.Y.), 33(9), 719-25. https://doi.org/10.1016/j.nutres.2013.06.002
Eslamian G, et al. Higher Glycemic Index and Glycemic Load Diet Is Associated With Increased Risk of Esophageal Squamous Cell Carcinoma: a Case-control Study. Nutr Res. 2013;33(9):719-25. PubMed PMID: 24034571.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Higher glycemic index and glycemic load diet is associated with increased risk of esophageal squamous cell carcinoma: a case-control study. AU - Eslamian,Ghazaleh, AU - Jessri,Mahsa, AU - Hajizadeh,Bahareh, AU - Ibiebele,Torukiri I, AU - Rashidkhani,Bahram, Y1 - 2013/07/23/ PY - 2012/07/10/received PY - 2013/05/30/revised PY - 2013/06/14/accepted PY - 2013/9/17/entrez PY - 2013/9/17/pubmed PY - 2014/4/22/medline KW - BMI KW - CIs KW - Carbohydrate KW - Case control KW - EC KW - ESCC KW - Esophageal squamous cell carcinoma KW - FCT KW - FFQ KW - Fiber KW - GERD KW - GI KW - GL KW - Glycemic index KW - Glycemic load KW - IGF-1 KW - ORs KW - US Department of Agriculture KW - USDA KW - body mass index KW - confidence intervals KW - esophageal cancer KW - esophageal squamous cell carcinoma KW - food composition table KW - food frequency questionnaire KW - gastroesophageal reflux disease KW - glycemic index KW - glycemic load KW - insulin-like growth factor 1 KW - odds ratios SP - 719 EP - 25 JF - Nutrition research (New York, N.Y.) JO - Nutr Res VL - 33 IS - 9 N2 - Several studies have indicated the association between intake of foods high in dietary glycemic index (GI) and glycemic load (GL) with an increased risk of digestive tract cancers. We hypothesized that GI and GL may be associated with risk of esophageal squamous cell carcinoma (ESCC) in a high-risk population in Iran. In total, we interviewed 47 cases with incident of ESCC and 96 frequency-matched hospital controls, then calculated the average dietary GI and GL via a validated food frequency questionnaire. Dietary GL was calculated as a function of GI, carbohydrate content, and frequency of intake of certain foods. Dietary GI and GL levels were significantly higher among the ESCC cases compared with the controls (P < .05). After adjustment for potential confounders, those in the highest tertile of dietary GI had 2.95 times higher risk of ESCC compared with those in the lowest (95% confidence interval, 1.68-3.35; P for trend = .002). In addition, being in the highest tertile of dietary GL was positively associated with an ESCC risk (odds ratio, 3.49; 95% confidence interval, 2.98-4.41; P for trend = .001). Findings of the present study indicate that diets with high GI and GL might have potentially unfavorable effects on ESCC risk and suggest a possible role for excess circulating insulin and related insulin-like growth factor 1 in esophageal cancer development. SN - 1879-0739 UR - https://www.unboundmedicine.com/medline/citation/24034571/Higher_glycemic_index_and_glycemic_load_diet_is_associated_with_increased_risk_of_esophageal_squamous_cell_carcinoma:_a_case_control_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0271-5317(13)00146-2 DB - PRIME DP - Unbound Medicine ER -