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Effect of calcium or vitamin D supplementation on vascular outcomes: a meta-analysis of randomized controlled trials.
Int J Cardiol 2013; 169(2):106-11IJ

Abstract

BACKGROUND

Whether calcium or vitamin D supplementation reduces serious vascular outcomes in older people remains unclear. We conducted a meta-analysis based on randomized controlled trials to evaluate the effect of calcium or vitamin D supplementation on the risk of major cardiovascular outcomes.

METHODS

We performed electronic searches in PubMed, Embase, and the Cochrane Library to identify relevant randomized controlled trials. Odds ratios (ORs) were used to measure the effect of calcium or vitamin D supplementation on the risk of major vascular outcomes with a random-effect model.

RESULTS

Of the 1643 identified studies, we included 11 trials reporting data on 50,252 individuals. These studies reported 2685 major cardiovascular events, 1097 events of myocardial infarction, and 1350 events of stroke. Calcium or vitamin D supplementation did not have an effect on major cardiovascular events (OR, 1.03; 95% confidence interval [CI]: 0.94-1.12; P=0.54), myocardial infarction (OR, 1.08; 95% CI: 0.96-1.22; P=0.21), or stroke (OR, 1.01; 95% CI: 0.91-1.13; P=0.80) when compared to the effect with a placebo. Subgroup analysis indicated that calcium supplementation alone might play an important role in increasing the risk of major cardiovascular events, myocardial infarction, and stroke, but this difference could not be identified as statistically significant. Furthermore, males seem to experience more harmful effects with supplements of calcium or vitamin D than the effects experienced by females.

CONCLUSIONS

Calcium supplementation might increase the risk of major cardiovascular events, myocardial infarction, and stroke compared to the risk with a placebo.

Authors+Show Affiliations

Department of VIP Special Clinic, Shanghai Seventh People's Hospital, Shanghai, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24035175

Citation

Mao, Pei-Juan, et al. "Effect of Calcium or Vitamin D Supplementation On Vascular Outcomes: a Meta-analysis of Randomized Controlled Trials." International Journal of Cardiology, vol. 169, no. 2, 2013, pp. 106-11.
Mao PJ, Zhang C, Tang L, et al. Effect of calcium or vitamin D supplementation on vascular outcomes: a meta-analysis of randomized controlled trials. Int J Cardiol. 2013;169(2):106-11.
Mao, P. J., Zhang, C., Tang, L., Xian, Y. Q., Li, Y. S., Wang, W. D., ... Zhou, Y. H. (2013). Effect of calcium or vitamin D supplementation on vascular outcomes: a meta-analysis of randomized controlled trials. International Journal of Cardiology, 169(2), pp. 106-11. doi:10.1016/j.ijcard.2013.08.055.
Mao PJ, et al. Effect of Calcium or Vitamin D Supplementation On Vascular Outcomes: a Meta-analysis of Randomized Controlled Trials. Int J Cardiol. 2013 Oct 30;169(2):106-11. PubMed PMID: 24035175.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of calcium or vitamin D supplementation on vascular outcomes: a meta-analysis of randomized controlled trials. AU - Mao,Pei-Juan, AU - Zhang,Chi, AU - Tang,Lan, AU - Xian,Yu-Qiong, AU - Li,Yan-Song, AU - Wang,Wei-Dong, AU - Zhu,Xiu-Hua, AU - Qiu,Hua-Li, AU - He,Jia, AU - Zhou,Yu-Hao, Y1 - 2013/08/27/ PY - 2013/05/31/received PY - 2013/08/07/revised PY - 2013/08/18/accepted PY - 2013/9/17/entrez PY - 2013/9/17/pubmed PY - 2014/7/9/medline KW - Calcium KW - Meta-analysis KW - Myocardial infarction KW - Stroke KW - Vitamin D SP - 106 EP - 11 JF - International journal of cardiology JO - Int. J. Cardiol. VL - 169 IS - 2 N2 - BACKGROUND: Whether calcium or vitamin D supplementation reduces serious vascular outcomes in older people remains unclear. We conducted a meta-analysis based on randomized controlled trials to evaluate the effect of calcium or vitamin D supplementation on the risk of major cardiovascular outcomes. METHODS: We performed electronic searches in PubMed, Embase, and the Cochrane Library to identify relevant randomized controlled trials. Odds ratios (ORs) were used to measure the effect of calcium or vitamin D supplementation on the risk of major vascular outcomes with a random-effect model. RESULTS: Of the 1643 identified studies, we included 11 trials reporting data on 50,252 individuals. These studies reported 2685 major cardiovascular events, 1097 events of myocardial infarction, and 1350 events of stroke. Calcium or vitamin D supplementation did not have an effect on major cardiovascular events (OR, 1.03; 95% confidence interval [CI]: 0.94-1.12; P=0.54), myocardial infarction (OR, 1.08; 95% CI: 0.96-1.22; P=0.21), or stroke (OR, 1.01; 95% CI: 0.91-1.13; P=0.80) when compared to the effect with a placebo. Subgroup analysis indicated that calcium supplementation alone might play an important role in increasing the risk of major cardiovascular events, myocardial infarction, and stroke, but this difference could not be identified as statistically significant. Furthermore, males seem to experience more harmful effects with supplements of calcium or vitamin D than the effects experienced by females. CONCLUSIONS: Calcium supplementation might increase the risk of major cardiovascular events, myocardial infarction, and stroke compared to the risk with a placebo. SN - 1874-1754 UR - https://www.unboundmedicine.com/medline/citation/24035175/Effect_of_calcium_or_vitamin_D_supplementation_on_vascular_outcomes:_a_meta_analysis_of_randomized_controlled_trials_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0167-5273(13)01617-3 DB - PRIME DP - Unbound Medicine ER -